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Male chromosomal polymorphisms reduce cumulative live birth rate for IVF couples

  • Assisted Reproduction Technologies
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

Chromosomal polymorphisms are associated with infertility, but their effects on assisted reproductive outcomes are still quite conflicting, especially after IVF treatment. This study evaluated the role of chromosomal polymorphisms of different genders in IVF pregnancy outcomes.

Methods

Four hundred and twenty-five infertile couples undergoing IVF treatment were divided into three groups: 214 couples with normal chromosomes (group A, control group), 86 couples with female polymorphisms (group B), and 125 couples with male polymorphisms (group C). The pregnancy outcomes after the first and cumulative transfer cycles were analyzed, and the main outcome measures were live birth rate (LBR) after the first transfer cycle and cumulative LBR after a complete IVF cycle.

Results

Comparison of pregnancy outcomes after the first transfer cycle within group A, group B, and group C demonstrated a similar LBR as well as other rates of implantation, clinical pregnancy, early miscarriage, and ongoing pregnancy (P > 0.05). However, the analysis of cumulative pregnancy outcomes indicated that compared with group A, group C had a significantly lower LBR per cycle (80.4 vs 68.00%), for a rate ratio of 1.182 (95% CI 1.030 to 1.356, P = 0.01) and a significantly higher cumulative early miscarriage rate (EMR) among clinical pregnancies (7.2 vs 14.7%), for a rate ratio of 0.489 (95% CI 0.248 to 0.963, P = 0.035).

Conclusion

Couples with chromosomal polymorphisms in only male partners have poor pregnancy outcomes after IVF treatment manifesting as high cumulative EMR and low LBR after a complete cycle.

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Acknowledgements

The authors would like to thank Keliang Wu and other personnel in the IVF laboratory for their help in precious participation in laboratory procedures.

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Authors and Affiliations

  1. Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong Provincial Key Laboratory of Reproductive Medicine, Jingliu Road 157, Jinan, 250021, China

    Tianxiang Ni, Jing Li, Hong Chen, Yuan Gao, Xuan Gao, Junhao Yan & Zi-Jiang Chen

  2. National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, 250021, China

    Yuan Gao, Xuan Gao, Junhao Yan & Zi-Jiang Chen

  3. The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, 250021, China

    Yuan Gao, Xuan Gao, Junhao Yan & Zi-Jiang Chen

  4. Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

    Zi-Jiang Chen

  5. Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China

    Zi-Jiang Chen

Authors
  1. Tianxiang Ni
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  2. Jing Li
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  3. Hong Chen
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  4. Yuan Gao
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  5. Xuan Gao
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  6. Junhao Yan
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  7. Zi-Jiang Chen
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Corresponding author

Correspondence to Junhao Yan.

Ethics declarations

All procedures performed in our study involving human participants were in accordance with the ethical standards of the institutional review board of reproductive medicine and with the 1964 Helsinki Declaration and its later amendments. For this type of study, formal consent is not required. Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare that they have no conflict of interest.

Funding

This work was supported by the National Basic Research Program of China (973 Program) (2012CB944700) and Science Research Foundation Item of No-earnings Health Vocation (201402004).

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Ni, T., Li, J., Chen, H. et al. Male chromosomal polymorphisms reduce cumulative live birth rate for IVF couples. J Assist Reprod Genet 34, 1017–1025 (2017). https://doi.org/10.1007/s10815-017-0951-1

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  • DOI: https://doi.org/10.1007/s10815-017-0951-1

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