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Evaluation of [99mTc]Tc-TTHMP as a SPECT imaging agent for skeletal system

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Abstract

TTHMP (triethylene-tetramine-hexamethylene-phosphonic acid) shows good bone-seeking ability in previous studies. In this research, [99mTc]Tc-TTHMP was prepared with the radiochemical yield of  98% and the possible application of [99mTc]Tc-TTHMP in skeletal system imaging was evaluated. The corresponding TTHMP kits have also been developed. [99mTc]Tc-TTHMP is hydrophilic and stable in saline and serum. The biodistribution data show [99mTc]Tc-TTHMP has a high uptake in the bone and is excreted rapidly through urinary system. Both micro-SPECT/CT imaging in normal mice and SPECT imaging in a normal Beagle dog confirm the results. It is suggested that [99mTc]Tc-TTHMP can be a candidate for skeletal system imaging.

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Acknowledgements

We thank the help from Professor Zhenin Li of Nuclear Medicine and Molecular Imaging Center of Soochow University for Micro-SPECT/CT imaging and the help from Professor Yue Chen of the First Affiliated Hospital of Southwest Medical University for SPECT imaging.

Funding

This work was supported by the CAEP Innovation and Development Foundation (Grand Number: CX20200003) and the Central Guidance for Local Science and Technology Development Projects (Grand Number: 202138-03).

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Author notes

  1. Hu Song and Guanquan Wang contribute equally to this work.

Authors and Affiliations

  1. Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang, 621999, China

    Hu Song, Guanquan Wang, Jing Wang, Xia Yang, Hongyuan Wei & Shunzhong Luo

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  1. Hu Song
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  2. Guanquan Wang
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  3. Jing Wang
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  4. Xia Yang
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Correspondence to Hu Song.

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All animal experiments were performed in compliance with the guidelines and protocols approved by the Animal Investigation Committee of Southwest Medical University (approval number: 20160796).

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Song, H., Wang, G., Wang, J. et al. Evaluation of [99mTc]Tc-TTHMP as a SPECT imaging agent for skeletal system. J Radioanal Nucl Chem 332, 2143–2148 (2023). https://doi.org/10.1007/s10967-023-08829-0

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  • DOI: https://doi.org/10.1007/s10967-023-08829-0

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