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The Mannich reaction in the synthesis of N,S-containing heterocycles 9. A new approach to thieno[2,3-d]pyrimidines

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Abstract

Upon treatment with p-toluidine and an excess of HCHO in hot DMF, 2-amino-5-benzoyl-4-(2-chlorophenyl)-4,5-dihydrothiophene-3-carbonitrile afforded 6-benzoyl-5-(2-chloro-phenyl)-3-(4-methylphenyl)-3,4,5,6-tetrahydrothieno[2,3-d]pyrimidine-4a (2H)-carbonitrile in 76% yield.

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References

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Authors and Affiliations

  1. Vladimir Dal’East-Ukrainian National University, 20a kv. Molodyozhnyi, 91034, Lugansk, Ukraine

    V. V. Dotsenko & S. G. Krivokolysko

  2. Physico-Chemical Department, State Enterprise Luganskstandartmetrologiya, 50 ul. Timiryazeva, 91021, Lugansk, Russia

    V. V. Dotsenko

  3. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    V. P. Litvinov

Authors
  1. V. V. Dotsenko
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  2. S. G. Krivokolysko
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  3. V. P. Litvinov
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Corresponding author

Correspondence to V. V. Dotsenko.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1479–1480, July, 2009.

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Dotsenko, V.V., Krivokolysko, S.G. & Litvinov, V.P. The Mannich reaction in the synthesis of N,S-containing heterocycles 9. A new approach to thieno[2,3-d]pyrimidines. Russ Chem Bull 58, 1524–1525 (2009). https://doi.org/10.1007/s11172-009-0206-0

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  • DOI: https://doi.org/10.1007/s11172-009-0206-0

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