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A three-dimensional porous hydroxyapatite nanocomposite scaffold with shape memory effect for bone tissue engineering

  • Biomaterials
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Abstract

It is known that scaffold is a key factor in bone tissue engineering. The aim of this study was to improve the design of scaffold in order to achieve an effect of precisely matching the irregular boundaries of bone defects as well as facilitate clinical application. In this study, controllable three-dimensional porous shape memory polyurethane/nano-hydroxyapatite composite scaffolds were successfully fabricated. Detailed studies were performed to evaluate its structure, porosities, and mechanical properties, emphasizing the effect of different apertures of scaffolds on shape recovery behaviors and biological performance in vitro. Results showed its compression recovery ratios and shape recovery ratios of all scaffolds could reach more than 99 and 90%, respectively, which could let it more accurately match the irregular boundaries of bone defects. And also its cell proliferation ability was improved with the increase in the apertures. Thus, these scaffolds have potential applications for the bone tissue engineering.

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Acknowledgements

This work was supported by the Sino-foreign science and technology cooperation project of Anhui Province 2017 (1704e1002213), JSPS KAKENHI 15H01789, and 26420721.

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Authors and Affiliations

  1. Interdisciplinary Graduate School of Science and Technology, Shinshu University, 3-15-1 Tokida, Ueda, Nagano, 386-8576, Japan

    Juhong Yu

  2. Department of Mechanical Engineering and Robotics, Shinshu University, 3-15-1 Tokida, Ueda, Nagano, 386-8576, Japan

    Hong Xia & Qing-Qing Ni

  3. College of Textile and Garments, Anhui Polytechnic University, Wuhu, 241000, Anhui, China

    Qing-Qing Ni

Authors
  1. Juhong Yu
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  2. Hong Xia
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  3. Qing-Qing Ni
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Correspondence to Qing-Qing Ni.

Electronic supplementary material

Below is the link to the electronic supplementary material.

10853_2017_1807_MOESM1_ESM.docx

Supplementary information is about SEM images of MG-63 cultured on the four porous SMPU/nHAP composite scaffolds after 1, 3, and 5 days. (DOCX 1845 kb)

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Yu, J., Xia, H. & Ni, QQ. A three-dimensional porous hydroxyapatite nanocomposite scaffold with shape memory effect for bone tissue engineering. J Mater Sci 53, 4734–4744 (2018). https://doi.org/10.1007/s10853-017-1807-x

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  • DOI: https://doi.org/10.1007/s10853-017-1807-x

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