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Isolated Cutaneous Granuloma Caused by Candida glabrata: A Rare Case Report and Literature Review

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Abstract

The incidence of candidiasis due to non-albicans Candida species (especially Candida glabrata) has significantly increased in recent decades. Candida glabrata often invades immunocompromised hosts and causes systemic or mucosal infections, whereas cutaneous infections are rarely reported. We present a rare case of cutaneous infection caused by C. glabrata and review all similar cases available in the PubMed database. A patient was admitted to the hospital with a 2-month history of a plaque on the face. Histopathological examination displayed typical infectious granulomas in the deep dermis, and the pathogen was finally confirmed as C. glabrata using a series of microbial examinations (fungal culture, biochemical test, and PCR-directed sequencing). The patient was completely cured after 4 months of treatment with oral itraconazole combined with topical terbinafine. We reviewed similar reports of cutaneous infection caused by C. glabrata. All the data suggested that an accurate diagnosis of cutaneous candidiasis depends mainly on histological and fungal examinations, especially molecular biological assays. Antifungal agents based on microbial susceptibility tests are the first-line treatment choice for C. glabrata infection, but the prognosis might be more dependent on the basic condition of the host.

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Abbreviations

PCR:

Polymerase chain reaction

AIDS:

Acquired immune deficiency syndrome

SDA:

Sabouraud agar

H&E:

Hematoxylin and eosin

MIC:

Minimal inhibitory concentration

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Acknowledgements

We thank Dr. Huyan Chen at the Department of Dermatology (Huashan Hospital, Fudan University) for the histopathological instruction.

Funding

This study was supported by the Natural Science Foundation of Zhejiang Province (LQ14H190002) and China Postdoctoral Science Foundation Grant (2016M600286).

Authors’ Contributions

YF, WP, GW, YH, YL, WF, and XT contributed substantially to the conception of the study and analysis and interpretation of the data. All authors read and approved the final manuscript.

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Author notes

  1. Yibin Fan and Weili Pan have contributed equally to this work.

Authors and Affiliations

  1. Department of Dermatology, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, No. 158, Shangtang Road, Hangzhou, 310014, Zhejiang, China

    Yibin Fan, Weili Pan, Youming Huang, Yali Li & Xiaohua Tao

  2. Emergency Room, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, China

    Guizhen Wang

  3. Department of Dermatology, Huashan Hospital, Fudan University, No. 12, Middle Urumqi Road, Shanghai, 200040, China

    Wei Fang

  4. Shanghai Key Laboratory of Molecular Medical Mycology, Department of Dermatology and Venereology, Changzheng Hospital, Shanghai, China

    Wei Fang

Authors
  1. Yibin Fan
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  2. Weili Pan
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  3. Guizhen Wang
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  4. Youming Huang
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  5. Yali Li
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  6. Wei Fang
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  7. Xiaohua Tao
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Corresponding authors

Correspondence to Wei Fang or Xiaohua Tao.

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Conflict of interests

The authors have no conflicts of interest to report.

Ethics Approval

This study was proved by the Committee on Ethics of Biomedicine Research, Zhejiang Provincial People’s Hospital.

Informed Consent

Informed written consent was obtained from the patient prior to publication of the case details.

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Fan, Y., Pan, W., Wang, G. et al. Isolated Cutaneous Granuloma Caused by Candida glabrata: A Rare Case Report and Literature Review. Mycopathologia 183, 417–421 (2018). https://doi.org/10.1007/s11046-017-0228-3

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  • DOI: https://doi.org/10.1007/s11046-017-0228-3

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