Abstract
Two new metal-organic compounds, namely [Cu(CrO4)(4,4’-bipy)(H2O)]·n(H2O) (1) together with [Mn(Cr2O7)(bpp)2]n (2) (4,4’-bipy is 4,4’-bipyridine and bpp is 1,3-bis(4-pyridyl)propane), were hydrothermally generated, which were characterized structurally through a series of characterization techniques. Moreover, compounds 1 and 2 have 2.95 eV and 3.02 eV of narrow optical band gap values, and possess outstanding photocatalytic effects for the methylene blue degradation under irradiation of visible light. The application of above compounds in the ophthalmic local anesthesia was examined and the specific mechanism was tested. First of all, the acetylcholine content in the synaptic cleft was measured with enzyme linked immunosorbent assay (ELISA) assay after treated with the CPs. The acetylcholine receptor relative expression on nerve cells was subsequently measured via real time reverse transcription-polymerase chain reaction (RT-PCR) under the treatment of compounds. In the end, the complexes’ toxicity was evaluated by Cell Counting Kit-8 (CCK-8) detection.
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Selected bond lengths (Å) and angles (°) for compounds 1–2 (Table S1); The hydrogen-bond parameters for compound 1 (Table S2); The PXRD patterns (a) for 1 and (b) for 2 (Fig S1); Diffuse reflectance spectra of Kubelka–Munk function versus energy for compounds 1 and 2 (Fig S2); the information could be found in the supporting information file.
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Xue-Song Gao synthesized and characterized the compounds; Rui-Qiang Sun performed the activity assay experiments.
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BALB/c mice (4–5 weeks, 20-22 g) were used for PD animal model construction. Ethics Committee approval was obtained from the Institutional Ethics Committee of Model Animal Reach Center of Tianjin Eye Hospital to the commencement of the study.
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Gao, XS., Sun, RQ. Two new photoactive metal-organic compounds for degradation of methylene blue and treatment in ophthalmic local anesthesia. J Fluoresc 32, 1125–1133 (2022). https://doi.org/10.1007/s10895-022-02911-8
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DOI: https://doi.org/10.1007/s10895-022-02911-8