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Hydroxyapatite-chitosan biocomposites synthesized in the simulated body fluid and their drug loading studies

  • Biomaterials Synthesis and Characterization
  • Original Research
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Abstract

Hydroxyapatite (HAp) is a bioceramic applied in the biomedical areas, such as matrices for drug release control. Chitosan (CTS), a natural polymer, is another material has been widely investigated for its potential use in the drug delivery systems. In this study, the composites of HAp-CTS are produced in order to investigate their drug loading and release studies. First of all, HAp-CTS composites are produced in the presence of simulated body fluid (SBF). Analysis confirmed the structure of HAp-CTS composites. Secondly, composites are encapsulated with 5-Fluorouracil (5-FU). The weight ratio of CTS is varied to realize its effect on drug loading of 5-Fluorouracil, a cancer drug, for the ratios of 1:1, 1:2 and 1:4 of HAp-CTS. The weight ratio giving the greatest drug load efficiency is selected for the last step of the study. Crosslinking agent, glutaraldehyde, are changed from 0 to 5% on the selected sample, then, drug loading is examined again in various environment owing different pH. Furthermore, drug release studies are conducted. To understand the structure and morphology of the samples, XRD, FTIR, SEM and Uv-Spectrum are applied. It is observed that weight ratio of polymer and crosslinking agent can be manipulated to adjust drug loading. Release kinetics are shown the Fickian diffusion. This new produced material can be applicable for drug delivery.

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Abbreviations

d:

Diameter of particles μ

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Acknowledgements

Authors would like to show appreciation to Scientific Research Project Association of Istanbul Technical University for the foundation of this project.

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Authors and Affiliations

  1. Chemical Engineering Department, Istanbul Technical University, ITU Ayazaga Kampusu, Maslak, Istanbul, 34469, Turkey

    Tugba Basargan, Nalan Erdol-Aydin & Gulhayat Nasun-Saygili

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  1. Tugba Basargan
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  2. Nalan Erdol-Aydin
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Correspondence to Tugba Basargan.

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Basargan, T., Erdol-Aydin, N. & Nasun-Saygili, G. Hydroxyapatite-chitosan biocomposites synthesized in the simulated body fluid and their drug loading studies. J Mater Sci: Mater Med 28, 180 (2017). https://doi.org/10.1007/s10856-017-5961-0

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