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A review of preparation methods, friction and wear, corrosion, and biocompatibility of biomedical high-entropy alloys

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Abstract

In recent decades, biomedical materials have received increasing attention and are widely used in medical applications, such as implantable prostheses, tissue repair, and regeneration, to advance patient care. As implants continue to be applied in clinical settings, the design requirements for new biocompatible alloys also increase. Therefore, developing new materials with high strength, low modulus, and good biocompatibility is a continuous demand in the field of surgical implants. By breaking the classical alloy design concept, high-entropy alloys (HEAs) have a unique lattice structure, which is a solid solution randomly arranged with multiple elements. The special locally disordered chemical environment is expected to make the alloy has excellent yield strength, wear resistance, corrosion resistance, and biocompatibility. Hence, this review summarizes the research on HEAs in biomedical applications, mainly focusing on their preparation methods, wear resistance, corrosion resistance, as well as in vivo and in vitro implantation. It aims to provide valuable reference for material researchers in the application research of biomedical materials.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 12162023) and the Key Talent Projects of Gansu Province and Gansu Basic Research Innovation Group Project.

Funding

The funding was provided by the National Natural Science Foundation of China, 12162023, Dexue Liu, the Key Talent Projects of Gansu Province, Gansu Basic Research Innovation Group Project.

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Authors and Affiliations

  1. School of Materials Science and Engineering, Lanzhou University of Technology, Langongping Road 287, Lanzhou City, Gansu Province, 730050, People’s Republic of China

    Dandan Zhu, Shiwen Hu, Yongfan Fu, Ning Zhao & Dexue Liu

  2. State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals, Lanzhou University of Technology, Lanzhou, 730050, People’s Republic of China

    Dandan Zhu, Shiwen Hu, Yongfan Fu, Ning Zhao & Dexue Liu

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  1. Dandan Zhu
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  2. Shiwen Hu
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  4. Ning Zhao
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DZ took part in writing—original draft, methodology, writing—review and editing, investigation, and formal analysis. Sw H involved in writing—review and editing, investigation, and resources. YF took part in data curation. NZ involved in data curation. DL took part in supervision and visualization.

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Correspondence to Dexue Liu.

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Zhu, D., Hu, S., Fu, Y. et al. A review of preparation methods, friction and wear, corrosion, and biocompatibility of biomedical high-entropy alloys. J Mater Sci 59, 1153–1183 (2024). https://doi.org/10.1007/s10853-023-09314-5

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