Skip to main content
SpringerLink
Log in

Micellization and Interfacial Behavior of the Sodium Salt of Ibuprofen–BRIJ-58 in Aqueous/Brine Solutions

  • Published:
Journal of Solution Chemistry Aims and scope Submit manuscript

Abstract

This work deals with the effect of a nonionic surfactant (BRIJ-58) on the physicochemical properties of the sodium salt of ibuprofen, in the absence and presence of salt (NaCl), in order to understand the nature of interactions in IBF–BRIJ-58 aqueous mixtures. Tensiometric measurements were carried out to estimate the critical micelle concentrations (cmc) of drug and surfactant along with their mixtures. A gradual reduction in the surface charge of the micelles was obtained by adding salt followed by the early formation of the micelles; hence, the cmc value of the amphiphiles decreased. Various parameters such as micellar, interfacial, corresponding thermodynamic parameters, etc., have been calculated and are discussed in detail by applying various theoretical models reported in the literature. The theories of Clint, Rubingh, Motomura and Maeda have been applied to investigate interactions among the components. Structural parameters proposed by Tanford have also been also evaluated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Rosen, M.J.: Surfactants and Interfacial Phenomena. Wiley, New York (2004)

    Book  Google Scholar 

  2. Myers, D.: Surfactant Science and Technology. Wiley, Hoboken (2006)

    Google Scholar 

  3. Abe, M., Ogino, K.: Mixed Surfactant Systems. Marcel Dekker, New York (1993)

    Google Scholar 

  4. Rub, M.A., Azum, N., Kumar, D., Khan, F., Asiri, A.M.: Clouding phenomenon of amphiphilic drug promazine hydrochloride solutions: influence of pharmaceutical excipients. J. Ind. Eng. Chem. 21, 1119–1126 (2015)

    Article  CAS  Google Scholar 

  5. Naqvi, A.Z., Rub, M.A., Din, K.: Study of phospholipid induced phase separation in amphiphilic drugs. Colloid J. 77, 525–531 (2015)

    Article  CAS  Google Scholar 

  6. Azum, N., Rub, M.A., Asiri, A.M.: Energetics of clouding phenomenon in amphiphilic drug imipramine hydrochloride with pharmaceutical excipients. Pharm. Chem. J. 48, 201–208 (2014)

    Article  CAS  Google Scholar 

  7. Azum, N., Rub, M.A., Asiri, A.M., Akram, M.: Aggregation and microenvironmental properties of gemini and conventional mixed surfactants systems: a fluorometric study. Russ. J. Phys. Chem. B 9, 940–945 (2015)

    Article  CAS  Google Scholar 

  8. Rub, M.A., Kumar, D., Azum, N., Khan, F., Asiri, A.M.: Study of the interaction between promazine hydrochloride and surfactant (conventional/gemini) mixtures at different temperatures. J. Solution Chem. 43, 930–949 (2014)

    Article  Google Scholar 

  9. Azum, N., Rub, M.A., Asiri, A.M., Marwani, H.M.: Study of the interactions in dicationic gemini-anionic conventional mixed surfactant systems in the viewpoint of regular solution theory. J. Mol. Liquids 197, 339–345 (2014)

    Article  CAS  Google Scholar 

  10. Azum, N., Rub, M.A., Asiri, A.M., Alamry, K.A., Marwani, H.M.: Self-aggregation of cationic dimeric and anionic monomeric surfactants with nonionic surfactant in aqueous medium. J. Disp. Sci. Technol. 35, 358–363 (2014)

    Article  CAS  Google Scholar 

  11. Azum, N., Rub, M.A., Asiri, A.M.: Analysis of surface and bulk properties of amphiphilic drug ibuprofen and surfactant mixture in the absence and presence of electrolyte. Colloids Surf. B 121, 158–164 (2014)

    Article  CAS  Google Scholar 

  12. Rub, M.A., Azum, N., Asiri, A.M., Khan, A., Khan, A.A.P., Rehman, M.M., Khan, S.B.: Micellization of amphiphilic drug with pharmaceutical excipients in aqueous electrolytic solution: composition, interaction, and stability of the aggregates. J. Disp. Sci. Technol. 35, 1588–1598 (2014)

    Article  CAS  Google Scholar 

  13. Rub, M.A., Azum, N., Khan, S.B., Marwani, H.M., Asiri, A.M.: Micellization behavior of amphiphilic drug promazine hydrochloride and sodium dodecyl sulfate mixtures at various temperatures: effect of electrolyte and urea. J. Mol. Liquids 212, 532–543 (2015)

    Article  Google Scholar 

  14. Azum, N., Rub, M.A., Asiri, A.M., Khan, A.A.P., Khan, A., Khan, S.B., Rahman, M.M., Al-Youbi, A.O.: Interaction of amphiphilic drug amitriptyline hydrochloride with surfactants (gemini/conventional): a physicochemical approach. J. Solution Chem. 42, 1532–1544 (2013)

    Article  CAS  Google Scholar 

  15. Dar, A.A., Rather, G.M., Das, A.R.: Mixed micelle formation and solubilization behaviour towards poly-cyclic aromatic hydrocarbons of binary and ternary cationic nonionic surfactant mixtures. J. Phys. Chem. B 111, 3122–3132 (2007)

    Article  CAS  Google Scholar 

  16. Chakraborty, T., Ghosh, S., Moulik, S.P.: Micellization and related behavior of binary and ternary surfactant mixtures in aqueous medium: cetyl pyridinium chloride (CPC), cetyl trimethyl ammonium bromide (CTAB) and polyoxyethylene (10) cetyl ether (Brij–56) derived system. J. Phys. Chem. B 109, 14813–14823 (2005)

    Article  CAS  Google Scholar 

  17. Ghosh, S., Moulik, S.P.: Interfacial and micellization behavior of binary and ternary mixtures of amphiphiles (Tween-20, Brij-35, and sodium dodecyl sulfate) in aqueous medium. J. Colloid Interface Sci. 208, 357–366 (1998)

    Article  CAS  Google Scholar 

  18. Rub, M.A., Azum, N., Khan, F., Al-Sehemi, A.G., Asiri, A.M.: Micellization behavior of mixtures of amphiphilic promazine hydrochloride and cationic aniline hydrochloride in aqueous and electrolyte solutions. Korean J. Chem. Eng. 32, 2141–2151 (2015)

    Article  Google Scholar 

  19. Moulik, S.P., Haque, M.E., Jana, P.K., Das, A.R.: Micellar properties of cationic surfactants in pure and mixed states. J. Phys. Chem. 100, 701–708 (1996)

    Article  CAS  Google Scholar 

  20. Rub, M.A., Azum, N., Khan, S.B., Khan, F., Asiri, A.M.: Physicochemical properties of amphiphilic drug and anionic surfactant mixtures: experimental and theoretical approach. J. Disp. Sci. Technol. 36, 521–531 (2015)

    Article  CAS  Google Scholar 

  21. Song, L.D., Rosen, M.J.: Surface properties, micellization, and premicellar aggregation of Gemini surfactants with rigid and flexible spacers. Langmuir 12, 1149–1153 (1996)

    Article  CAS  Google Scholar 

  22. Rub, M.A., Khan, F., Azum, N., Asiri, A.M., Marwani, H.M.: Micellization phenomena of amphiphilic drug and TX-100 mixtures: fluorescence, UV-visible and 1H NMR study. J. Taiwan Inst. Chem. Eng. 60, 32–43 (2016)

    Article  Google Scholar 

  23. Davis, J.T., Rideal, E.K.: Interfacial Phenomena. Academic Press, New York (1963)

    Google Scholar 

  24. Borwankar, R.P., Wanson, D.T.: Equilibrium and dynamics of adsorption of surfactants at fluid–fluid interfaces. Chem. Eng. Sci. 43, 1323–1337 (1988)

    Article  CAS  Google Scholar 

  25. Clint, J.H.: Surfactant Aggregation. Chapman and Hall, New York (1992)

    Book  Google Scholar 

  26. Rubingh, D.N.: Solution Chemistry of Surfactants. Plenum, New York (1979)

    Google Scholar 

  27. Motomura, K., Aratono, M.: Mixed Surfactant Systems. Marcel Dekker, New York (1998)

    Google Scholar 

  28. Maeda, H.: A simple thermodynamic analysis of the stability of ionic/nonionic mixed micelles. J. Colloid Interface Sci. 172, 98–105 (1995)

    Article  CAS  Google Scholar 

  29. Ghosh, S.: Surface chemical and micellar properties of binary and ternary surfactant mixtures (cetyl pyridinium chloride, Tween-40, and Brij-56) in an aqueous medium. J. Colloid Interface Sci. 244, 128–138 (2001)

    Article  CAS  Google Scholar 

  30. Goworek, J., Stefaniak, W.: Characteristics of the pore structure of silica gels by thermogravimetric desorption of liquids. Colloids Surf. 55, 359–364 (1991)

    Article  CAS  Google Scholar 

  31. Tanford, C.: The Hydrophobic Effect: Formation of Micelles and Biological Membranes. Wiley, New York (1980)

    Google Scholar 

  32. Tsubone, K., Arakawa, Y., Rosen, M.J.: Structural effects on surface and micellar properties of alkanediyl-α, ω-bis(sodium N-acyl-β-alaninate) gemini surfactants. J. Colloid Interface Sci. 262, 516–524 (2003)

    Article  CAS  Google Scholar 

  33. Miller, R., Grigoriev, D., Krägel, J., Makievski, A.V., Fainerman, V.B., Kovalchuk, V.I., Liggieri, L., Ravera, F., Ferrari, M., Santini, E., Loglio, G., Dutschk, V., Karapantsios, T.: Project proposal for the investigation of particle-stabilised emulsions and foams by microgravity experiments. Microgravity Sci. Technol. 18, 104–107 (2006)

    Article  CAS  Google Scholar 

  34. Miller, R., Dutschk, V., Fainerman, V.B.: Influence of molecular processes at liquid interfaces on dynamic surface tensions and wetting kinetics. J. Adhesion 80, 549–561 (2004)

    Article  CAS  Google Scholar 

  35. Sugihara, G., Miyazono, A.M., Nagadome, S., Oida, T., Hayashi, Y., Ko, J.S.: Adsorption and micelle formation of mixed surfactant systems in water II: a combination of cationic gemini-type surfactant with mega-10. J. Oleo Sci. 52, 449–461 (2003)

    Article  CAS  Google Scholar 

  36. Hall, D.G.: Electrostatic effects in dilute solutions containing charged colloidal entities. J. Chem. Soc., Faraday Trans. 87, 3529–3535 (1991)

    Article  CAS  Google Scholar 

  37. Azum, N., Rub, M.A., Asiri, A.M.: Experimental and theoretical approach to mixed surfactant system of cationic gemini surfactant with nonionic surfactant in aqueous medium. J. Mol. Liquids 196, 14–20 (2014)

    Article  CAS  Google Scholar 

  38. Al-Muhanna, M.K., Rub, M.A., Azum, N., Khan, S.B., Asiri, A.M.: Self-aggregation phenomenon of promazine hydrochloride under the influence of sodium cholate/sodium deoxycholate in aqueous medium. J. Disp. Sci. Technol. 37, 450–463 (2016)

    Article  CAS  Google Scholar 

  39. Khan, F., Rub, M.A., Azum, N., Kumar, D., Asiri, A.M.: Interaction of an amphiphilic drug and sodium bis(2-ethylhexyl)sulfosuccinate at low concentrations in the absence and presence of sodium chloride. J. Solution Chem. 44, 1937–1961 (2015)

    Article  CAS  Google Scholar 

  40. Rub, M.A., Khan, F., Sheikh, M.S., Azum, N., Asiri, A.M.: Tensiometric, fluorescence and 1H NMR study of mixed micellization of non-steroidal anti-inflammatory drug sodium salt of ibuprofen in the presence of non-ionic surfactant in aqueous/urea solutions. J. Chem. Thermodyn. 96, 196–207 (2016)

    Article  Google Scholar 

  41. Azum, N., Rub, M.A., Asiri, A.M.: Micellization and interfacial behavior of binary and ternary mixtures in aqueous medium. J. Mol. Liquids 216, 94–98 (2016)

    Article  CAS  Google Scholar 

  42. Rub, M.A., Azum, N., Asiri, A.M.: Interaction of cationic amphiphilic drug nortriptyline hydrochloride with TX-100 in aqueous and urea solutions and the studies of physicochemical parameters of the mixed micelles. J. Mol. Liquids 218, 595–603 (2016)

    Article  Google Scholar 

  43. Azum, N., Rub, M.A., Asiri, A.M.: Self-Association and micro-environmental properties of sodium salt of ibuprofen with BRIJ-56 under the influence of aqueous/urea solution. J. Disp. Sci. Technol. (2016). doi:10.1080/01932691.2016.1144197

    Google Scholar 

Download references

Acknowledgments

This project was funded by the Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, Jeddah, under Grant no. CEAMR-SG-11-437.

Author information

Authors and Affiliations

  1. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    Naved Azum, Malik Abdul Rub & Abdullah M. Asiri

  2. Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    Naved Azum, Malik Abdul Rub & Abdullah M. Asiri

Authors
  1. Naved Azum
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Malik Abdul Rub
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Abdullah M. Asiri
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Naved Azum.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Azum, N., Rub, M.A. & Asiri, A.M. Micellization and Interfacial Behavior of the Sodium Salt of Ibuprofen–BRIJ-58 in Aqueous/Brine Solutions. J Solution Chem 45, 791–803 (2016). https://doi.org/10.1007/s10953-016-0463-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10953-016-0463-0

Keywords

Search

Navigation