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An Imidazo[1,5-α]Pyridine-Based Fluorometric Chemodosimeter for the Highly Selective Detection of Hypochlorite in Aqueous Media

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Abstract

A new fluorometric chemodosimeter 2-amino-3-(((E)-3-(1-phenylimidazo[1,5-α]pyridin-3-yl)benzylidene)amino)maleonitrile (BPI-MAL) has been designed and synthesized for sensing hypochlorite. BPI-MAL showed a selective turn-on fluorescence for ClO− through hypochlorite-promoted de-diaminomaleonitrile reaction. It also could detect ClO− in the presence of various competitive anions including reactive oxygen species. Interestingly, sensor BPI-MAL was successfully applied as a fluorescent test kit for ClO− determination. The sensing property and mechanism of BPI-MAL toward ClO− were studied by fluorescence and UV-vis spectroscopy, NMR titration and DFT calculations.

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Acknowledgements

National Research Foundation of Korea and Korea Environment Industry & Technology Institute (NRF-2018R1A2B6001686 and KEITI-2016001970001) kindly supported this work.

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  1. Department of Fine Chemistry, Seoul National University of Science and Technology, Seoul, 129-743, South Korea

    Suh Mi Hwang, Dongju Yun & Cheal Kim

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  1. Suh Mi Hwang
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  2. Dongju Yun
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Correspondence to Cheal Kim.

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Hwang, S.M., Yun, D. & Kim, C. An Imidazo[1,5-α]Pyridine-Based Fluorometric Chemodosimeter for the Highly Selective Detection of Hypochlorite in Aqueous Media. J Fluoresc 29, 451–459 (2019). https://doi.org/10.1007/s10895-019-02355-7

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