Skip to main content

Advertisement

Log in

Exploiting biological activities of brown seaweed Ishige okamurae Yendo for potential industrial applications: a review

  • Published:
Journal of Applied Phycology Aims and scope Submit manuscript

Abstract

Functional products such as cosmeceuticals, functional foods, and nutraceuticals with natural ingredients have more market demand than their synthetic counterparts due to the lower side effects and health-promoting properties associated with the natural functional ingredients. Ishige okamurae is an edible brown seaweed growing on rocks in the upper and middle intertidal zones of rough open coasts in Korea, Japan, and China. Studies carried out to isolate and evaluate the bioactive properties of crude and pure compounds from I. okamurae have shown promising results under in vitro and in vivo conditions. As a result, I. okamurae has recently gained considerable attention as a functional material in industries such as functional foods, nutraceuticals, and cosmeceuticals. However, the promising health effects associated with the extracts and pure compounds isolated from I. okamurae have not been reviewed to date. Herein, the authors review some health-promoting properties of crude and pure compounds from this seaweed, including anti-cancer, anti-oxidant, anti-inflammation, anti-HIV, anti-diabetic, anti-obesity, and anti-MMP activities. Thus, this review might serve to increase the utilization of this invaluable natural resource as an ingredient in the aforementioned industries.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  • Ahn M-J, Yoon K-D, Kim C, Min S-Y, Y-u K, Kim H, Kim J, Shin C-G, Lee C-K, Kim T, Kim S, Huh H, Kim J (2002) Inhibition of HIV-1 reverse transcriptase and HIV-1 integrase and antiviral activity of Korean seaweed extracts. J Appl Phycol 14:325–329

    Article  CAS  Google Scholar 

  • Ahn MJ, Yoon KD, Kim CY, Kim JH, Shin CG, Kim J (2006) Inhibitory activity on HIV-1 reverse transcriptase and integrase of a carmalol derivative from a brown alga, Ishige okamurae. Phytother Res 20:711–713

    Article  CAS  PubMed  Google Scholar 

  • Artan M, Li Y, Karadeniz F, Lee S-H, Kim M-M, Kim S-K (2008) Anti-HIV-1 activity of phloroglucinol derivative, 6,6′-bieckol, from Ecklonia cava. Bioorg Med Chem 16:7921–7926

    Article  CAS  PubMed  Google Scholar 

  • Augustinsson K-B (1963) Classification and comparative enzymology of the cholinesterases and methods for their determination. In: Koelle G (ed) Cholinesterases and anticholinesterase agents, Handbook of experimental pharmacology, vol 15. Springer, Berlin, pp 89–128

    Chapter  Google Scholar 

  • Bae MJ, Karadeniz F, Ahn B-N, Kong C-S (2015) Evaluation of effective MMP inhibitors from eight different brown algae in human fibrosarcoma ht1080 cells. Prev Nut Food Sci 20:153–161

    Article  Google Scholar 

  • Barre-Sinoussi F, Chermann J, Rey F, Nugeyre M, Chamaret S, Gruest J, Dauguet C, Axler-Blin C, Vezinet-Brun F, Rouzioux C, Rozenbaum W, Montagnier L (1983) Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220:868–871

    Article  CAS  PubMed  Google Scholar 

  • Bazelyansky M, Robey E, Kirsch JF (1986) Fractional diffusion-limited component of reactions catalyzed by acetylcholinesterase. Biochemistry 25:125–130

    Article  CAS  PubMed  Google Scholar 

  • Betteridge DJ (1989) Diabetes, lipoprotein metabolism and atherosclerosis. Brit Med Bull 45:285–311

    Article  CAS  PubMed  Google Scholar 

  • Birkedal-Hansen H, Moore WGI, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A, Engler JA (1993) Matrix metalloproteinases: a review. Crit Rev Oral Biol Med 4:197–250

    Article  CAS  PubMed  Google Scholar 

  • Britton G (1995) Structure and properties of carotenoids in relation to function. FASEB J 9:1551–1558

    CAS  PubMed  Google Scholar 

  • Castranova V, Ahn G, Heo S-J, Kang S-M, Kang M-C, Yang H-M, Kim D, Roh SW, Kim S-K, Jeon B-T, Park P-J, Jung W-K, Jeon Y-J (2013) Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells. Environ Toxicol Pharmacol 35:39–46

    Article  Google Scholar 

  • Cho J-Y, Gyawali YP, Ahn S-H, Khan MNA, Kong I-S, Hong Y-K (2008) A methoxylated fatty acid isolated from the brown seaweed Ishige okamurae inhibits bacterial phospholipase A2. Phytother Res 22:1070–1074

    Article  CAS  PubMed  Google Scholar 

  • Cornelius P, Mac Dougald OA, Lane MD (1994) Regulation of adipocyte development. Annu Rev Nutr 14:99–129

    Article  CAS  PubMed  Google Scholar 

  • Cragg GM, Boyd M (1996) Drug discovery and development at the national cancer institute: the role of natural products of plant origin. In: Balick MJ, Elesabetsky E, Laird SA (eds) Medicinal plant resources of the tropical forest. Columbia University Press, NY, pp 101–136

    Google Scholar 

  • De Clercq E (2009) Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. Int J Antimicrob Agents 33:307–320

    Article  PubMed  Google Scholar 

  • Dembitsky VM, Maoka T (2007) Allenic and cumulenic lipids. Prog Lipid Res 46:328–375

    Article  CAS  PubMed  Google Scholar 

  • El-Mekkawy S, Meselhy MR, Nakamura N, Tezuka Y, Hattori M, Kakiuchi N, Shimotohno K, Kawahata T, Otake T (1998) Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry 49:1651–1657

    Article  CAS  PubMed  Google Scholar 

  • FAO (2014) Aquaculture production 1950–2012 (FishstatJ). In: FAO fisheries and aquaculture department [online or CD-ROM]. Rome. Updated 2014. http://www.fao.org/fishery/statistics/software/fishstatj/en

  • Fernando IPS, Kim M, Son K-T, Jeong Y, Jeon Y-J (2016) Antioxidant activity of marine algal polyphenolic compounds: a mechanistic approach. J Med Food 19:615–628

    Article  PubMed  Google Scholar 

  • Formiguera X, Cantón A (2004) Obesity: epidemiology and clinical aspects. Best Pract Res Clin Gastroenterol 18:1125–1146

    Article  PubMed  Google Scholar 

  • Furuyashiki T, Nagayasu H, Aoki Y, Bessho H, Hashimoto T, Kanazawa K, Ashida H (2004) Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARγ2 and C/EBPα in 3T3-L1 cells. Biosci Biotechnol Biochem 68:2353–2359

    Article  CAS  PubMed  Google Scholar 

  • Green JA, Smith GM, Buchta R, Lee R, Ho KY, Rajkovic IA, Scott KF (1991) Circulating phospholipase a 2 activity associated with sepsis and septic shock is indistinguishable from that associated with rheumatoid arthritis. Inflammation 15:355–367

    Article  CAS  PubMed  Google Scholar 

  • Greig NH, Utsuki T, Yu Q-s, Zhu X, Holloway HW, Perry T, Lee B, Ingram DK, Lahiri DK (2001) A new therapeutic target in Alzheimer’s disease treatment: attention to butyrylcholinesterase. Curr Med Res Opin 17:159–165

    Article  CAS  PubMed  Google Scholar 

  • Gupta S, Abu-Ghannam N (2011) Bioactive potential and possible health effects of edible brown seaweeds. Trends Food Sci Technol 22:315–326

    Article  CAS  Google Scholar 

  • Hammoud T, Tanguay J-F, Bourassa MG (2000) Management of coronary artery disease: therapeutic options in patients with diabetes. J Amer Coll Cardiol 36:355–365

    Article  CAS  Google Scholar 

  • Handique JG, Baruah JB (2002) Polyphenolic compounds: an overview. React Funct Polym 52:163–188

    Article  CAS  Google Scholar 

  • Heo S-J, Jeon Y-J (2008) Radical scavenging capacity and cytoprotective effect of enzymatic digests of Ishige okamurae. J Appl Phycol 20:1087–1095

    Article  Google Scholar 

  • Heo S-J, Jeon Y-J (2009) Evaluation of diphlorethohydroxycarmalol isolated from Ishige okamurae for radical scavenging activity and its protective effect against H2O2-induced cell damage. Process Biochem 44:12–418

    Article  Google Scholar 

  • Heo S-J, Hwang J-Y, Choi J-I, Han J-S, Kim H-J, Jeon Y-J (2009) Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent α-glucosidase and α-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice. Eur J Pharmacol 615:252–256

    Article  CAS  PubMed  Google Scholar 

  • Heo S-J, Hwang J-Y, Choi J-I, Lee S-H, Park P-J, Kang D-H, Oh C, Kim D-W, Han J-S, Jeon Y-J (2010) Protective effect of diphlorethohydroxycarmalol isolated from Ishige okamurae against high glucose-induced-oxidative stress in human umbilical vein endothelial cells. Food Chem Toxicol 48:1448–1454

    Article  CAS  PubMed  Google Scholar 

  • Heo S-J, Cha S-H, Kim K-N, Lee S-H, Ahn G, Kang D-H, Oh C, Choi Y-U, Affan A, Kim D, Jeon Y-J (2012) Neuroprotective effect of phlorotannin isolated from Ishige okamurae against H2O2-induced oxidative stress in murine hippocampal neuronal cells, HT22. Appl Biochem Biotechnol 166:1520–1532

    Article  CAS  PubMed  Google Scholar 

  • Herath KHINM, Bing SJ, Cho J, Kim A, Shin S, Kim G-O, Lee J-C, Jee Y (2016) Anti-inflammatory activities of Dangyuja (Citrus grandis Osbeck) in concanavalin a stimulated murine splenocytes and 12-O-tetradecanoylphorbol-13-acetate-induced murine skin edema. Biomed Pharmacother 83:1353–1364

    Article  PubMed  Google Scholar 

  • Hosakawa M, Bhaskar N, Sashima T, Miyashita K (2006) Fucoxanthin as a bioactive and nutritionally beneficial marine carotenoid: a review. Carotenoid Sci 10:15–28

    Google Scholar 

  • Kang M-C, Lee S-H, Lee W-W, Kang N, Kim E-A, Kim SY, Lee DH, Kim D, Jeon Y-J (2014) Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model. J Funct Foods 11:304–312

    Article  CAS  Google Scholar 

  • Karp CL, Flick LM, Park KW, Softic S, Greer TM, Keledjian R, Yang R, Uddin J, Guggino WB, Atabani SF, Belkaid Y, Xu Y, Whitsett JA, Accurso FJ, Wills-Karp M, Petasis NA (2004) Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway. Nat Immunol 5:388–392

    Article  CAS  PubMed  Google Scholar 

  • Karunakaran U, Park K-G (2013) A systematic review of oxidative stress and safety of antioxidants in diabetes: focus on islets and their defense. Diabetes Metab J 37:106–112

    Article  PubMed  PubMed Central  Google Scholar 

  • Kashiwada Y, Wang H-K, Nagao T, Kitanaka S, Yasuda I, Fujioka T, Yamagishi T, Cosentino LM, Kozuka M, Okabe H, Ikeshiro Y, Hu C-Q, Yeh E, Lee K-H (1998) Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids. J Nat Prod 61:1090–1095

    Article  CAS  PubMed  Google Scholar 

  • Kim YA, Kong CS, Um YR, Im Lee J, Nam TJ, Seo Y (2008) Antioxidant efficacy of extracts from a variety of seaweeds in a cellular system. Ocean Sci J 43:31–37

    Article  CAS  Google Scholar 

  • Kim MM, Rajapakse N, Kim SK (2009) Anti-inflammatory effect of Ishige okamurae ethanolic extract via inhibition of NF-κB transcription factor in RAW 264.7 cells. Phytother Res 23:628–634

    Article  PubMed  Google Scholar 

  • Kim K-N, Heo S-J, Kang S-M, Ahn G, Jeon Y-J (2010a) Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway. Toxicol in Vitro 24:1648–1654

    Article  CAS  PubMed  Google Scholar 

  • Kim K-N, Heo S-J, Yoon W-J, Kang S-M, Ahn G, Yi T-H, Jeon Y-J (2010b) Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages. Eur J Pharmacol 649:369–375

    Article  CAS  PubMed  Google Scholar 

  • Kim H-H, Kim H-S, Ko J-Y, Kim C-Y, Lee J-H, Jeon Y-J (2016) A single-step isolation of useful antioxidant compounds from Ishige okamurae by using centrifugal partition chromatography. Fish Aquat Sci 19(1):22. doi:10.1186/s41240-016-0023-y

    Article  Google Scholar 

  • Ko E-Y, Yoon W-J, Lee H-W, Heo S-J, Ko Y-H, Fernando IPS, Cho K, Lee C-H, Hur S-P, Cho S-H, Ahn G, Kim D, Kim K-N (2016) Anti-inflammatory effect of supercritical extract and its constituents from Ishige okamurae. EXCLI J 15:434–445

    PubMed  PubMed Central  Google Scholar 

  • Kollmann C, Tremblay C, Giguel F, Chou TC, Hirsch MS (2001) In vitro anti-HIV-1 synergy between non-nucleoside reverse transcriptase inhibitors nevirapine and efavirenz. Antiviral Ther 6:143–144

    CAS  Google Scholar 

  • Kopelman PG (2000) Obesity as a medical problem. Nature 404:635–643

    Article  CAS  PubMed  Google Scholar 

  • Kumar V, Abbas AK, Fausto N, Aster JC (2014) Robbins and Cotran pathologic basis of disease, professional edition: expert consult. Elsevier Health Sciences

  • Lee KY, Mooney DJ (2012) Alginate: properties and biomedical applications. Prog Polym Sci 37:106–126

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee KM, Boo GH, Riosmena-Rodriguez R, Shin JA, Boo SM (2009) Classification of the genus Ishige (Ishigeales, Phaeophyceae) in the north pacific ocean with recognition of Ishige foliacea based on plastid Rbcl and mitochondrial Cox3 gene sequences. J Phycol 45:906–913

    Article  CAS  PubMed  Google Scholar 

  • Lee S-H, Choi J-I, Heo S-J, Park M-H, Park P-J, Jeon B-T, Kim S-K, Han J-S, Jeon Y-J (2012) Diphlorethohydroxycarmalol isolated from Pae (Ishige okamurae) protects high glucose-induced damage in RINm5F pancreatic β cells via its antioxidant effects. Food Sci Biotech 21:239–246

    Article  CAS  Google Scholar 

  • Lee W, Kang N, Kim E-A, Yang H-W, Oh J-Y, Fernando IPS, Kim K-N, Ahn G, Jeon Y-J (2017) Radioprotective effects of a polysaccharide purified from Lactobacillus plantarum-fermented Ishige okamurae against oxidative stress caused by gamma ray-irradiation in zebrafish in vivo model. J Funct Foods 28:83–89

    Article  CAS  Google Scholar 

  • LeRoith D, Taylor SI, Olefsky JM (2004) Diabetes mellitus: a fundamental and clinical text. Lippincott Williams & Wilkins, Philadelphia

  • Li B, Lu F, Wei X, Zhao R (2008) Fucoidan: structure and bioactivity. Molecules 13:1671–1695

    Article  CAS  PubMed  Google Scholar 

  • Martindale JL, Holbrook NJ (2002) Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 192:1–15

    Article  CAS  PubMed  Google Scholar 

  • Massoulié J, Pezzementi L, Bon S, Krejci E, Vallette F-M (1993) Molecular and cellular biology of cholinesterases. Prog Neurobiol 41:31–91

    Article  PubMed  Google Scholar 

  • Matsuno T (2001) Aquatic animal carotenoids. Fish Sci 67:771–783

    Article  CAS  Google Scholar 

  • Min KH, Kim HJ, Jeon YJ, Han JS (2011) Ishige okamurae ameliorates hyperglycemia and insulin resistance in C57BL/KsJ-db/db mice. Diabetes Res Clin Pract 93:70–76

  • Mohamed S, Hashim SN, Rahman HA (2012) Seaweeds: a sustainable functional food for complementary and alternative therapy. Trends Food Sci Technol 23:83–96

    Article  CAS  Google Scholar 

  • Murphy TF (2006) The role of bacteria in airway inflammation in exacerbations of chronic obstructive pulmonary disease. Curr Opin Infect Dis 19:225–230

    Article  PubMed  Google Scholar 

  • Nagase H, Woessner JF (1999) Matrix metalloproteinases. J Biol Chem 274:21491–21494

    Article  CAS  PubMed  Google Scholar 

  • Nakamura T, Nagayama K, Kawaguchi S (1994) High tocopherol content in a brown alga Ishige okamurae. Fish Sci 60:793–794

    Article  CAS  Google Scholar 

  • Nishide E, Anzai H, Uchida N, Nisizawa K (1990) Sugar constituents of fucose-containing polysaccharides from various Japanese brown algae. Hydrobiologia 204:573–576

    Article  Google Scholar 

  • O’Brien RD (2013) Toxic phosphorus esters: chemistry, metabolism, and biological effects. Elsevier, NY

  • Pari L, Rajarajeswari N (2009) Efficacy of coumarin on hepatic key enzymes of glucose metabolism in chemical induced type 2 diabetic rats. Chem Int 181:292–296

    CAS  Google Scholar 

  • Park MH, Jeon Y-J, Kim H-J, Han JS (2013) Effect of Diphlorethohydroxycarmalol isolated from Ishige okamurae on apoptosis in 3 t3-L1 preadipocytes. Phytother Res 27:931–936

    Article  CAS  PubMed  Google Scholar 

  • Parks W, Shapiro S (2001) Matrix metalloproteinases in lung biology. Respir Res 2:10–19

    Article  CAS  PubMed  Google Scholar 

  • Parks WC, Wilson CL, Lopez-Boado YS (2004) Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol 4:617–629

    Article  CAS  PubMed  Google Scholar 

  • Peng J, Yuan J-P, Wu C-F, Wang J-H (2011) Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health. Mar Drugs 9:1806–1828

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Popovic M, Sarin P, Robert-Gurroff M, Kalyanaraman V, Mann D, Minowada J, Gallo R (1983) Isolation and transmission of human retrovirus (human t-cell leukemia virus). Science 219:856–859

    Article  CAS  PubMed  Google Scholar 

  • Prabhasankar P, Ganesan P, Bhaskar N, Hirose A, Stephen N, Gowda LR, Hosokawa M, Miyashita K (2009) Edible Japanese seaweed, wakame (Undaria pinnatifida) as an ingredient in pasta: chemical, functional and structural evaluation. Food Chem 115:501–508

    Article  CAS  Google Scholar 

  • Qu J, Wang X, Chi S, Wu S, Sun J, Liu C, Chen S, Yu J, Liu T (2014) Transcriptome characterization of Ishige okamurae (Phaeophyceae) shows strong environmental acclimation. Acta Oceanol Sinica 33(2):20

    Article  CAS  Google Scholar 

  • Ragan MA, Glombitza K-W (1986) Phlorotannins, brown algal polyphenols. Prog Phycol Res 4:129–241

    CAS  Google Scholar 

  • Rayalam S, Della-Fera MA, Baile CA (2008) Phytochemicals and regulation of the adipocyte life cycle. J Nut Biochem 19:717–726

    Article  CAS  Google Scholar 

  • Rioux LE, Turgeon SL, Beaulieu M (2007) Characterization of polysaccharides extracted from brown seaweeds. Carbohydr Polym 69:530–537

    Article  CAS  Google Scholar 

  • Rosenberg GA, Estrada EY, Dencoff JE (1998) Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. Stroke 29:2189–2195

    Article  CAS  PubMed  Google Scholar 

  • Sadikot RT, Blackwell TS, Christman JW, Prince AS (2005) Pathogen–host interactions in Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med 171:1209–1223

    Article  PubMed  PubMed Central  Google Scholar 

  • Schaeffer DJ, Krylov VS (2000) Anti-HIV activity of extracts and compounds from algae and cyanobacteria. Ecotoxicol Environ Saf 45:208–227

    Article  CAS  PubMed  Google Scholar 

  • Sélo I, Créminon C, Grassi J, Couraud J-Y (2002) Anti-allergen antibodies can be neutralized by antibodies obtained against a peptide complementary to the allergen: towards a new peptide therapy for allergy. Immunol Lett 80:133–138

    Article  PubMed  Google Scholar 

  • Sithranga BN (2010) Kathiresan K (2010) anticancer drugs from marine flora: an overview. J Oncol. doi:10.1155/2010/214186

  • Sitkiewicz I, Stockbauer KE, Musser JM (2007) Secreted bacterial phospholipase A2 enzymes: better living through phospholipolysis. Trends Microbiol 15:63–69

    Article  CAS  PubMed  Google Scholar 

  • Smit A (2004) Medicinal and pharmaceutical uses of seaweed natural products: a review. J Appl Phycol 16:245–262

    Article  CAS  Google Scholar 

  • Sun J-Z, Ning X-R, Le F-F, Chen W-D, Zhuang D-G (2010) Long term changes of biodiversity of benthic macroalgae in the intertidal zone of the Nanji Islands. Acta Ecol Sin 30(2):106–112

    Article  CAS  Google Scholar 

  • The American Diabetes Association (2014) Standards of medical care in diabetes—2014. Diabetes Care 37 (Supplement 1):S14–S80

  • Thomas N, Kim S-K (2013) Beneficial effects of marine algal compounds in cosmeceuticals. Mar Drugs 11:146–164

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tückmantel W, Kozikowski AP, Romanczyk LJ (1999) Studies in polyphenol chemistry and bioactivity. 1. Preparation of building blocks from (+)-catechin. Procyanidin formation. Synthesis of the cancer cell growth inhibitor, 3-O-Galloyl-(2R,3R)-epicatechin-4β,8-[3-O-galloyl-(2R,3R)-epicatechin]. J Am Chem Soc 121:12073–12081

    Article  Google Scholar 

  • UNAIDS (2016) AIDS by the number. http://www.unaids.org/sites/default/files/media_asset/AIDS-by-the-numbers-2016_en.pdf

  • Van Alstyne K, Paul V (1990) The biogeography of polyphenolic compounds in marine macroalgae: temperate brown algal defenses deter feeding by tropical herbivorous fishes. Oecologia 84:158–163

    Article  PubMed  Google Scholar 

  • Vassort G, Turan B (2010) Protective role of antioxidants in diabetes-induced cardiac dysfunction. Cardiovasc Toxicol 10:73–86

    Article  CAS  PubMed  Google Scholar 

  • Vo T-S, Kim J-A, Wijesekara I, Kong C-S, Kim S-K (2011) Potent effect of brown algae (Ishige okamurae) on suppression of allergic inflammation in human basophilic KU812F cells. Food Sci Biotech 20:1227–1234

    Article  CAS  Google Scholar 

  • Wang PH, Lau J, Chalmers TC (1993) Meta-analysis of effects of intensive blood-glucose control on late complications of type I diabetes. Lancet 341:1306–1309

    Article  CAS  PubMed  Google Scholar 

  • WHO (2014) Global status report on non-communicable diseases. p 298

  • WHO (2016) Global report on diabetes. Geneva, p 87

  • WHO (2017) Cancer fact sheet February 2017. http://www.who.int/mediacentre/factsheets/fs297/en/

  • Wijesekara I, Pangestuti R, Kim S-K (2011) Biological activities and potential health benefits of sulfated polysaccharides derived from marine algae. Carbohydr Polym 84:14–21

    Article  CAS  Google Scholar 

  • Woessner JF (1998) Role of matrix proteases in processing enamel proteins. Conn Tissue Res 39:69–73

    Article  Google Scholar 

  • Wright CI, Geula C, Mesulam MM (1993) Neuroglial cholinesterases in the normal brain and in Alzheimer’s disease: relationship to plaques, tangles, and patterns of selective vulnerability. Ann Neurol 34:373–384

    Article  CAS  PubMed  Google Scholar 

  • Xiaojun Y, Xiancui L, Chengxu Z, Xiao F (1996) Prevention of fish oil rancidity by phlorotannins from Sargassum kjellmanianum. J Appl Phycol 8:201–203

    Article  CAS  Google Scholar 

  • Yoon NY, Lee S-H, Yong L, Kim S-K (2009) Phlorotannins from Ishige okamurae and their acetyl- and butyrylcholinesterase inhibitory effects. J Funct Foods 1:331–335

    Article  CAS  Google Scholar 

  • Zou Y, Qian Z-J, Li Y, Kim M-M, Lee S-H, Kim S-K (2008) Antioxidant effects of phlorotannins isolated from Ishige okamurae in free radical mediated oxidative systems. J Agric Food Chem 56:7001–7009

    Article  CAS  PubMed  Google Scholar 

  • Zou Y, Li Y, Kim M-M, Lee S-H, Kim S-K (2009) Ishigoside, a new glyceroglycolipid isolated from the brown alga Ishige okamurae. Biotech Bioproc Eng 14:20–26

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This study was a part of the project titled “Development of overseas marine bioresources and a system for their utilization,” funded by the Ministry of Oceans and Fisheries, Korea (Grant No. 2016-0804).

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Jae-Il Kim or You-Jin Jeon.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Asanka Sanjeewa, K.K., Lee, W.W., Kim, JI. et al. Exploiting biological activities of brown seaweed Ishige okamurae Yendo for potential industrial applications: a review. J Appl Phycol 29, 3109–3119 (2017). https://doi.org/10.1007/s10811-017-1213-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10811-017-1213-4

Keywords

Navigation