Abstract
Theranostic nanosystem has been demonstrated great potential in real-timely monitoring drug biodistribution and therapeutic response. It is still a challenge to fabricate a theranostic nanosystem that possesses the properties of good biocompatibility, a high magnetic resonance imaging (MRI) sensitivity, and stimuli-responsive drug release for the diagnosis and treatment of hepatocellular carcinoma. Here, a pH-responsive micelle, which was self-assembled from biodegradable poly(amino acid) block copolymer mPEG-PAsp(DIP)-co-PLLeu, was constructed to load both chemotherapeutic paclitaxel (PTX) and MRI contrast agent superparamagnetic iron oxide nanoparticles (SPIONs). The SPIONs/PTX-coloaded PDPL micelle (SPIONs/PTX-PDPL) had a hydrodynamic particle size of 134.5 ± 11.2 nm. The theranostic SPIONs/PTX-PDPL not only effectively delivered PTX and SPION into Bel-7402 cancer cells but also rapidly released PTX in acidic lysosome to induce cell apoptosis. Meanwhile, in vitro MR imaging sensitively detected the liver cancer cells after co-incubation with SPIONs/PTX-PDPL micelle. The SPIONs/PTX-PDPL micelle is a potential theranostic nanosystem in terms of the simultaneous chemotherapy and MR imaging of hepatocellular carcinoma.
A novel pH-responsive polymeric micelle was synthesized to co-deliver chemotherapy drug paclitaxel (PTX) and MRI contrast agent superparamagnetic iron oxide nanoparticles (SPIONs) for simultaneous chemotherapy and MR imaging of hepatocellular carcinoma.
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11 November 2023
A Correction to this paper has been published: https://doi.org/10.1007/s11051-023-05871-7
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Funding
This work was supported by the National Natural Science Foundation of China (81701812, 21905112), the Research Foundation of Zhejiang Chinese Medical University (2018ZR05), and the Science and Technology Foundation of Wenzhou City (Y20140725).
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Xiao, H., Li, X., Zheng, C. et al. Intracellular pH-responsive polymeric micelle for simultaneous chemotherapy and MR imaging of hepatocellular carcinoma. J Nanopart Res 22, 105 (2020). https://doi.org/10.1007/s11051-020-04821-x
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DOI: https://doi.org/10.1007/s11051-020-04821-x