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Design, Synthesis, Structural Investigation and Photo Induced Biological Investigations of Co(II), Ni(II) and Cu(II) Complexes Derived from N,O Donor Schiff Bases

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Abstract

A series of chelated metal complexes, [Co(LI)2] (1), [Ni(LI)2] (2), [Cu(LI)2] (3) [Co(LII)2] (4), [Ni(LII)2] (5) and [Cu(LII)2] (6) were designed and synthesized from newly synthesized Schiff bases, LI = 2-((E)-(5-(4-fluorophenyl)isoxazol-3-ylimino)methyl)-5-methylphenol and LII = 2-((E)-(5-(4-fluorophenyl)isoxazol-3-ylimino)methyl)-4-chlorophenol. The synthesized compounds were characterized by elemental analysis, nuclear magnetic resonance spectroscopy (NMR), electronic spectroscopy (UV–Vis), infrared spectroscopy (FT-IR), magnetic susceptibility (µeff), electron spin resonance spectroscopy (ESR), Thermogravimetric analysis (TGA), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), and powder X-ray diffraction analysis (P-XRD). The spectral investigations have been clearly suggested 1:2 (metal: ligand) stoichiometric complexes with square planar geometrical arrangement around the metal ion. The thermal gravimmetric analysis (TGA) of these complexes indicates greater thermal stability and various steps involved in thermal decomposition of metal complexes. The binding ability between these metal complexes and calf thymus DNA (CT-DNA) was investigated by UV–Vis, fluorescence spectroscopy and viscometric experiments, which disclosed that, the complexes interacted to CT-DNA via an intercalation binding mode. The cleavage property of metal complexes against pBR322 DNA has been explored by gel electrophoresis technique mediated by UV-illumination and H2O2, showed momentous cleavage activity. Antioxidant activity of all complexes was determined by DPPH free radical scavenging experiment and showed prominent antioxidant activity. Further, the antibacterial and antifungal activities of all compounds were screened against bacterial and fungal strains via in-vitro disc diffusion method. These studies revealed that the complexes showed comparatively more antimicrobial activity than free ligands against tested microbial strains.

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The datasets generated during and/or analysed during the current study were included in the manuscripts butany additional data needed are will be available from the corresponding author on reasonable request.

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Acknowledgements

The authors are acknowledged to the Head, Department of Chemistry, University College of Science and Director-CFRD, Osmania University, Hyderabad for providing laboratory facilities and spectral analysis. We are conveying sincere thanks to the Head, SAIF, IIT Bombay for analyzing the ESR spectral data.

Funding

DST − SERB (SB/EMEQ-141/2014), UGC − UPE (FAR) (002/OU/UPE/FAR/CO/2013), OU-DST-PURSE-II (C-DST-PURSE-II/9/2017) and DST − INSPIRE (DST/INSPIRE Fellowship/2014/167), New Delhi, India for providing financial assistance.

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Authors and Affiliations

  1. Department of Chemistry, Osmania University, Hyderabad, Telangana, 500007, India

    Gali Ramesh, Sreenu Daravath, K. Jagadesh Babu, Ravinder Dharavath, Dasari Ayodhya &  Shivaraj

  2. Department of Chemistry, Kakathiya Govt.College, Hanmakonda, Warangal (Dist), Telangana, 506001, India

    K. Jagadesh Babu

  3. Department of Chemistry, SRT Campus, Badshahitaul HNB Garhwal University, Tehri Garhwal, Uttarakhand, 249199, India

    Ravinder Dharavath

  4. Department of Applied Sciences and Humanities, Purnea College of Engineering (PCE), Bihar Engineering University Patna, DSTTE, Patna, Purnea, 854303, India

    Amit Ranjan

  5. Chemical Group, Intellectual Property India, Patent Office, Chennai, Tamil Nadu, 600032, India

    Dasari Ayodhya

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  1. Gali Ramesh
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Ramesh, G., Daravath, S., Babu, K.J. et al. Design, Synthesis, Structural Investigation and Photo Induced Biological Investigations of Co(II), Ni(II) and Cu(II) Complexes Derived from N,O Donor Schiff Bases. J Fluoresc (2024). https://doi.org/10.1007/s10895-024-03657-1

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