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A study of a biodegradable braided Mg stent for biliary reconstruction

  • Materials for life sciences
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Abstract

Aiming at deficiencies in non-degradable stents for benign common bile duct obstruction, the magnesium (Mg)-based braided stents were developed with one monofilament as a pilot research in this paper. We designed stents with the different monofilament diameter, braided-pin number and surface treatment systematically to study the mechanical and degradation behaviors. The results suggest the fluorinated Mg stents and them with polycaprolactone (PCL) coating can achieve the compression force of 3.35–11.07 N and 11.09–24.08 N, and even maintain 3.10–10.43 N for 3 days immersion and 3.11–9.37 N for 20 days immersion respectively. PCL coating on monofilament can provide significantly better compression force and corrosion resistance. By comparison with the stent in clinic, these Mg stents are expected to meet the demand of the radial compression force and implantation time. Furthermore, the degradation occurs at the ends preferentially for all stents, but for stents without PCL coating, the intersections of wire-mesh are also the area easily corroded. Additionally, the result of the compression test indicates the radial compression force is improved with the increase of monofilament diameter and pins number, but the recovery capability decreases slightly.

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Abbreviations

CBD:

Common bile duct

FDA:

Food and Drug Administration

PCL:

Polycaprolactone

F c :

Radial compression force

E recovery :

Elastic recovery ratio

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Acknowledgements

This work was supported by the National Key Research and Development Program of China (2016YFC1102402), the National Natural Science Foundation of China (51971062) and the Science and Technology Project of Jiangsu Province (BE2019679).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Southeast University, Jiangning, Nanjing, 211189, Jiangsu, China

    Yue Zhang, Kaiyuan Chen, Yi Shao, Chenglin Chu, Feng Xue & Jing Bai

  2. Jiangsu Key Laboratory for Advanced Metallic Materials, Jiangning, Nanjing, 211189, Jiangsu, China

    Yue Zhang, Kaiyuan Chen, Yi Shao, Chenglin Chu, Feng Xue & Jing Bai

  3. College of Mechanics and Materials, Hohai University, Jiangning, Nanjing, 211100, China

    Huan Liu

  4. Institute of Biomedical Devices (Suzhou), Southeast University, Suzhou, 215163, Jiangsu, China

    Yi Shao & Jing Bai

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  1. Yue Zhang
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Correspondence to Jing Bai.

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Zhang, Y., Chen, K., Liu, H. et al. A study of a biodegradable braided Mg stent for biliary reconstruction. J Mater Sci 55, 17170–17182 (2020). https://doi.org/10.1007/s10853-020-05289-9

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  • DOI: https://doi.org/10.1007/s10853-020-05289-9

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