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Aspects of yield and specific activity of (n,γ) produced 177Lu used in targeted radionuclide therapy

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Abstract

177Lu-labeled receptor avid peptides and monoclonal antibodies have been effectively used in targeted tumor therapy, owing to the ideally suited decay properties and favourable production logistics of 177Lu [T½ = 6.65 days; Eβ(max) = 497 keV (78.6 %); Eγ = 208 keV (11.0 %)]. The specific activity of 177Lu produced by the (n,γ) route is one of the important criteria, which determines the efficacy of 177Lu-labeled receptor-avid biomolecules. The present article highlights that the specific activity of (n,γ) produced 177Lu cannot be calculated by simply dividing the produced activity by the mass of the target irradiated, unlike other (n,γ) produced medical radioisotopes and there is a significant enhancement of specific activity due to the burn up of the Lu target during irradiation, which is an added advantage towards the utilization of 177Lu in receptor specific therapeutic radiopharmaceuticals.

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References

  1. Cutler CS, Hennkens HM, Sisay N, Huclier-Markai S, Jurisson SS (2013) Chem Rev 113:858–883

    Article  CAS  Google Scholar 

  2. Das T, Pillai MRA (2013) Nucl Med Biol 40:23–32

    Article  CAS  Google Scholar 

  3. Banerjee S, Das T, Chakraborty S, Venkatesh M (2012) Radiochim Acta 100:115–126

    Article  CAS  Google Scholar 

  4. Kam BLR, Teunissen JJM, Krenning EP, de Herder WW, Khan S, van Vliet EI, Kwekkeboom DJ (2012) Eur J Nucl Med Mol Imaging 39(Suppl 1):S103–S112

    Article  Google Scholar 

  5. Kwekkeboom DJ, Bakker WH, Kam BL, Teunissen JJM, Kooij PPM, Herder WW, Feelders RA, Eijck CHJ, Jong M, Srinivisan A, Erion JL, Krenning EP (2003) Eur J Nucl Med Mol Imaging 30:417–422

    Article  CAS  Google Scholar 

  6. Das T, Bhadwal M, Banerjee S, Sarma HD, Shinto A, Kamaleshwaran KK (2014) J Radioanal Nucl Chem 299:1389–1398

    Article  CAS  Google Scholar 

  7. Bander NH, Milowsky MI, Nanus DM, Kostakoglu L, Vallabhajosula S, Goldsmith SJ (2005) J Clin Oncol 23:4591–4601

    Article  CAS  Google Scholar 

  8. Rasaneh S, Rajabi H, Babaei MH, Daha FJ, Salouti M (2009) Nucl Med Biol 36:363–369

    Article  CAS  Google Scholar 

  9. Kwekkeboom DJ, de Herder WW, Kam BL, van Eijck CH, van Essen M, Kooij PP, Feelders RA, van Aken MO, Krenning EP (2008) J Clin Oncol 26:2124–2130

    Article  CAS  Google Scholar 

  10. Esser JP, Krenning EP, Teunissen JJ, Kooij PP, van Gameren AL, Bakker WH, Kwekkeboom DJ (2006) Eur J Nucl Med Mol Imaging 33:1346–1351

    Article  CAS  Google Scholar 

  11. Das T, Chakraborty S, Banerjee S, Venkatesh M (2007) Appl Radiat Isot 65:301–308

    Article  CAS  Google Scholar 

  12. Kwekkeboom DJ, Bakker WH, Kooij PPM, Konijnenberg MW, Srinivasan A, Erion JL, Schmidt MA, Bugaj JL, de Jong M, Krenning EP (2001) Eur J Nucl Med 28:1319–1325

    Article  CAS  Google Scholar 

  13. Chakravarty R, Das T, Dash A, Venkatesh M (2010) Nucl Med Biol 37:811–820

    Article  CAS  Google Scholar 

  14. Pillai MRA, Chakraborty S, Das T, Venkatesh M, Ramamoorthy N (2003) Appl Radiat Isot 59:109–118

    Article  CAS  Google Scholar 

  15. Chakraborty S, Vimalnath KV, Sharad P Lohar, Priyalata Shetty, Ashutosh Dash (2014) J Radioanal Nucl Chem DOI 10.1007/s10967-014-3169-z

  16. Atlas of neutron capture cross sections (1997) IAEA Nuclear Data Section, Vienna

  17. Dvorakova Z, Henkelmann R, Lin X, Türler A, Gerstenberg H (2008) Appl Radiat Isot 66:147–151

    Article  CAS  Google Scholar 

  18. Zhernosekov KP, Perego RC, Dvorakova Z, Henkelmann R, Türler A (2008) Appl Radiat Isot 66:1218–1220

    Article  CAS  Google Scholar 

Download references

Acknowledgments

Research at the Bhabha Atomic Research Centre is part of the ongoing activities of the Department of Atomic Energy, India and fully supported by government funding. The authors are grateful to Dr. Gursharan Singh, Head, Isotope Application and Radiopharmaceuticals Division, Bhabha Atomic Research Centre, for his support. The authors express sincere gratitude to Dr. Ashok Goswami, Head, Radiochemistry Division, Bhabha Atomic Research Centre, for his support in the analysis of samples using ICP-AES technique. The authors are also thankful to the staff members of Irradiation Co-ordination Group of Isotope Application and Radiopharmaceuticals Division for their help.

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Authors and Affiliations

  1. Isotope Application and Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India

    K. V. Vimalnath, Priyalata Shetty, Sharad P. Lohar, Sudipta Chakraborty & Ashutosh Dash

  2. Radiochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India

    V. C. Adya & S. K. Thulasidas

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  1. K. V. Vimalnath
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  2. Priyalata Shetty
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  3. Sharad P. Lohar
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  5. S. K. Thulasidas
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  6. Sudipta Chakraborty
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  7. Ashutosh Dash
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Correspondence to Sudipta Chakraborty.

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Vimalnath, K.V., Shetty, P., Lohar, S.P. et al. Aspects of yield and specific activity of (n,γ) produced 177Lu used in targeted radionuclide therapy. J Radioanal Nucl Chem 302, 809–812 (2014). https://doi.org/10.1007/s10967-014-3240-9

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  • DOI: https://doi.org/10.1007/s10967-014-3240-9

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