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The role of TRPV channels in osteoporosis

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Abstract

As the world’s population ages, the treatment of osteoporosis is a major problem to be addressed. The cause of osteoporosis remains unclear. Ca2+ is not only an important component of bones but also plays a key role in osteoporosis treatment. Transient receptor potential vanilloid (TRPV) channels are one of the TRP channel families that is widely distributed in various organs, playing an important role in the physiological regulation of the human body. Bone formation and bone absorption may require Ca2+ transport via TRPV channels. It has been proven that the TRPV subtypes 1, 2, 4, 5, 6 (TRPV1, TRPV2, TRPV4, TRPV5, TRPV6) may affect bone metabolism balance through selective regulation of Ca2+. They significantly regulate osteoblast/osteoclast proliferation, differentiation and function. The purpose of this review is to explore the mechanisms of TRPV channels involved in regulation of the differentiation of osteoblasts and osteoclasts, as well as to discuss the latest developments in current researches, which may provide new clues and directions for an in-depth study of osteoporosis and other related bone metabolic diseases.

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Acknowledgements

This work was supported by National Key Research and Development Project (No.2017YFB0403801); The Joint Special Program of Science and Technology Department of Yunnan Province and Kunming Medical University for applied basic research [No.2019FE001(-111)]; Application base project of Yunnan Science and Technology Department (No.2019FB097); Yunnan health training project of high level talents (No.D-2018005);Yunnan Fundamental Research Key Projects (No. 202101AS070046);Yunnan High-level Scientific and Technological Talent Platform Plan (No. 202105AC160064).

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  1. Na Liu and Weiwei Lu are co-first authors.

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  1. Department of Anesthesiology, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, China

    Na Liu

  2. Medical School, Kunming University of Science and Technology, Kunming, 650500, China

    Weiwei Lu & Xiaolin Dai

  3. Laser Medical Center, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 159 JinBi Road, Kunming, 650032, China

    Xiaowen Qu & Chongtao Zhu

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Liu, N., Lu, W., Dai, X. et al. The role of TRPV channels in osteoporosis. Mol Biol Rep 49, 577–585 (2022). https://doi.org/10.1007/s11033-021-06794-z

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