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In Vivo Non-toxicity of Gold Nanoparticles on Wistar Rats

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Abstract

A comparative toxicity studies were conducted with biologically and chemically synthesized gold nanoparticles (AuNPs). Biomolecules such as propanoic acid 2-(3-acetoxy-4,4,14-trimethylandrost-8-en-17-yl) (PAT) and proanthocyanidin (PAC) were used for biologically synthesized AuNPs and sodium citrate was used for chemically synthesized AuNPs. These synthesized AuNPs were characterized using UV–vis spectroscopy and Transmission electron microscopic. Rats were orally administered with PAT, PAC and citrate synthesized AuNPs at the dose of 5 mg/kg body weight for 28 days. Serum biochemical analysis, hematology and histochemical studies were carried out. The results indicated that the AuNPs synthesized using citrate induced toxicity whereas biomolecules (PAT and PAC) functionalized AuNPs did not show any toxicity. In conclusion, biologically mediated AuNPs can be used as effective as drug molecules or a carrier molecule for drug delivery.

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Acknowledgements

We thank to the DST-SERB, New Delhi, India for financial support and also the Adhiparasakthi College of Arts and Science, Kalavai, Vellore, Tamilnadu.

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Authors and Affiliations

  1. Centre for Ocean Research, Sathyabama Institute of Science and Technology, Chennai, 600 119, India

    Tamilselvan Selvaraj & Govindaraju Kasivelu

  2. Department of Microbiology, School of Basic Medical Sciences Taramani, University of Madras, Chennai, 600 113, India

    Ashokkumar Thirunavukkarasu

  3. Department of Pharmaceutics, Sri Venkateshwara College of Pharmacy, Chittoor, Andhra Pradesh, 517127, India

    Soniya Murali Rathnavelu

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  1. Tamilselvan Selvaraj
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  2. Ashokkumar Thirunavukkarasu
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Correspondence to Tamilselvan Selvaraj.

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Selvaraj, T., Thirunavukkarasu, A., Rathnavelu, S.M. et al. In Vivo Non-toxicity of Gold Nanoparticles on Wistar Rats. J Clust Sci 30, 513–519 (2019). https://doi.org/10.1007/s10876-019-01514-x

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  • DOI: https://doi.org/10.1007/s10876-019-01514-x

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