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Curdlan/Clay Nanocomposite-Reinforced Alginate Beads as Drug Carriers

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Abstract

Dual crosslinked interpenetrating polymer network (IPN) beads of sodium alginate reinforced with curdlan-grafted poly-N-isopropylacrylamide/montmorillonite [Cud-g-PNIPA-/MMT] nanocomposites were accomplished for effective delivery of erlotinib HCl (ERL) to triple-negative breast cancer (TNBC) cells. Different beads exhibited variable size (1.30–1.47 mm) and excellent drug entrapment efficiency (DEE, 49.35–93.01%), which were influenced by the contents of reinforcing clay (MMT) in the composites. The SEM photographs also displayed the spherical morphology of the beads, and the results of infrared, thermal, and X-ray diffraction studies conferred a compatible environment of ERL in the matrices. Moreover, the sustained drug release profiles (Q8h, 73.79–84.24%) of various matrices were best fitted in the Korsmeyer-Peppas kinetic model with Fickian diffusion-driven mechanism. Furthermore, the beads demonstrated temperature-responsive swelling behavior and their molar masses between crosslinks (\(\bar{M}\)c) estimated by Flory-Rehner equation were enhanced with temperature. The beads containing 20% MMT (F-3) displayed a faster biodegradability than the control matrices (F-1, 0% MMT). The mucin adsorption ability of F-1 and F-3 followed Freundlich isotherm and Langmuir isotherm, respectively. As compared to pristine drug, F-3 bestowed an increased sensitivity on MDA-MB-231 cells. Thus, the Cud/alginate IPN beads could be employed as efficient drug carriers for TNBC therapy.

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The authors declare that the data supporting the findings of this study are available within the paper.

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Funding

The present work received funding from fellowship of China Postdoctoral Science Foundation (grant no. 2021MD703857; grant recipient, Dr. Hriday Bera).

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  1. Yasir Faraz Abbasi and Abhimanyu Thakur have contributed equally to this work.

Authors and Affiliations

  1. Dr. B.C. Roy College of Pharmacy and Allied Health Sciences, Durgapur, 713206, India

    Hriday Bera

  2. Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110013, Liaoning, China

    Hriday Bera & Yasir Faraz Abbasi

  3. Centre for Regenerative Medicine & Health, Hong Kong Institute of Science and Innovation, CAS Limited, Science Park, Shatin, Hong Kong, China

    Abhimanyu Thakur

  4. Pritzker School of Molecular Engineering, Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA

    Abhimanyu Thakur

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Bera, H., Abbasi, Y.F. & Thakur, A. Curdlan/Clay Nanocomposite-Reinforced Alginate Beads as Drug Carriers. J Polym Environ 32, 854–869 (2024). https://doi.org/10.1007/s10924-023-03036-0

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