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Curcumin attenuates memory impairments and long-term potentiation deficits by damping hippocampal inflammatory cytokines in lipopolysaccharide-challenged rats

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Abstract

Neuroinflammation is a key pathological event triggering neurodegenerative process, resulting in neurologic sequelae. Curcumin (cur) has recently received increasing attention due to its anti-inflammatory properties. Therefore, we investigated the protective effects of curcumin on lipopolysaccharide (LPS)-induced memory impairments, long-term potentiation (LTP) deficits, hippocampal inflammatory cytokines, and neuronal loss in male rats. Rats were randomly divided into four groups as follows: (1) Vehicle; (2) cur; (3) LPS; and (4) cur/LPS. Following curcumin pretreatment (50 mg/kg, per oral via gavage, 14 consecutive days), animals received a single dose of LPS (1 mg/kg, intraperitoneally) or saline. Twenty-four hours after LPS/or saline administration, passive avoidance test (PAT), hippocampal LTP, inflammatory cytokines (TNFα, IL-1β), and neuronal loss were assessed in hippocampal tissue of rats. Our results indicated that pretreatment with curcumin in LPS-challenged rats attenuates memory impairment in PAT, which was accompanied by significant increase in the field excitatory post-synaptic potential (fEPSP) slope and population spike (PS) amplitude. Hence, pretreatment with curcumin in LPS-treated rats decreased hippocampal concentration of tumor necrosis factor-alpha (TNF-α) and interleukin-1β (IL-1β), as well as reduced neuronal loss in the hippocampal tissue. This study provide evidence that pretreatment with curcumin attenuates LPS-induced memory impairment and LTP deficiency, which may be partly related to the amelioration of inflammatory cytokines and neuronal loss in the hippocampal tissue.

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Funding

This work was funded by Ahvaz Jundishapur University of Medical Sciences, Ahvaz- Iran (Grant number: APRC-9812).

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  1. Somayeh Hajipour and Sadegh Moradi Vastegani contributed equally to this work.

Authors and Affiliations

  1. Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Somayeh Hajipour, Sadegh Moradi Vastegani, Alireza Sarkaki, Seyedeh Parisa Navabi, Yaghoob Farbood & Seyed Esmaeil Khoshnam

  2. Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

    Zahra Basir

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  1. Somayeh Hajipour
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  2. Sadegh Moradi Vastegani
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Contributions

S. H: Conceptualization, Writing—review & editing, Data curation, Visualization, Formal analysis. S. M. V.: Conceptualization, Writing—review & editing, Data curation, Visualization, Formal analysis. Z. B.: Investigation, Methodology, Data curation. A. S.: Methodology, Writing—review & editing. Y. F.: Methodology, Writing—review & editing. S. P. N.: Investigation, Methodology. S. E. K.: Supervision, Conceptualization, Writing—review & editing, Data curation, Visualization, Project administration, Funding acquisition, Formal analysis.

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Correspondence to Seyed Esmaeil Khoshnam.

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The study has been approved by the Ethics Committee of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran (Ethic code: IR.AJUMS.REC.1398.059). All experimental procedures were strictly carried out following the ethical guidelines.

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Hajipour, S., Vastegani, S.M., Sarkaki, A. et al. Curcumin attenuates memory impairments and long-term potentiation deficits by damping hippocampal inflammatory cytokines in lipopolysaccharide-challenged rats. Metab Brain Dis 38, 1379–1388 (2023). https://doi.org/10.1007/s11011-023-01169-8

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