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Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study

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Abstract

The current study investigates the feasibility of using a biodegradable polymeric stent in common bile duct (CBD) repair and reconstruction. Here, poly(l-lactide-co-glycolide) (PLGA, molar ratio LA/GA = 80/20) was processed into a circular tube- and dumbbell-shaped specimens to determine the in vitro degradation behavior in bile. The morphology, weight loss, and molecular weight changes were then investigated in conjunction with evaluations of the mechanical properties of the specimen. Circular tube-shaped PLGA stents with X-ray opacity were subsequently used in common bile duct exploration (CBDE) and primary suturing in canine models. Next, X-ray images of CBD stents in vivo were compared and levels of serum liver enzymes and a histological analysis were conducted after stent transplantation. The results showed that the PLGA stents exhibited the required biomedical properties and spontaneously disappeared from CBDs in 4–5 weeks. The degradation period and function match the requirements in repair and reconstruction of CBDs to support the duct, guide bile drainage, and reduce T-tube-related complications.

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Acknowledgements

The authors thank Ms. Qizhi Liang & Shuhua Sun for preparing polymer materials and stents. Financial support was provided by the National Natural Science Foundation of China (Project No. 20274048 and 50373043), and by the Chinese Academy of Sciences (Project No. KJCX2-SW-H07). We also acknowledge the Program for New Century Excellent Talents in University (Project No. NCET-06-0320), and the Cultivation Fund of the Scientific and Technical Innovation Project of Northeast Normal University (Project No. NENU-STB07008).

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Authors and Affiliations

  1. National Engineering Laboratory for Druggable Gene and Protein Screening, Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, Changchun, 130024, China

    Xiaoyi Xu & Yuxin Li

  2. Department of General Surgery, First Hospital, Jilin University, Changchun, 130021, China

    Tongjun Liu, Shaohui Liu, Kai Zhang & Zhen Shen

  3. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Xiabin Jing

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  1. Xiaoyi Xu
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Correspondence to Xiabin Jing.

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Xu, X., Liu, T., Liu, S. et al. Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study. J Mater Sci: Mater Med 20, 1167–1173 (2009). https://doi.org/10.1007/s10856-008-3672-2

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  • DOI: https://doi.org/10.1007/s10856-008-3672-2

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