Skip to main content
SpringerLink
Log in

In Vivo and In Vitro Biological and Histological Evaluation of Cordierite-Hydroxyapatite Ceramic Grafting Powder During Maxillary Sinus Augmentation in Rabbit Model

  • Research
  • Published:
Journal of Inorganic and Organometallic Polymers and Materials Aims and scope Submit manuscript

Abstract

This work aims to develop a bioactive ceramic substance to be used as a graft during maxillary sinus augmentation. Cordierite was created by sintering at 1400 °C a combination of 51.4% silica, 34.8% alumina, and 13.8% magnesia. X-ray Diffraction (XRD) was used to identify the manufactured chemical, and patterns revealed that indialite was identified as the predominate phase. Prepared cordierite had been mixed with hydroxyapatite to form three batches of cordierite:hydroxyapatite (Cor:HA). They were (50:50), (40:60), and (30:70), representing the first, second, and third batch respectively. Then, each batch had been sintered at 700, 900, and 1100 °C to get a new ceramic material. XRD analysis for the sintered samples indicates the presence of whitlockite phase in addition to HA and cordierite. To investigate the microstructure of manufactured samples, scanning electron microscope (SEM) was used. After 21 days of soaking to estimate degradability, data reveal that degradation rate substantially increased with increasing soaking period. The sample comprising 30:70 of (Cor:HA) and sintered at 1100 °C (Z7) employing the greatest degradability of around 34.53% after three weeks. The bioactivity outcomes showed that all grafts were bioactive, as indicated by the detection of apatite spheres using a Field Emission Scanning Electron Microscope. Also, apatite formation was confirmed via Energy Dispersive X-ray (EDX) shows appearance of Ca, P, O, and H peaks. Also, antibacterial and histological analysis were performed. As a result, Z7 grafting powder shows unique in vivo and in vitro behavior, in term of bioactivity, bacterial activity and bone formation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13
Fig. 14
Fig. 15
Fig. 16
Fig. 17
Fig. 18
Fig. 19
Fig. 20
Fig. 21

Similar content being viewed by others

Data Availability

The data are available in the manuscript.

References

  1. Z.J. Kadhim, F.J. Al-Hasani, E.S. Al-hassani, Investigation the bioactivity of cordierite/hydroxyapatite ceramic material used in bone regeneration. SILICON (2023). https://doi.org/10.1007/s12633-023-02539-8

    Article  Google Scholar 

  2. Z.J. Kadhim, F.J. Mohammed, E.S. Al-hassani, Effect of cordierite additions on mechanical properties of hydroxyapatite used in medical applications. Eng Technol J 41(6), 807–821 (2023). https://doi.org/10.30684/etj.2023.138142.1375

    Article  Google Scholar 

  3. M. Nadafan, R. Malekfar, Z. Dehghani, Structural and optical properties of cordierite glass-ceramic doped in polyurethane matrix. AIP Adv 5(6), 067135 (2015). https://doi.org/10.1063/1.4922838

    Article  CAS  Google Scholar 

  4. H. Ismail, H. Mohamad, Preliminary study on the bioactivity properties of cordierite/Β-wollastonite biocomposite ceramics. Key Eng Mater 908, 148–153 (2022). https://doi.org/10.4028/p-o96487

    Article  Google Scholar 

  5. Q. Hou, X. Luo, X. Liu, Z. Xie, Preparation of cordierite powder by chemical coprecipitation–rotation evaporation and solid reaction sintering. J Aust Ceram Soc 56, 1575–1582 (2020). https://doi.org/10.1007/s41779-020-00496-8

    Article  CAS  Google Scholar 

  6. P. Mengucci, G. Majni, A. De Benedittis, G. Biagini, M. Mattioli-Belmonte, Study of the interface reactions between cells and a biocompatible ceramic. Biomaterials 19(16), 1447–1450 (1998). https://doi.org/10.1016/s0142-9612(98)00056-8

    Article  CAS  PubMed  Google Scholar 

  7. A. Krajewski, A. Ravaglioli, M. Kirsch, G. Biagini, R. Solmi, M. Belmonte, L. Orlandi, Ceramic support for cell cultures. J Mater Sci Mater Med 7, 99–102 (1996). https://doi.org/10.1007/BF00058720

    Article  CAS  Google Scholar 

  8. L. Orlandi, R. Solmi, A. Krajewski, A. Bearzatto, G. Biagini, E. Ciccopiedi, A cell growth on cordierite: an approach to the identification of reliable supports for continuous-flow solid-bed reactors. Biomaterials 18(14), 955–961 (1997). https://doi.org/10.1016/s0142-9612(96)00201-33

    Article  CAS  PubMed  Google Scholar 

  9. C. Stacchi, S. Spinato, T. Lombardi, F. Bernardello, C. Bertoldi, D. Zaffe, M. Nevins, Minimally invasive management of implant-supported rehabilitation in the posterior maxilla, Part II. Surgical techniques and decision tree. Int J Periodontics Restor Dent 40(3), 85–93 (2020). https://doi.org/10.11607/prd.4497

    Article  Google Scholar 

  10. W. Lawson, Z. Patel, F. Lin, The development and pathologic processes that influence maxillary sinus pneumatization. Anat Rec Adv Integr Anat Evol Biol 291(11), 1554–1563 (2008). https://doi.org/10.1002/ar.20774

    Article  Google Scholar 

  11. M.A. Shuman, A.A.H. El-Feky, The efficacy of ridge preservation on maxillary sinus pneomatization and alveolar bone resoorption after extraction of posterior maxillary teeth. Egypt Dent J 67(2), 1069–1076 (2021)

    Article  Google Scholar 

  12. G. Ghidrai. “Sinus Lift,” Infodentis.com, dental procedures explained [Online]. 2023. https://www.infodentis.com/index-eng.php. Accessed 14 Jul 2023

  13. M.M. Shukur, A.M. Aswad, J.Z. Khadhim, Preparation of cordierite ceramic from Iraqi raw materials. Int J Eng Technol 5(3), 172–175 (2015)

    Google Scholar 

  14. S. Sadeghzade, R. Emadi, F. Tavangarian, M. Naderi, Fabrication and evaluation of silica-based ceramic scaffolds for hard tissue engineering applications. Mater. Sci. Eng. C 71, 431–438 (2017). https://doi.org/10.1016/j.msec.2016.10.042

    Article  CAS  Google Scholar 

  15. K. Abdali, Structural, morphological, and gamma ray shielding (GRS) characterization of HVCMC/PVP/PEG polymer blend encapsulated with silicon dioxide nanoparticles. SILICON 14(14), 9111–9116 (2022). https://doi.org/10.1007/s12633-022-01678-8

    Article  CAS  Google Scholar 

  16. M. Canillas, P. Pena, H. Antonio, M. Rodríguez, Calcium phosphates for biomedical applications. Boletín de la Sociedad Española de Cerámica y Vidrio 56(3), 91–112 (2017). https://doi.org/10.1016/j.bsecv.2017.05.001

    Article  CAS  Google Scholar 

  17. E. Al-Bermany, A.T. Mekhalif, H.A. Banimuslem et al., Effect of green synthesis bimetallic Ag@SiO2 core–shell nanoparticles on absorption behavior and electrical properties of PVA-PEO nanocomposites for optoelectronic applications. SILICON (2023). https://doi.org/10.1007/s12633-023-023327

    Article  PubMed Central  Google Scholar 

  18. Y. Ramaswamy, C. Wu, H. Zhou, H. Zreiqat, Biological response of human bone cells to zinc-modified Ca-Si-based ceramics. Acta Biomater. 4(5), 1487–1497 (2008). https://doi.org/10.1016/j.actbio.2008.04.014

    Article  CAS  PubMed  Google Scholar 

  19. W.D. Callister Jr., D.G. Rethwisch, Fundamentals of materials science and engineering: an integrated approach (Wiley, New York, 2020)

    Google Scholar 

  20. D. Bhavsar, V. Patel, K. Sawant, Systematic investigation of in vitro and in vivo safety, toxicity and degradation of mesoporous silica nanoparticles synthesized using commercial sodium silicate. Microporous Mesoporous Mater. 284, 343–352 (2019). https://doi.org/10.1016/j.micromeso.2019.04.050

    Article  CAS  Google Scholar 

  21. J. Zhao, Y. Liu, W.B. Sun, X. Yang, First detection, characterization, and application of amorphous calcium phosphate in dentistry. J Dent Sci 7(4), 316–323 (2012). https://doi.org/10.1016/j.jds.2012.09.001

    Article  Google Scholar 

  22. D.E. Radulescu, I.A. Neacsu, A.M. Grumezescu, E. Andronescu, Novel trends into the development of natural hydroxyapatite-based polymeric composites for bone tissue engineering. Polymers 14(5), 899 (2022). https://doi.org/10.3390/polym14050899

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. C. Köse, Characterization of weld seam surface and corrosion behavior of laser-beam-welded AISI 2205 duplex stainless steel in simulated body fluid. J. Mater. Sci. 55(36), 17232–17254 (2020). https://doi.org/10.1007/s10853-020-05326-7

    Article  CAS  Google Scholar 

  24. C. Gao, M. Yao, S. Peng, W. Tan, C. Shuai, Pre-oxidation induced in situ interface strengthening in biodegradable Zn/nano-SiC composites prepared by selective laser melting. J. Adv. Res. 38, 143–155 (2022). https://doi.org/10.1016/j.jare.2021.09.014

    Article  CAS  PubMed  Google Scholar 

  25. O.A. Golovanova, S.A. Gerk, Structural and morphological characteristics and dissolution behavior of carbonate hydroxyapatite prepared in the presence of proline. Inorg. Mater. 56, 543–551 (2020). https://doi.org/10.1134/S0020168520050039

    Article  CAS  Google Scholar 

  26. Q.A. Hamad, F.J. Al-Hasani, N.K. Faheed, Comparative study of biotin and hydroxyapatite on biological properties of composite coating. Int J Biomater (2022). https://doi.org/10.1155/2022/8802111

    Article  PubMed  PubMed Central  Google Scholar 

  27. K. Abdali, K.H. Abass, E. Al-Bermany, E.M. Al-robayi, A.M. Kadim, Morphological, optical, electrical characterizations and anti-escherichia coli bacterial efficiency (AECBE) of PVA/PAAm/PEO polymer blend doped with silver NPs. Nano Biomed Eng 14(2), 114–122 (2022). https://doi.org/10.5101/nbe.v14i2.p114-122

    Article  CAS  Google Scholar 

  28. S.I. Salih, J.K Oleiwi, H.M. Ali, Development the physical properties of polymeric blend (SR/ PMMA) by adding various types of nanoparticles, used for maxillofacial prosthesis applications. Eng Technol J 37(4), 120–129 (2019). https://doi.org/10.30684/etj.37.4A.2

    Article  Google Scholar 

  29. Z.Z. Ali, F.J. Al-Hasani,  Effect of ZrO2 and Y2O3 deposition on biological behavior of Ti-base alloys. Eng Technol J 39(4), 573–585 (2021). https://doi.org/10.30684/etj.v39i4A.190

    Article  Google Scholar 

  30. Z.M. Al-Rashidy, A.E. Omar, T.H.A. El-Aziz, M.M. Farag, In vivo bioactivity assessment of strontium-containing soda-lime-borate glass implanted in femoral defect of rat. J. Inorg. Organomet. Polym Mater. 30, 3953–3964 (2020). https://doi.org/10.1007/s10904-020-01535-4

    Article  CAS  Google Scholar 

  31. R.A. Youness, M.S. Amer, M.A. Taha, Comprehensive in vivo and in vitro studies for evaluating the bone-bonding ability of Na2O–CaO–SiO2–B2O3–Ag2O glasses for fracture healing applications. J Inorg Organomet Polym Mater (2023). https://doi.org/10.1007/s10904-023-02626-8

    Article  Google Scholar 

  32. D. Li, L. Zhao, M. Cong, L. Liu, G. Yan, Z. Li, B. Yang, Injectable thermosensitive chitosan/gelatin-based hydrogel carried erythropoietin to effectively enhance maxillary sinus floor augmentation in vivo. Dent. Mater. 36(7), e229–e240 (2020). https://doi.org/10.1016/j.dental.2020.04.016

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The Department of Materials Engineering at the University of Technology, the Ceramic and Building Materials/College of Materials Engineering at Babylon University, and the Departments of Surgery and Obstetrics and College of Veterinary Medicine et al.—Qasim Green University are all recipients of heartfelt thanks from the authors for their support of this work.

Funding

No funding applied.

Author information

Authors and Affiliations

  1. Materials Engineering Department, University of Technology, Baghdad, Iraq

    Zainab Jawad Kadhim, Fatimah J. Al-Hasani & Emad S. Al-hassani

Authors
  1. Zainab Jawad Kadhim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fatimah J. Al-Hasani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Emad S. Al-hassani
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

ZJK: Experiments were carried out, original draft authoring, data curation, and preparation. FJA: Developed the tests, planned them, reviewed and edited the article. ESA: Editing, visualizing, and reviewing.

Corresponding author

Correspondence to Zainab Jawad Kadhim.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethics Approval

Not applicable.

Consent to Participate

Not applicable.

Consent for Publication

Not applicable.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kadhim, Z.J., Al-Hasani, F.J. & Al-hassani, E.S. In Vivo and In Vitro Biological and Histological Evaluation of Cordierite-Hydroxyapatite Ceramic Grafting Powder During Maxillary Sinus Augmentation in Rabbit Model. J Inorg Organomet Polym 34, 401–418 (2024). https://doi.org/10.1007/s10904-023-02833-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10904-023-02833-3

Keywords

Search

Navigation