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Candida dubliniensis Pneumonia: A Case Report and Review of Literature

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Abstract

Candida dubliniensis is an uncommon species of Candida which has been implicated in fungal pneumonia only very rarely. We present the case of a 75-year-old man with laryngeal cancer undergoing chemotherapy on broad-spectrum antibiotics and tuberculosis therapy with blood and endotracheal cultures positive for C. dubliniensis. Subsequent autopsy was performed with postmortem lung cultures positive for C. dubliniensis and lung histopathology demonstrating an invasive fungal infection. Molecular analysis of the lung tissue confirmed the identity of the fungi as C. dubliniensis. Since its discovery as a pathogen in the oral cavities of HIV-positive patients, C. dubliniensis has been identified in a wide spectrum of clinical scenarios and anatomic locations but manifests only rarely as pneumonia. This report represents a novel case of C. dubliniensis pneumonia confirmed by culture, histopathology, and molecular identification.

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References

  1. Khan Z, Ahmad S, Joseph L, Chandy R. Candida dubliniensis: an appraisal of its clinical significance as a bloodstream pathogen. PLoS ONE. 2012;7(3):e32952. doi:10.1371/journal.pone.0032952.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Lai CC, Tsai HY, Chang TC, Hsueh PR. Catheter-related fungemia caused by Candida dubliniensis. J Microbiol Immunol Infect. 2013;46(4):306–8. doi:10.1016/j.jmii.2012.10.001.

    Article  PubMed  Google Scholar 

  3. Carr MJ, Clarke S, O’Connell F, Sullivan DJ, Coleman DC, O’Connell B. First reported case of endocarditis caused by Candida dubliniensis. J Clin Microbiol. 2005;43(6):3023–6. doi:10.1128/JCM.43.6.3023-3026.2005.

    Article  PubMed  PubMed Central  Google Scholar 

  4. McMillan BD, Miller GJ, Nguyen J. Rare case of exogenous Candida dubliniensis endophthalmitis: a case report and brief review of the literature. J Ophthalmic Inflamm Infect. 2014;4:11. doi:10.1186/1869-5760-4-11.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Hospenthal DR, Beckius ML, Floyd KL, Horvath LL, Murray CK. Presumptive identification of Candida species other than C. albicans, C. krusei, and C. tropicalis with the chromogenic medium CHROMagar Candida. Ann Clin Microbiol Antimicrob. 2006;5:1. doi:10.1186/1476-0711-5-1.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Idelevich EA, Grunewald CM, Wullenweber J, Becker K. Rapid identification and susceptibility testing of Candida spp. from positive blood cultures by combination of direct MALDI-TOF mass spectrometry and direct inoculation of Vitek 2. PLoS ONE. 2014;9(12):e114834. doi:10.1371/journal.pone.0114834.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Ellepola AN, Hurst SF, Elie CM, Morrison CJ. Rapid and unequivocal differentiation of Candida dubliniensis from other Candida species using species-specific DNA probes: comparison with phenotypic identification methods. Oral Microbiol Immunol. 2003;18(6):379–88.

    Article  CAS  PubMed  Google Scholar 

  8. Tan AL, Wang GC, Chiu YW. Candida dubliniensis infection, Singapore. Emerg Infect Dis. 2002;8(4):445–6. doi:10.3201/eid0804.010423.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Miron D, Horowitz Y, Lumelsky D, Hanania S, Colodner R. Dual pulmonary infection with Candida dubliniensis and Aspergillus fumigatus in a child with chronic granulomatous disease. J Infect. 2005;50(1):72–5. doi:10.1016/j.jinf.2004.05.017.

    Article  PubMed  Google Scholar 

  10. Kalkanci A, Kokturk N, Senol E, Acar K, Guzel O, Sancak B, et al. Could Candida dubliniensis be involved in lung fungus balls? Rev Iberoam Micol. 2005;22(3):157–9.

    Article  PubMed  Google Scholar 

  11. Wahab AA, Taj-Aldeen SJ, Kolecka A, ElGindi M, Finkel JS, Boekhout T. High prevalence of Candida dubliniensis in lower respiratory tract secretions from cystic fibrosis patients may be related to increased adherence properties. Int J Infect Dis. 2014;24:14–9. doi:10.1016/j.ijid.2014.03.1380.

    Article  PubMed  Google Scholar 

  12. Kontoyiannis DP, Reddy BT, Torres HA, Luna M, Lewis RE, Tarrand J, et al. Pulmonary candidiasis in patients with cancer: an autopsy study. Clin Infect Dis. 2002;34(3):400–3. doi:10.1086/338404.

    Article  CAS  PubMed  Google Scholar 

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    Authors and Affiliations

    1. Department of Infectious Diseases and Global Health, University of Chicago Medical Center, Chicago, IL, USA

      Lindsay A. Petty, Jessica P. Ridgway & Jennifer Pisano

    2. Department of Pathology, University of Chicago Medical Center, 5841 South Maryland Ave, Chicago, IL, 60637, USA

      Alexander J. Gallan, Jordan A. Detrick & Jeffrey Mueller

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    1. Lindsay A. Petty
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    2. Alexander J. Gallan
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    3. Jordan A. Detrick
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    4. Jessica P. Ridgway
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    5. Jeffrey Mueller
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    6. Jennifer Pisano
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    Correspondence to Alexander J. Gallan.

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    Lindsay Petty, Alexander Gallan, Jordan Detrick, Jessica Ridgway, Jeffrey Mueller, and Jennifer Pisano declare that they have no conflicts of interest.

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    Lindsay A. Petty and Alexander J. Gallan have contributed equally to this work.

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    Petty, L.A., Gallan, A.J., Detrick, J.A. et al. Candida dubliniensis Pneumonia: A Case Report and Review of Literature. Mycopathologia 181, 765–768 (2016). https://doi.org/10.1007/s11046-016-0032-5

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    • DOI: https://doi.org/10.1007/s11046-016-0032-5

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