Skip to main content

Advertisement

SpringerLink
Log in

Summary of the ISFP congress, Brussels, 10–12 November, 2022

  • Meeting Proceedings
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

The 7th International Congress of the ISFP was held in Brussels in November 2022. Hundreds of attendees from all over the world had the rare opportunity to hear the most distinguished leaders discuss and debate the latest advances in the field. Participants were also able to attend workshops under the guidance of skilled practitioners. Numerous topics were considered, including a recap on fertility preservation approaches in cancer and benign pathologies and a section on male factor infertility. Other aspects covered were in vitro maturation and poor responders, the impact of chemotherapy on the ovary, and future perspectives. Participants had the chance to listen to a symposium on fertility preservation techniques, and finally, a keynote lecture on fertility preservation in gynecological cancers brought this prominent and highly influential event to a close.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Donnez J, Dolmans MM, Demylle D, Jadoul P, Pirard C, Squifflet J, Martinez-Madrid B, van Langendonckt A. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;364(9443):1405–10.

    Article  CAS  PubMed  Google Scholar 

  2. Shapira M, Dolmans MM, Silber S, Meirow D. Evaluation of ovarian tissue transplantation: results from three clinical centers. Fertility and Sterility. 2020 Aug;114(2):388–97.

    Article  PubMed  Google Scholar 

  3. Dolmans MM, von Wolff M, Poirot C, Diaz-Garcia C, Cacciottola L, Boissel N, Liebenthron J, Pellicer A, Donnez J, Andersen CY. Transplantation of cryopreserved ovarian tissue in a series of 285 women: a review of five leading European centers. Fertility and Sterility. 2021 May;115(5):1102–15.

    Article  CAS  PubMed  Google Scholar 

  4. Anderson RA, Wallace WH, Baird DT. Ovarian cryopreservation for fertility preservation: indications and outcomes. Reproduction. 2008 Dec;136(6):681–9.

    Article  CAS  PubMed  Google Scholar 

  5. Dolmans MM, Isaacson K, Zhang W, Gordts S, Munro MG, Stewart EA, Bourdon M, Santulli P, Donnez J. Intramural myomas more than 3-4 centimeters should be surgically removed before in vitro fertilization. Fertility and Sterility. 2021 Oct;116(4):945–58.

    Article  PubMed  Google Scholar 

  6. Zhai J, Vannuccini S, Petraglia F, Giudice LC. Adenomyosis: mechanisms and pathogenesis. Seminars in reproductive medicine. 2020 May;38(2-03):129–43.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Cobo A, Giles J, Paolelli S, Pellicer A, Remohí J, García-Velasco JA. Oocyte vitrification for fertility preservation in women with endometriosis: an observational study. Fertility and Sterility. 2020 Apr;113(4):836–44.

    Article  PubMed  Google Scholar 

  8. Cozzolino M, Tartaglia S, Pellegrini L, Troiano G, Rizzo G, Petraglia F. The effect of uterine adenomyosis on IVF outcomes: a systematic review and meta-analysis. Reproductive Sciences. 2022 Nov;29(11):3177–93.

    Article  CAS  PubMed  Google Scholar 

  9. Nirgianakis K, Kalaitzopoulos DR, Schwartz ASK, Spaanderman M, Kramer BW, Mueller MD, Mueller M. Fertility, pregnancy and neonatal outcomes of patients with adenomyosis: a systematic review and meta-analysis. Reproductive biomedicine online. 2021 Jan;42(1):185–206.

    Article  PubMed  Google Scholar 

  10. Osada H. Uterine adenomyosis and adenomyoma: the surgical approach. Fertility and Sterility. 2018 Mar;109(3):406–17.

    Article  PubMed  Google Scholar 

  11. Donnez O, Donnez J. Gonadotropin-releasing hormone antagonist (linzagolix): a new therapy for uterine adenomyosis. Fertility and Sterility. 2020 Sep;114(3):640–5.

    Article  CAS  PubMed  Google Scholar 

  12. Cobo A, Coello A, de Los Santos MJ, Giles J, Pellicer A, Remohí J, García-Velasco JA. Number needed to freeze: cumulative live birth rate after fertility preservation in women with endometriosis. Reproductive biomedicine online. 2021 Apr;42(4):725–32.

    Article  PubMed  Google Scholar 

  13. Peek R, Schleedoorn M, Smeets D, van de Zande G, Groenman F, Braat D, van der Velden J, Fleischer K. Ovarian follicles of young patients with Turner's syndrome contain normal oocytes but monosomic 45,X granulosa cells. Human Reproduction. 2019 Sep 29;34(9):1686–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Brännström M, Johannesson L, Bokström H, Kvarnström N, Mölne J, Dahm-Kähler P, Enskog A, Milenkovic M, Ekberg J, Diaz-Garcia C, Gäbel M, Hanafy A, Hagberg H, Olausson M, Nilsson L. Livebirth after uterus transplantation. Lancet. 2015 Feb 14;385(9968):607–16.

    Article  PubMed  Google Scholar 

  15. Farrell RM, Falcone T. Uterine transplant: new medical and ethical considerations. Lancet. 2015 Feb 14;385(9968):581–2.

    Article  PubMed  Google Scholar 

  16. Mölne J, Broecker V, Ekberg J, Nilsson O, Dahm-Kähler P, Brännström M. Monitoring of human uterus transplantation with cervical biopsies: a provisional scoring system for rejection. American Journal of Transplantation. 2017 Jun;17(6):1628–36.

    Article  PubMed  Google Scholar 

  17. Ayoubi JM, Carbonnel M, Racowsky C, de Ziegler D, Gargiulo A, Kvarnström N, Dahm-Kähler P, Brännström M. Evolving clinical challenges in uterus transplantation. Reproductive biomedicine online. 2022 Nov;45(5):947–60.

    Article  PubMed  Google Scholar 

  18. Goossens E, Jahnukainen K, Mitchell RT, van Pelt A, Pennings G, Rives N, Poels J, Wyns C, Lane S, Rodriguez-Wallberg KA, Rives A, Valli-Pulaski H, Steimer S, Kliesch S, Braye A, Andres MM, Medrano J, Ramos L, Kristensen SG, et al. Fertility preservation in boys: recent developments and new insights †. Human reproduction open. 2020;2020(3):hoaa016.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Tian En L, Brougham MFH, Wallace WHB, Mitchell RT. Impacts of platinum-based chemotherapy on subsequent testicular function and fertility in boys with cancer. Human reproduction update. 2020 Nov 1;26(6):874–85.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Delessard M, Saulnier J, Dumont L, Rives-Feraille A, Rives N, Rondanino C. Paradoxical risk of reduced fertility after exposure of prepubertal mice to vincristine or cyclophosphamide at low gonadotoxic doses in humans. Scientific reports. 2020 Oct 20;10(1):17859.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Baert Y, Ruetschle I, Cools W, Oehme A, Lorenz A, Marx U, Goossens E, Maschmeyer I. A multi- organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model. Human Reproduction. 2020 May 1;35(5):1029–44.

    Article  CAS  PubMed  Google Scholar 

  22. Mattawanon N, Spencer JB, Schirmer DA 3rd, Tangpricha V. Fertility preservation options in transgender people: a review. Reviews in Endocrine and Metabolic Disorders. 2018 Sep;19(3):231–42.

    Article  PubMed  Google Scholar 

  23. De Roo C, Lierman S, Tilleman K, Peynshaert K, Braeckmans K, Caanen M, Lambalk CB, Weyers S, T'Sjoen G, Cornelissen R, De Sutter P. Ovarian tissue cryopreservation in female-to-male transgender people: insights into ovarian histology and physiology after prolonged androgen treatment. Reproductive biomedicine online. 2017 Jun;34(6):557–66.

    Article  PubMed  Google Scholar 

  24. ESHRE Guideline Group on Female Fertility Preservation, Anderson RA, Amant F, Braat D, D’Angelo A, Chuva de Sousa Lopes SM, Demeestere I, Dwek S, Frith L, Lambertini M, Maslin C, Moura-Ramos M, Nogueira D, Rodriguez-Wallberg K, Vermeulen N. ESHRE guideline: female fertility preservation. Human reproduction open. 2020;2020(4):hoaa052.

    Article  Google Scholar 

  25. Segers I, Bardhi E, Mateizel I, Van Moer E, Schots R, Verheyen G, Tournaye H, De Vos M. Live births following fertility preservation using in-vitro maturation of ovarian tissue oocytes. Human Reproduction. 2020 Sep 1;35(9):2026–36.

    Article  PubMed  Google Scholar 

  26. Telfer EE, Andersen CY. In vitro growth and maturation of primordial follicles and immature oocytes. Fertility and Sterility. 2021 May;115(5):1116–25.

    Article  CAS  PubMed  Google Scholar 

  27. Nikiforov D, Junping C, Cadenas J, Shukla V, Blanshard R, Pors SE, Kristensen SG, Macklon KT, Colmorn L, Ernst E, Bay-Bjørn AM, Ghezelayagh Z, Wakimoto Y, Grøndahl ML, Hoffmann E, Andersen CY. Improving the maturation rate of human oocytes collected ex vivo during the cryopreservation of ovarian tissue. Journal of assisted reproduction and genetics. 2020 Apr;37(4):891–904.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Kristensen SG, Mamsen LS, Jeppesen JV, Bøtkjær JA, Pors SE, Borgbo T, Ernst E, Macklon KT, Andersen CY. Hallmarks of human small antral follicle development: implications for regulation of ovarian steroidogenesis and selection of the dominant follicle. Frontiers in endocrinology. 2018;8:376.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Grosbois J, Devos M, Demeestere I. Implications of nonphysiological ovarian primordial follicle activation for fertility preservation. Endocrine reviews. 2020;41(6):bnaa020.

    Article  PubMed  Google Scholar 

  30. Kawamura K, Cheng Y, Suzuki N, Deguchi M, Sato Y, Takae S, Ho CH, Kawamura N, Tamura M, Hashimoto S, Sugishita Y, Morimoto Y, Hosoi Y, Yoshioka N, Ishizuka B, Hsueh AJ. Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. Proceedings of the National Academy of Sciences. 2013 Oct 22;110(43):17474–9.

    Article  CAS  Google Scholar 

  31. Griesinger G, Fauser BCJM. Drug-free in-vitro activation of ovarian cortex; can it really activate the 'ovarian gold reserve'? Reproductive BioMedicine Online. 2020 Feb;40(2):187–9.

    Article  CAS  PubMed  Google Scholar 

  32. Dolmans MM, Cordier F, Amorim CA, Donnez J, Vander LC. In vitro activation prior to transplantation of human ovarian tissue: is it truly effective? Frontiers in endocrinology. 2019;10:520.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Cakiroglu Y, Yuceturk A, Karaosmanoglu O, Kopuk SY, Korun ZEU, Herlihy N, Scott RT, Tiras B, Seli E. Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Aging. 2022 Mar 22;14(6):2513–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Herraiz S, Buigues A, Díaz-García C, Romeu M, Martínez S, Gómez-Seguí I, Simón C, Hsueh AJ, Pellicer A. Fertility rescue and ovarian follicle growth promotion by bone marrow stem cell infusion. Fertility and sterility. 2018;109(5):908–918.e2.

    Article  PubMed  Google Scholar 

  35. Rodríguez-Varela C, Labarta E. Role of mitochondria transfer in infertility: a commentary. Cells. 2022 Jun 8;11(12):1867.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Shai D, Aviel-Ronen S, Spector I, Raanani H, Shapira M, Gat I, Roness H, Meirow D. Ovaries of patients recently treated with alkylating agent chemotherapy indicate the presence of acute follicle activation, elucidating its role among other proposed mechanisms of follicle loss. Fertility and sterility. 2021 May;115(5):1239–49.

    Article  CAS  PubMed  Google Scholar 

  37. Kalich-Philosoph L, Roness H, Carmely A, Fishel-Bartal M, Ligumsky H, Paglin S, Wolf I, Kanety H, Sredni B, Meirow D. Cyclophosphamide triggers follicle activation and "burnout"; AS101 prevents follicle loss and preserves fertility. Science translational medicine. 2013;5(185):185ra62.

    Article  PubMed  Google Scholar 

  38. Poirot C, Fortin A, Lacorte JM, Akakpo JP, Genestie C, Vernant JP, Brice P, Morice P, Leblanc T, Gabarre J, Delmer A, Badachi Y, Drouineaud V, Gouy S, Chalas C, Egels S, Dhédin N, Touraine P, Dommergues M, et al. Boissel N; CAROLéLISA Cooperative Group. Impact of cancer chemotherapy before ovarian cortex cryopreservation on ovarian tissue transplantation. Human Reproduction. 2019 Jun 4;34(6):1083–94.

    Article  CAS  PubMed  Google Scholar 

  39. Poirot C, Fortin A, Dhédin N, Brice P, Socié G, Lacorte JM, Akakpo JP, Genestie C, Vernant JP, Leblanc T, Gabarre J, Delmer A, Badachi Y, Drouineaud V, Chalas C, Egels S, Touraine P, Dommergues M, Lebègue G, et al. Post-transplant outcome of ovarian tissue cryopreserved after chemotherapy in hematologic malignancies. Haematologica. 2019 Aug;104(8):e360–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Meirow D, Levron J, Eldar-Geva T, Hardan I, Fridman E, Zalel Y, Schiff E, Dor J. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. New England Journal of Medicine. 2005 Jul 21;353(3):318–21.

    Article  CAS  PubMed  Google Scholar 

  41. Demeestere I, Racape J, Dechene J, Dupuis J, Morschhauser F, De Wilde V, Lazarovici J, Ghesquieres H, Touati M, Sibon D, Alexis M, Gac AC, Moatti H, Virelizier E, Maisonneuve H, Pranger D, Houot R, Fornecker LM, Tempescul A, et al. Gonadal function recovery in patients with advanced hodgkin lymphoma treated with a PET-adapted regimen: prospective analysis of a randomized phase III trial (AHL2011). Journal of Clinical Oncology. 2021 Oct 10;39(29):3251–60.

    Article  CAS  PubMed  Google Scholar 

  42. Lambertini M, HCF M, RCF L, Loibl S, Munster P, Bruzzone M, Boni L, Unger JM, Anderson RA, Mehta K, Minton S, Poggio F, Albain KS, DJA A, Gerber B, Cripps A, Bertelli G, Seiler S, Ceppi M, et al. Gonadotropin-releasing hormone agonists during chemotherapy for preservation of ovarian function and fertility in premenopausal patients with early breast cancer: a systematic review and meta-analysis of individual patient-level data. Journal of clinical oncology. 2018;36(19):1981–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Gonfloni S, Di Tella L, Caldarola S, Cannata SM, Klinger FG, Di Bartolomeo C, Mattei M, Candi E, De Felici M, Melino G, Cesareni G. Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death. Nature medicine. 2009 Oct;15(10):1179–85.

    Article  CAS  PubMed  Google Scholar 

  44. Goldman KN, Chenette D, Arju R, Duncan FE, Keefe DL, Grifo JA, Schneider RJ. mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy. Proceedings of the National Academy of Sciences. 2017 Mar 21;114(12):3186–91.

    Article  CAS  Google Scholar 

  45. Alexandri C, Daniel A, Bruylants G, Demeestere I. The role of microRNAs in ovarian function and the transition toward novel therapeutic strategies in fertility preservation: from bench to future clinical application. Human reproduction update. 2020 Feb 28;26(2):174–96.

    Article  CAS  PubMed  Google Scholar 

  46. Youssef MAFM, Van der Veen F, Al-Inany HG, Mochtar MH, Griesinger G, Nagi Mohesen M, Aboulfoutouh I, van Wely M. Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in antagonist-assisted reproductive technology (review). Cochrane Database of Systematic. 2014;31(10):CD008046.

    Google Scholar 

  47. Walker Z, Lanes A, Ginsburg E. Oocyte cryopreservation review: outcomes of medical oocyte cryopreservation and planned oocyte cryopreservation. Reproductive Biology and Endocrinology. 2022 Jan 7;20(1):10.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Gil-Arribas E, Blockeel C, Pennings G, Nekkebroeck J, Velasco JAG, Serna J, De Vos M. Oocyte vitrification for elective fertility preservation: a SWOT analysis. Reproductive biomedicine online. 2022 Jun;44(6):1005–14.

    Article  PubMed  Google Scholar 

  49. Donnez J, Dolmans MM. Natural hormone replacement therapy with a functioning ovary after the menopause: dream or reality? Reproductive biomedicine online. 2018 Sep;37(3):359–66.

    Article  PubMed  Google Scholar 

  50. Cacciottola L, Nguyen TYT, Amorim CA, Donnez J, Dolmans MM. Modulating hypoxia and oxidative stress in human xenografts using adipose tissue-derived stem cells. F&S Science. 2021 May;2(2):141–52.

    Article  Google Scholar 

  51. Cacciottola L, Courtoy GE, Nguyen TYT, Hossay C, Donnez J, Dolmans MM. Adipose tissue- derived stem cells protect the primordial follicle pool from both direct follicle death and abnormal activation after ovarian tissue transplantation. Journal of Assisted Reproduction and Genetics. 2021 Jan;38(1):151–61.

    Article  PubMed  Google Scholar 

  52. McLaughlin M, Albertini DF, Wallace WHB, Anderson RA, Telfer EE. Metaphase II oocytes from human unilaminar follicles grown in a multi-step culture system. Molecular Human Reproduction. 2018 Mar 1;24(3):135–42.

    Article  CAS  PubMed  Google Scholar 

  53. Telfer EE, McLaughlin M, Ding C, Thong KJ. A two-step serum-free culture system supports development of human oocytes from primordial follicles in the presence of activin. Human Reproduction. 2008 May;23(5):1151–8.

    Article  CAS  PubMed  Google Scholar 

  54. Amargant F, Manuel SL, Tu Q, Parkes WS, Rivas F, Zhou LT, Rowley JE, Villanueva CE, Hornick JE, Shekhawat GS, Wei JJ, Pavone ME, Hall AR, Pritchard MT, Duncan FE. Ovarian stiffness increases with age in the mammalian ovary and depends on collagen and hyaluronan matrices. Aging Cell. 2020 Nov;19(11):e13259.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Morice P, Maulard A, Scherier S, Sanson C, Zarokian J, Zaccarini F, Espenel S, Pautier P, Leary A, Genestie C, Chargari C, Grynberg M, Gouy S. Oncologic results of fertility sparing surgery of cervical cancer: an updated systematic review. Gynecologic Oncology. 2022 Apr;165(1):169–83.

    Article  CAS  PubMed  Google Scholar 

  56. Canlorbe G, Chabbert-Buffet N, Uzan C. Fertility-sparing surgery for ovarian cancer. Journal of Clinical Medicine. 2021 Sep 18;10(18):4235.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Colombo N, Sessa C, du Bois A, Ledermann J, McCluggage WG, McNeish I, Morice P, Pignata S, Ray-Coquard I, Vergote I, Baert T, Belaroussi I, Dashora A, Olbrecht S, Planchamp F, Querleu D. ESMO-ESGO Ovarian Cancer Consensus Conference Working Group. ESMO-ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease†. Annals of Oncology. 2019 May 1;30(5):672–705.

    Article  CAS  PubMed  Google Scholar 

  58. Ray-Coquard I, Morice P, Lorusso D, Prat J, Oaknin A, Pautier P, Colombo N, ESMO Guidelines Committee. Non-epithelial ovarian cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 2018;29(Suppl 4):iv1–iv18.

    Article  CAS  PubMed  Google Scholar 

  59. von Wolff M, Nawroth F, Schüring A. Turner syndrome. In: Fertility preservation in oncological and non-oncological diseases. 1st ed. Switzerland: Springer Nature Switzerland AG; 2020.

    Chapter  Google Scholar 

Download references

Acknowledgments

The authors thank Jacques Donnez, M.D., Ph.D, and Luciana Cacciottola M.D., Ph.D., for their helpful suggestions and Mira Hryniuk, B.A., for reviewing the English language of the article.

Funding

This paper was supported by grants from the Fonds National de la Recherche Scientifique de Belgique (grant FNRS TLV-7.4531.22. awarded to L.H. and grant 5/4/150/5 awarded to M.M.D.).

Author information

Authors and Affiliations

  1. Gynecology Research Unit, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium

    Lara Houeis & Marie-Madeleine Dolmans

  2. Department of Gynecology, Cliniques Universitaires Saint-Luc, Brussels, Belgium

    Marie-Madeleine Dolmans

Authors
  1. Lara Houeis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marie-Madeleine Dolmans
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marie-Madeleine Dolmans.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Houeis, L., Dolmans, MM. Summary of the ISFP congress, Brussels, 10–12 November, 2022. J Assist Reprod Genet 40, 433–442 (2023). https://doi.org/10.1007/s10815-023-02720-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10815-023-02720-3

Keywords

Search

Navigation