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Interaction of an Amphiphilic Drug and Sodium Bis(2-ethylhexyl)sulfosuccinate at Low Concentrations in the Absence and Presence of Sodium Chloride

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Abstract

In the present study mixed micelles of the amphiphilic phenothiazine drug promazine hydrochloride (PMZ) and the anionic surfactant sodium bis(2-ethylhexyl)sulfosuccinate (AOT) have been studied using conductometry at different compositions and temperatures in aqueous as well as aqueous electrolyte (25 mmol·kg−1 NaCl) solutions to determine various physicochemical properties of the solutions. The experimental and ideal critical micelle concentration (CMC and CMC id) values suggest attractive interactions in PMZ–AOT mixed systems. The negative values of interaction parameter (β) obtained from regular solution theory indicate synergistic interactions; the negative values of β decrease further with the addition of salt. From the CMC values obtained as a function of temperature, various other thermodynamic properties have been evaluated.

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Acknowledgments

Center of Excellence for Advanced Materials Research and Chemistry Department, King Abdulaziz University, Jeddah are highly acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Aligarh Muslim University, Aligarh, 202 002, India

    Farah Khan

  2. Chemistry Department, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    Malik Abdul Rub, Naved Azum & Abdullah M. Asiri

  3. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    Malik Abdul Rub, Naved Azum & Abdullah M. Asiri

  4. Faculty of Science, Universiti Tunku Abdul Rahman, 31900, Kampar, Perak, Malaysia

    Dileep Kumar

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  1. Farah Khan
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  2. Malik Abdul Rub
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  3. Naved Azum
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Correspondence to Farah Khan.

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Khan, F., Rub, M.A., Azum, N. et al. Interaction of an Amphiphilic Drug and Sodium Bis(2-ethylhexyl)sulfosuccinate at Low Concentrations in the Absence and Presence of Sodium Chloride. J Solution Chem 44, 1937–1961 (2015). https://doi.org/10.1007/s10953-015-0386-1

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