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Microwave-accelerated diastereoselective catalyst-free one-pot four-component synthesis of 2-(N-carbamoylacetamide)-substituted 2,3-dihydrothiophenes in glycerol

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Abstract

In the current study, glycerol was successfully employed as a nonvolatile, non-toxic, non-flammable, biodegradable, very cheap, easily accessible, and efficient reaction medium for the microwave-enhanced diastereoselective synthesis of 2-(N-carbamoylacetamide)-substituted 2,3-dihydrothiophenes via a catalyst-free one-pot four-component reaction. A versatile range of starting materials were used, and diverse products were obtained in good to excellent yields and very short reaction times. Moreover, the reaction medium was recovered and reused several times without any loss of the efficiency.

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Acknowledgements

Thanks are due to the Shiraz University Research Councils for the supporting of this work.

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Authors and Affiliations

  1. Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454, Iran

    Reza Kordnezhadian, Mohsen Shekouhy & Ali Khalafi-Nezhad

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  1. Reza Kordnezhadian
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  2. Mohsen Shekouhy
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  3. Ali Khalafi-Nezhad
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Correspondence to Mohsen Shekouhy or Ali Khalafi-Nezhad.

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Kordnezhadian, R., Shekouhy, M. & Khalafi-Nezhad, A. Microwave-accelerated diastereoselective catalyst-free one-pot four-component synthesis of 2-(N-carbamoylacetamide)-substituted 2,3-dihydrothiophenes in glycerol. Mol Divers 24, 737–751 (2020). https://doi.org/10.1007/s11030-019-09985-w

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