Possible applications of dynamic light scatterring for measurement of the sizes of nanoparticles and their distributions by size are considered. Nanoparticles are added to a complex colloidal system (blood plasma or some other biological fluid) containing particles of similar sizes. The contribution of the added particles to the light scattering is found by the method of depolarized dynamic light scattering (for anisotropic particles) or by processing experimental data (for isotropic particles). Examples illustrating the determination of the sizes of gold nanoparticles and liposomes added to undiluted blood plasma are presented.
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Refereneces
M. A. Dobrovolskaia, A. K. Patri, J. Zhang, et al., “Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles,” Nanomed.: Nanotechnol., Biol. Med., 5, No. 2, 106–117 (2009).
S. H. DePaoli-Lacerda, J. J. Park, C. Meuse, et al., “Interaction of gold nanoparticles with common human blood protein,” ACS Nano, No. 1, 365–379 (2010).
W. Lai, Q. Wang, L. Li, et al., “Interaction of gold and silver nanoparticles with human plasma: Analysis of protein corono reveals specific binding patterns,” Colloids and Surf. B: Biointerf., 152, 317–325 (2017).
N. Ajdari, C. Vyas, S. L. Bogan, et al., “Gold nanoparticle interactions in human blood: A model evaluation,” Nanomed.: Nanotechnol., Biol. Med., 13, No. 4, 1531–1542 (2017).
Ye. A. Shmytkova, “Potential of the method of depolarized dynamic light scattering for determining the geometric parameters of aspherical nanoparticles,” Metrologiya, No. 10, 16–21 (2013).
S. Balog, L. Rodriguez-Lorenzo, C. A. Monnier, et al., “Characterizing nanoparticles in complex biological media and physiological fluids with depolarized dynamic light scattering,” Nanoscale, 7, 5991–5997 (2015).
J. Rodriguez-Fernandez, J. Perez-Juste, L. M. Liz-Marzan, and P. R. Lang, “Dynamic light scattering of short Au rods with low aspect ratios,” J. Phys. Chem., 111, No. 13, 5020–5025 (2007).
A. Kh. Vorob’ev, Diffusion Problems in Chemical Kinetics, Izd. MGU, Moscow (2003).
A. D. Levin, A. Yu. Sadagov, and E. A. Shmytkova, Patent 2630447 RF, “A method of determining the size of particles added to an initial colloidal solution,” Izobret. Polezn. Modeli, No. 25 (2017).
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Translated from Izmeritel’naya Tekhnika, No. 11, pp. 15–18, November, 2017.
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Levin, A.D., Sadagov, A.Y., Shchelkonogov, V.A. et al. Estimation of the Dimensions of Nanoparticles in Multicomponent Colloidal Sysems by Dynamic Light Scattering. Meas Tech 60, 1091–1096 (2018). https://doi.org/10.1007/s11018-018-1323-7
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DOI: https://doi.org/10.1007/s11018-018-1323-7