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Influence of the synthesis conditions of gold nanoparticles on the structure and architectonics of dipeptide composites

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Abstract

A wide variety of peptides and their natural ability to self-assemble makes them very promising candidates for the fabrication of solid-state devices based on nano- and mesocrystals. In this work, we demonstrate an approach to form peptide composite layers with gold nanoparticles through in situ reduction of chloroauric acid trihydrate by dipeptide and/or dipeptide/formaldehyde mixture in the presence of potassium carbonate at different ratios of components. Appropriate composition of components for the synthesis of highly stable gold colloidal dispersion with particle size of 34–36 nm in dipeptide/formaldehyde solution is formulated. Infrared spectroscopy results indicate that dipeptide participates in the reduction process, conjugation with gold nanoparticles and the self-assembly in 2D, which accompanied by changing peptide chain conformations. The structure and morphology of the peptide composite solid layers with gold nanoparticles on gold, mica and silica surfaces are characterized by atomic force microscopy. In these experiments, the flat particles, dendrites, chains, mesocrystals and Janus particles are observed depending on the solution composition and the substrate/interface used. The latter aspect is studied on the molecular level using computer simulations of individual peptide chains on gold, mica and silica surfaces.

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Acknowledgments

This study was supported by the Ministry of Education and Science of the Russian Federation and by financial support from Russian Foundation for Basic Research, contract No. 15-07-01733.

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Authors and Affiliations

  1. Moscow State Technological University STANKIN, Vadkovskii per. 1, Moscow, Russia, 127994

    Alexander I. Loskutov, Sergey N. Grigoriev & Vadim B. Oshurko

  2. Leibniz Institute of Polymer Research Dresden, Hohe Str. 6, 01069, Dresden, Germany

    Olga A. Guskova

  3. Dresden Center for Computational Materials Science (DCMS), Technische Universität Dresden, 01062, Dresden, Germany

    Olga A. Guskova

  4. FSBI “Zakusov Institute of Pharmacology”, Russian Academy of Medical Sciences, Baltiyskaya str. 8, Moscow, Russia, 125315

    Aleksei V. Tarasiuk

  5. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Leninskii pr. 31, Moscow, Russia, 119991

    Olga Ya. Uryupina

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  1. Alexander I. Loskutov
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  2. Olga A. Guskova
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  3. Sergey N. Grigoriev
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  4. Vadim B. Oshurko
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Correspondence to Alexander I. Loskutov.

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Loskutov, A.I., Guskova, O.A., Grigoriev, S.N. et al. Influence of the synthesis conditions of gold nanoparticles on the structure and architectonics of dipeptide composites. J Nanopart Res 18, 239 (2016). https://doi.org/10.1007/s11051-016-3548-1

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