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Seaweed extracts as antimicrobial agents in aquaculture

  • 5th Congress of the International Society for Applied Phycology
  • Published:
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Abstract

In the last 20 years, there has been an increasing interest in using various seaweed extracts as prophylactic and/or therapeutic agents in aquaculture. Up until now, most studies on the direct antimicrobial effect of seaweeds have taken place in various parts of Asia, particularly in India. All groups of seaweeds exhibit significant antimicrobial properties against many infectious agents of fish and shrimp, but the genera that appear to exhibit a broader range of antibacterial properties are Asparagopsis spp. (red seaweed) and Sargassum spp. (brown seaweed). The activity can be affected by many factors and the method of extraction is one of the most important ones, as the extracts that are produced using organic solvents appear more efficient. In fish, almost all published information on bacterial pathogens comes from in vitro screenings, where extracts of different seaweed species were tested against many bacterial species. On the other hand, in shrimp, the studies have been focusing on the antimicrobial effects of seaweed extracts mainly against many Vibrio species. Regarding the viral pathogens, in fish, there is only one published study on fish viruses (IHNV and IPNV), while in shrimp there are many studies on WSSV. There are only two published studies on fish parasites (Ichthyophonus hoferi and Neobendenia spp.) and no studies on pathogenic fish and shrimp fungi. Interestingly, there are no published studies on salmons and carps, the main fish species that are extensively farmed. When the antimicrobial properties were studied in vivo, the seaweed extracts were either incorporated directly in the feeds (dry or live) or added directly into the water in which the fish and shrimp were reared. In the last case, the water-soluble antimicrobial seaweed substances affected the communication between the bacterial pathogens, rather than their growth. The development of parasites was also affected. In addition, one study indicated that short-term immersion of shrimp in seaweed extracts appeared to have a therapeutic effect against Vibrio parahaemolyticus. On the other hand, incorporation of the extracts into the feeds appeared to be an effective delivery method for the prevention and treatment of different infectious diseases. Up until now, there are no complete studies on the pharmacodynamics and pharmacokinetics of seaweed extracts in fish or shrimp. However, the findings indicate that they can reduce the bacterial load within the tissues. Another issue that has not been examined yet is the applicability of using these extracts on a commercial scale. Currently, the increased extraction cost inhibits the extensive use of these extracts. Other methodologies, such the production of synthetic analogues with similar properties, may decrease the production cost. Based on the published studies, seaweed extracts exhibit promising antimicrobial properties, but further research is needed before the complete potential of seaweed extracts is assessed.

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References

  • Aarestrup FM, Jensen VF, Emborg HD, Jacobsen E, Wegener HC (2010) Changes in the use of antimicrobials and the effects on productivity of swine farms in Denmark. Am J Vet Res 71:726–33

    Article  PubMed  Google Scholar 

  • Abu-Ghannam N, Rajauria G (2013) Antimicrobial activity of compounds isolated from algae. In: Domínguez H (ed) Functional ingredients from algae for foods and nutraceuticals. Woodhead, Sawston, pp 287–306

    Chapter  Google Scholar 

  • Ahn MJ, Yoon KD, Min SY, Lee JS, Kim JH, Kim TG, Kim SH, Kim NG, Huh H, Kim J (2004) Inhibition of HIV-1 reverse transcriptase and protease by phlorotannins from the brown alga Ecklonia cava. Biol Pharm Bull 27:544–547

    Article  CAS  PubMed  Google Scholar 

  • Al-Hafedh YS, Alam A, Buschmann AH, Fitzsimmons KM (2012) Experiments on an integrated aquaculture system (seaweeds and marine fish) on the Red Sea coast of Saudi Arabia: efficiency comparison of two local seaweed species for nutrient biofiltration and production. Rev Aquac 4:21–31

    Article  Google Scholar 

  • Bailey SE, Olin TJ, Bricka RM, Adrian DD (1999) A review of potentially low-cost sorbents for heavy metals. Water Res 33:2469–2479

    Article  CAS  Google Scholar 

  • Balasubramanian G, Sudhakaran R, Syed Musthaq S, Sarathi M, Sahul Hameed AS (2006) Studies on the inactivation of white spot syndrome virus of shrimp by physical and chemical treatments, and seaweed extracts tested in marine and freshwater animal models. J Fish Dis 29:569–572

    Article  CAS  PubMed  Google Scholar 

  • Baleta FN, Laureta LV, Apines-Amar MJS, Padilla PIP, Quinitio GF (2011) Biological activity of extracts of Sargassum oligocystum (Magnaye) against aquaculture pathogenic bacteria. Isr J Aquac IIC 63(2011):667

    Google Scholar 

  • Bansemir A, Just N, Michalik M, Lindequist U, Lalk M (2004) Extracts and sesquiterpene derivatives from the red alga Laurencia chondrioides with antibacterial activity against fish and human pathogenic bacteria. Chem Biodivers 1:463–467

    Article  CAS  PubMed  Google Scholar 

  • Bansemir A, Blume M, Schröder S, Lindequist U (2006) Screening of cultivated seaweeds for antibacterial activity against fish pathogenic bacteria. Aquaculture 252:79–84

    Article  Google Scholar 

  • Barrington K, Chopin T, Robinson S (2009) Integrated multi-trophic aquaculture (IMTA) in marine temperate waters. In: D. Soto (ed). Integrated mariculture: a global review. FAO Fisheries and Aquaculture Technical Paper. No. 529. Rome, FAO, pp 7–46

  • Bianco EM, Pires L, Santos GKN, Dutra KA, Reis TNV, Vasconcelos ERTPP, Cocentino ALM, Navarro DMAF (2013) Larvicidal activity of seaweeds from northeastern Brazil and of a halogenated sesquiterpene against the dengue mosquito (Aedes aegypti). Ind Crop Prod 43:270–275

    Article  CAS  Google Scholar 

  • Bindu MS, Sobha V (2004) Conversion efficiency and nutrient digestibility of certain seaweed diets by laboratory reared Labeo rohita (Hamilton). Indian J Exp Biol 42:1239–1244

    CAS  PubMed  Google Scholar 

  • Bruton T, Lyons H, Lerat Y, Stanley M, Rasmussen MB (2009) A review of the potential of marine algae as a source of biofuel in Ireland. Report prepared for Sustainable Energy Ireland. http://www.seai.ie/Publications/Renewables_Publications_/Bioenergy/Algaereport.pdf. Accessed 30 Oct 2014

  • Buchholz CM, Krause G, Buck BH (2012) Seaweed and man. In: Wiencke C, Bischof K (eds) Seaweed biology. Springer, Berlin, pp 471–493

    Chapter  Google Scholar 

  • Buck CB, Thompson CD, Roberts JN, Muller M, Lowy DR, Schiller JT (2006) Carrageenan is a potent inhibitor of papillomavirus infection. PLoS Pathog 2(7):e69

    Article  PubMed  PubMed Central  Google Scholar 

  • Burridge L, Weis J, Cabello F, Pizarro J, Bostick K (2010) Chemical use in salmon aquaculture: a review of current practices and possible environmental effects. Aquaculture 306:7–23

    Article  CAS  Google Scholar 

  • Cai J, Feng J, Xie S, Wang F, Xu Q (2014) Laminaria japonica extract, an inhibitor of Clavibater michiganense subsp. sepedonicum. PLoS One 9(4):e94329

    Article  PubMed  PubMed Central  Google Scholar 

  • Caipang CMA, Lazado CC, Berg I, Brinchmann MF, Viswanath K (2011) Influence of alginic acid and fucoidan on the immune responses of head kidney leukocytes in cod. Fish Physiol Biochem 37:603–612

    Article  CAS  PubMed  Google Scholar 

  • Cavallo RA, Acquaviva M, Stabili L, Cecere E, Petrocelli A, Narracci M (2013) Antibacterial activity of marine macroalgae against fish pathogenic Vibrio species. Cent Eur J Biol 8:646–653

    CAS  Google Scholar 

  • Chiu YH, Chan YL, Li TL, Wu CJ (2012) Inhibition of Japanese encephalitis virus infection by the sulfated polysaccharide extracts from Ulva lactuca. Mar Biotech 14:468–478

    Article  CAS  Google Scholar 

  • Chotigeat W, Tongsupa S, Supamataya K, Phongdara A (2004) Effect of fucoidan on disease resistance of black tiger shrimp. Aquaculture 233:23–30

    Article  CAS  Google Scholar 

  • Christobel JG, Lipton AP, Aishwarya MS, Sarika AR, Udayakumar A (2011) Antibacterial activity of aqueous extract from selected macroalgae of southwest coast of India. Seaweed Res Util 33:67–75

    Google Scholar 

  • Costello MJ (2009) The global economic cost of sea lice to the salmonid farming industry. J Fish Dis 32:115–118

    Article  PubMed  Google Scholar 

  • Dashtiannasab A, Kakoolaki S, Sharif Rohani M, Yeganeh V (2012) In vitro effects of Sargassum latifolium (Agardeh, 1948) against selected bacterial pathogens of shrimp. Iran J Fish Sci 11(4):765–775

    Google Scholar 

  • Dawczynski C, Schubert R, Jahreis G (2007) Amino acids, fatty acids, and dietary fibre in edible seaweed products. Food Chem 103:891–899

    Article  CAS  Google Scholar 

  • de Lara-Isassi G, Álvarez-Hernández S, Collado-Vides L (2000) Ichtyotoxic activity of extracts from Mexican marine macroalgae. J Appl Phycol 12:45–52

    Article  Google Scholar 

  • Defoirdt T, Crab R, Wood TK, Sorgeloos P, Verstraete W, Bossier P (2006) Quorum sensing-disrupting brominated furanones protect the gnotobiotic brine shrimp Artemia franciscana from pathogenic Vibrio harveyi, Vibrio campbellii, and Vibrio parahaemolyticus isolates. Appl Environ Microbiol 72:6419–6423

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dillehay TD, Ramírez C, Pino M, Collins MB, Rossen J, Pino-Navarro JD (2008) Monte Verde: seaweed, food, medicine, and the peopling of South America. Science 320:784–786

    Article  CAS  PubMed  Google Scholar 

  • Dobretsov S, Teplitski M, Paul V (2009) Mini-review: quorum sensing in the marine environment and its relationship to biofouling. Biofouling 25:413–427

    Article  CAS  PubMed  Google Scholar 

  • Dubber D, Harder T (2008) Extracts of Ceramium rubrum, Mastocarpus stellatus and Laminaria digitata inhibit growth of marine and fish pathogenic bacteria at ecologically realistic concentrations. Aquaculture 274:196–200

    Article  Google Scholar 

  • El Gamal AA (2010) Biological importance of marine algae. Saudi Pharm J 18:1–25

    Article  PubMed  Google Scholar 

  • El Ghany NAA, Alla HMLA (2008) A trial for treatment of ichthyophonosis in cultured Oreochromis niloticus using fucus and neem plants. 8th International Symposium on Tilapia in Aquaculture. Proceedings. Cairo, Egypt, 12–14 October, 2008. pp. 1329–1349

  • Food and Agriculture Organization of the United Nations (FAO) (2014) Global aquaculture production. http://www.fao.org/fishery/statistics/global-aquaculture-production/en. Accessed 14 May 2014

  • Ganeshamurthy R, Kumar TTA, Dhayanithi NB (2012) Effect of secondary metabolites of the seaweed (Halimeda micronesia) at Lakshadweep islands against aquatic pathogens. Int J Pharm Bio Sci 3:B213–B220

    Google Scholar 

  • Genovese G, Faggio C, Gugliandolo C, Torre A, Spanò A, Morabito M, Maugeri TL (2012) In vitro evaluation of antibacterial activity of Asparagopsis taxiformis from the Straits of Messina against pathogens relevant in aquaculture. Mar Environ Res 73:1–6

    Article  CAS  PubMed  Google Scholar 

  • Govindasamy C, Narayani S, Arulpriya M, Ruban P, Anantharaj K, Srinivasan R (2011) In vitro antimicrobial activities of seaweed extracts against human pathogens. J Pharm Res 4:2076–2077

    Google Scholar 

  • Gupta S, Abu-Ghannam N (2011a) Bioactive potential and possible health effects of edible brown seaweeds. Trends Food Sci Tech 22:315–326

    Article  CAS  Google Scholar 

  • Gupta S, Abu-Ghannam N (2011b) Recent developments in the application of seaweeds or seaweed extracts as a means for enhancing the safety and quality of foods. Innov Food Sci Emerg 12:600–609

    Article  CAS  Google Scholar 

  • Henry EC (2012) The use of algae in fish feeds as alternatives to fish meals. http://users.auth.gr/kganias/Aquaculture/AQUAFEED_selection.pdf. Accessed May 14 2014

  • Heuer OE, Kruse H, Grave K, Collignon P, Karunasagar I, Angulo FJ (2009) Human health consequences of use of antimicrobial agents in aquaculture. Clin Infect Dis 49:1248–1253

    Article  PubMed  Google Scholar 

  • Hierholtzer A, Chatellard L, Kierans M, Akunna JC, Collier PJ (2013) The impact and mode of action of phenolic compounds extracted from brown seaweed on mixed anaerobic microbial cultures. J Appl Microbiol 114:964–973

  • Higa T, Kuniyoshi M (2000) Toxins associated with medicinal and edible seaweeds. J Toxicol Toxin Rev 19:119–137

    Article  CAS  Google Scholar 

  • Holdt SL, Kraan S (2011) Bioactive compounds in seaweed: functional food applications and legislation. J Appl Phycol 23:543–597

    Article  CAS  Google Scholar 

  • Huntingford FA, Adams C, Braithwaite VA, Kadri S, Pottinger TG, Sandøe P, Turnbull JF (2006) Current issues in fish welfare. J Fish Biol 68:332–372

    Article  Google Scholar 

  • Hutson KS, Mata L, Paul NA, de Nys R (2012) Seaweed extracts as a natural control against the monogenean ectoparasite, Neobenedenia sp., infecting farmed barramundi (Lates calcarifer). Int J Parasitol 42:1135–1141

    Article  PubMed  Google Scholar 

  • Ibañez E, Herrero M, Mendiola JA, Castro-Puyana M (2012) Extraction and characterization of bioactive compounds with health benefits from marine resources: macro and micro algae, cyanobacteria, and invertebrates. In: Hayes M (ed) Marine bioactive compounds: sources, characterization and applications. Springer, Berlin, pp 55–98

    Chapter  Google Scholar 

  • Immanuel G, Vincybai VC, Sivaram V, Palavesam A, Marian MP (2004) Effect of butanolic extracts from terrestrial herbs and seaweeds on the survival, growth and pathogen (Vibrio parahaemolyticus) load on shrimp Penaeus indicus juveniles. Aquaculture 236:53–65

    Article  Google Scholar 

  • Immanuel G, Sivagnanavelmurugan M, Balasubramanian V, Palavesam A (2010) Effect of hot water extracts of brown seaweeds Sargassum spp. on growth and resistance to white spot syndrome virus in shrimp Penaeus monodon postlarvae. Aquac Res 41:e545–e553

    Article  CAS  Google Scholar 

  • Immanuel G, Sivagnanavelmurugan M, Balasubramanian V, Palavesam A (2012) Sodium alginate from Sargassum wightii retards mortalities in Penaeus monodon postlarvae challenged with white spot syndrome virus. Dis Aquat Org 99:187–196

    Article  CAS  PubMed  Google Scholar 

  • Jha B, Kavita K, Westphal J, Hartmann A, Schmitt-Kopplin P (2013) Quorum sensing inhibition by Asparagopsis taxiformis, a marine macro alga: separation of the compound that interrupts bacterial communication. Mar Drugs 11:253–265

    Article  PubMed  PubMed Central  Google Scholar 

  • Jiao G, Yu G, Wang W, Zhao X, Zhang J, Ewart SH (2012) Properties of polysaccharides in several seaweeds from Atlantic Canada and their potential anti-influenza viral activities. J Ocean Univ China 11:205–212

    Article  CAS  Google Scholar 

  • Johansen LH, Jensen I, Mikkelsen H, Bjørn PA, Jansen PA, Bergh Ø (2011) Disease interaction and pathogens exchange between wild and farmed fish populations with special reference to Norway. Aquaculture 315:167–186

    Article  Google Scholar 

  • Kang MC, Kim KN, Kang SM, Yang X, Kim EA, Song CB, Nah JW, Jang MK, Lee JS, Jung WK, Jeon YJ (2013) Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebra fish model. Environ Toxicol Pharmacol 36:1217–1226

    Article  CAS  PubMed  Google Scholar 

  • Kanjana K, Radtanatip T, Asuvapongpatana S, Withyachumnarnkul B, Wongprasert K (2011) Solvent extracts of the red seaweed Gracilaria fisheri prevent Vibrio harveyi infections in the black tiger shrimp Penaeus monodon. Fish Shellfish Immunol 30:389–396

    Article  PubMed  Google Scholar 

  • Karthikaidevi G, Manivannan K, Thirumaran G, Anantharaman P, Balasubaramanian T (2009) Antibacterial properties of selected green seaweeds from Vedalai coastal waters; Gulf of Mannar marine biosphere reserve. Glob J Pharmacol 3:107–112

    Google Scholar 

  • Kibenge FSB, Godoy MG, Fast M, Workenhe S, Kibenge MJT (2012) Countermeasures against viral diseases of farmed fish. Antivir Res 95:257–281

    Article  CAS  PubMed  Google Scholar 

  • Kim SY, Kim SR, Oh MJ, Jung SJ, Kang SY (2011) In vitro antiviral activity of red alga, Polysiphonia morrowii extract and its bromophenols against fish pathogenic infectious hematopoietic necrosis virus and infectious pancreatic necrosis virus. J Microbiol 49:102–106

    Article  CAS  PubMed  Google Scholar 

  • Lu K, Lin W, Liu J (2008) The characteristics of nutrient removal and inhibitory effect of Ulva clathrata on Vibrio anguillarum 65. J Appl Phycol 20:1061–1068

    Article  Google Scholar 

  • Maheswaran ML, Padmavathy S, Gunalan B (2013) Screening and characterization of marine seaweeds and its antimicrobial potential against fish pathogens. Int J Fish Aquat Stud 1:1–13

    Google Scholar 

  • Manefield M, Harris L, Rice SA, de Nys R, Kjelleberg S (2000) Inhibition of luminescence and virulence in the black tiger prawn (Penaeus monodon) pathogen Vibrio harveyi by intercellular signal antagonists. Appl Environ Microbiol 66:2079–2084

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Manefield M, Welch M, Givskov M, Salmond GPC, Kjelleberg S (2001) Halogenated furanones from the red alga, Delisea pulchra, inhibit carbapenem antibiotic synthesis and exoenzyme virulence factor production in the phytopathogen Erwinia carotovora. FEMS Microbiol Lett 205:131–138

    Article  CAS  PubMed  Google Scholar 

  • Manilal A, Sujith S, Selvin J, Seghal Kiran G, Shakir C (2009) In vivo antiviral activity of polysaccharide from the Indian green alga, Acrosiphonia orientalis (J. Agardh): potential implication in shrimp disease management. World J Fish Mar Sci 1:278–282

    CAS  Google Scholar 

  • Manilal A, Selvin J, George S (2012) In vivo therapeutic potentiality of red seaweed, Asparagopsis (Bonnemaisoniales, Rhodophyta) in the treatment of vibriosis in Penaeus monodon Fabricius. Saudi J Biol Sci 19:165–175

    Article  PubMed  Google Scholar 

  • Martinez JL (2009) The role of natural environments in the evolution of resistance traits in pathogenic bacteria. Proc R Soc B 276:2521–2530

    Article  PubMed  PubMed Central  Google Scholar 

  • Marudhupandi T, Kumar TTA (2013) Antibacterial effect of fucoidan from Sargassum wightii against the chosen human bacterial pathogens. Int Curr Pharm J 2:156–158

    Article  CAS  Google Scholar 

  • Mata L, Wright E, Owens L, Paul N, de Nys R (2013) Water-soluble natural products from seaweed have limited potential in controlling bacterial pathogens in fish aquaculture. J Appl Phycol 25:1963–1973

    Article  CAS  Google Scholar 

  • McLoughlin M (2006) Fish vaccination—a brief overview. http://www.imb.ie/images/uploaded/documents/Fish%20Vaccine%20Overview.pdf. Accessed 14 May 2014

  • Miranda CD, Zemelman R (2002) Bacterial resistance to oxytetracycline in Chilean salmon farming. Aquaculture 212:31–47

    Article  CAS  Google Scholar 

  • Mohamed S, Hashim SN, Rahman HA (2012) Seaweeds: a sustainable functional food for complementary and alternative therapy. Trends Food Sci Technol 23:83–96

    Article  CAS  Google Scholar 

  • Moo-Puc R, Robledo D, Freile-Pelegrin Y (2008) Evaluation of selected tropical seaweeds for in vitro anti-trichomonal activity. J Ethnopharmacol 120:92–97

    Article  CAS  PubMed  Google Scholar 

  • Omar HH, Gumgumji NM, Shiek HM, El Kazan MM, El Gendy AM (2012) Inhibition of the development of pathogenic fungi by extracts of some marine algae from the Red Sea of Jeddah, Saudi Arabia. Afr J Biotechnol 11:13697–13704

    Google Scholar 

  • Osman MEH, Abu-Shady AM, Elshobary ME (2012) The seasonal fluctuation of the antimicrobial activity of some macroalgae collected from Alexandria Coast, Egypt. In: Annous BA, Gurtler JB (eds) Salmonella: distribution, adaptation, control measures and molecular technologies, InTech, pp 173–186

  • Patel S (2012) Therapeutic importance of sulfated polysaccharides from seaweeds: updating the recent findings. 3 Biotechnol 2:171–185

    Google Scholar 

  • Pereira RC, Costa-Lotufo LV (2012) Bioprospecting for bioactives from seaweeds: potential, obstacles and alternatives. Rev Bras Farmacogn Braz J Pharmacogn 22:894–905

    Article  CAS  Google Scholar 

  • Petersen A, Andersen JS, Kaewmak T, Somsiri T, Dalsgaard A (2002) Impact of integrated fish farming on antimicrobial resistance in a pond environment. Appl Environ Microbiol 68:6036–6042

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Plaza M, Cifuentes A, Ibáñez E (2008) In the search of new functional food ingredients from algae. Trends Food Sci Technol 19:31–39

    Article  CAS  Google Scholar 

  • Plaza M, Santoyo S, Jaime L, García-Blairsy Reina G, Herrero M, Señoráns FJ, Ibáñez E (2010) Screening for bioactive compounds from algae. J Pharm Biomed Anal 51:450–455

    Article  CAS  PubMed  Google Scholar 

  • Radhika D, Veerabahu C, Priya R, Mohaideen A (2014) A comparative study of biopotential of crude and fractionated extracts of some sea weeds from Tuticorin coast. Int J Phytopharmacol 5:27–30

    Google Scholar 

  • Rasch M, Buch C, Austin B, Slierendrecht WJ, Ekmann KS, Larsen JL, Johansen C, Riedel K, Eberl L, Givskov M, Gram L (2004) An inhibitor of bacterial quorum sensing reduces mortalities caused by vibriosis in rainbow trout (Oncorhynchus mykiss, Walbaum). Syst Appl Microbiol 27:350–359

    Article  CAS  PubMed  Google Scholar 

  • Rebecca LJ, Dhanalakshmi V, Sharmila S (2012) Effect of the extract of Ulva sp on pathogenic microorganisms. J Chem Pharm Res 4:4875–4878

    Google Scholar 

  • Romero J, Feijoó CG, Navarrete P (2012) Antibiotics in Aquaculture – Use, Abuse and Alternatives. In: Carvalho ED, David GS, Silva RJ (eds) Health and environment in aquaculture. InTech, Croatia, pp 159–198

    Google Scholar 

  • Rudtanatip T, Asuvapongpatana S, Withyachumnarnkul B, Wongprasert K (2014) Sulfated galactans isolated from the red seaweed Gracilaria fisheri targeted the envelope proteins of white spot syndrome virus and protected against viral infection in shrimp haemocytes. J Gen Virol. doi:10.1099/vir. 0.062919-0

    PubMed  Google Scholar 

  • Rutherford ST, Bassler BL (2012) Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harb Perspect Med 2:a012427

  • Saha S, Navid MH, Bandyopadhyay SS, Schnitzler P, Ray B (2012) Sulfated polysaccharides from Laminaria angustata: structural features and in vitro antiviral activities. Carbohydr Polym 87:123–130

    Article  CAS  Google Scholar 

  • Salvador N, Garreta AG, Lavelli L, Ribera MA (2007) Antimicrobial activity of Iberian macroalgae. Sci Mar 71:101–113

    Article  Google Scholar 

  • Saritha K, Mani AE, Priyalaxmi M, Patterson J (2013) Antibacterial activity and biochemical constituents of seaweed Ulva lactuca. Glob J Pharmacol 7:276–282

    CAS  Google Scholar 

  • Selvin J, Manilal A, Sujith S, Kiran GS, Lipton AP (2011) Efficacy of marine green alga Ulva fasciata extract on the management of shrimp bacterial diseases. Lat Am J Aquat Res 39:197–204

    Article  Google Scholar 

  • Silva GC, Albuquerque-Costa R, Oliveira-Peixoto JR, Pessoa-Nascimento FE, de Macedo-Carneiro PB, dos Fernandes-Vieira RHS (2013) Tropical Atlantic marine macroalgae with bioactivity against virulent and antibiotic resistant Vibrio. Lat Am J Aquat Res 41:183–188

    Article  Google Scholar 

  • Singh M, Manikandan S, Kumaraguru AK (2012) In vitro antibacterial activity of selected brown marine macroalgae extracts collected from the Pudumadam Coast of “Gulf of Mannar” region against fish pathogens. Int J Human Genet Med Biotechnol Microbiol Stud. ISSN (Online) 2319–1732

  • Sirirustananun N, Chen JC, Lin YC, Yeh ST, Liou CH, Chen LL, Sim SS, Chiew SL (2011) Dietary administration of a Gracilaria tenuistipitata extract enhances the immune response and resistance against Vibrio alginolyticus and white spot syndrome virus in the white shrimp Litopenaeus vannamei. Fish Shellfish Immunol 31:848–855

    Article  PubMed  Google Scholar 

  • Sivagnanavelmurugan M, Marudhupandi T, Palavesam A, Immanuel G (2012) Antiviral effect of fucoidan extracted from the brown seaweed, Sargassum wightii, on shrimp Penaeus monodon postlarvae against White Spot Syndrome Virus. J World Aquacult Soc 43:697–706

    Article  Google Scholar 

  • Sivakumar K, Kannappan S, Dineshkumar M, Patil PK (2014) Evaluation of marine macro alga, Ulva fasciata against bio-luminescent causing Vibrio harveyi during Penaeus monodon larviculture. Afr J Microbiol Res 8:803–813

    Article  Google Scholar 

  • Smit AJ (2004) Medicinal and pharmaceutical uses of seaweed natural products: a review. J Appl Phycol 16:245–262

    Article  CAS  Google Scholar 

  • Son M, Lee M, Sung GH, Lee T, Shin YS, Cho H, Lieberman PM, Kang H (2013) Bioactive activities of natural products against Herpesvirus infection. J Microbiol 51:545–551

    Article  CAS  PubMed  Google Scholar 

  • Stern J, Hagerman A, Steinberg P, Magon P (1996) Phlorotannin–protein interactions. J Chem Ecol 22:1877–1899

    Article  CAS  PubMed  Google Scholar 

  • Sudheer NS, Philip R, Singh ISB (2012) Anti-white spot syndrome virus activity of Ceriops tagal aqueous extract in giant tiger shrimp Penaeus monodon. Arch Virol 157:1665–1675

    Article  CAS  PubMed  Google Scholar 

  • Takahashi Y, Uehara K, Watanabe R, Okumura T, Yamashita T, Omura H, Yomo T, Kawano T, Kanemitsu A, Narasaka H, Suzuki N, Itami T (1998) Efficacy of oral administration of fucoidan, a sulfated polysaccharide, in controlling white spot syndrome in kuruma shrimp in Japan. In: Flegel TW (ed) Advances in shrimp biotechnology. National Center for Genetic Engineering and Biotechnology, Bangkok, pp 171–173

    Google Scholar 

  • Thanigaivel S, Vijayakumar S, Mukherjee A, Chandrasekaran N, Thomas J (2014) Antioxidant and antibacterial activity of Chaetomorpha antennina against shrimp pathogen Vibrio parahaemolyticus. Aquaculture 433:467–475

    Article  Google Scholar 

  • The Fish Site (2010) Aquatic animal diseases and their economic impact. http://www.thefishsite.com/articles/896/aquatic-animal-diseases-and-their-economic-impact#sthash.CrjIsPk9.dpuf. Accessed 11 March 2014

  • Traifalgar RF, Serrano AE, Corre V, Kira H, Tung HT, Michael FR, Kader MA, Laining A (2009) Evaluation of dietary fucoidan supplementation effects on growth performance and vibriosis resistance of Penaeus monodon postlarvae. Aquac Sci 57:167–174

    CAS  Google Scholar 

  • Vairappan CS, Suzuki M (2000) Dynamics of total surface bacteria and bacterial species counts during desiccation in the Malaysian sea lettuce, Ulva reticulata (Ulvales, Chlorophyta). Phycol Res 48:55–61

    Article  Google Scholar 

  • Vairappan CS, Daitoh M, Suzuki M, Abe T, Masuda M (2001) Antibacterial halogenated metabolites from the Malaysian Laurencia species. Phytochemistry 58:291–297

    Article  CAS  PubMed  Google Scholar 

  • Vijayabaskar P, Shiyamala V (2011) Antibacterial activities of brown marine algae (Sargassum wightii and Turbinaria ornata) from the Gulf of Mannar biosphere reserve. Advan Biol Res 5:99–102

    Google Scholar 

  • Vonthron-Sénécheau C, Kaiser M, Devambez I, Vastel A, Mussio I, Rusig AM (2011) Antiprotozoal activities of organic extracts from French marine seaweeds. Mar Drugs 9:922–933

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang W, Wang SX, Guan HS (2012) The antiviral activities and mechanisms of marine polysaccharides: an overview. Mar Drugs 10:2795–2816

    Article  PubMed  PubMed Central  Google Scholar 

  • Wijesinghe WAJP, Kim EA, Kang MC, Lee WW, Lee HS, Vairappan CS, Jeon YJ (2014) Assessment of anti-inflammatory effect of 5-hydroxypalisadin B isolated from red seaweed Laurencia snackeyi in zebrafish embryo in vivo model. Environ Toxicol Pharmacol 37:110–117

    Article  CAS  PubMed  Google Scholar 

  • World Health Organization (2011) Tackling antibiotic resistance from a food safety perspective in Europe. http://www.euro.who.int/__data/assets/pdf_file/0005/136454/e94889.pdf Accessed 16 Oct 2014

  • Xu N, Fan X, Yan X, Li X, Niu R, Tseng CK (2003) Antibacterial bromophenols from the marine red alga Rhodomela confervoides. Phytochemistry 62:1221–1224

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Faculty of Biosciences and Aquaculture, University of Nordland, Post Office Box 1490, 8049, Bodø, Norway

    Ioannis N Vatsos

  2. Bioforsk, Norwegian Institute for Agricultural and Environmental Research, Frederik A. Dahlsvei 20, 1430, Ås, Norway

    Celine Rebours

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  1. Ioannis N Vatsos
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  2. Celine Rebours
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Correspondence to Ioannis N Vatsos.

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Vatsos, I.N., Rebours, C. Seaweed extracts as antimicrobial agents in aquaculture. J Appl Phycol 27, 2017–2035 (2015). https://doi.org/10.1007/s10811-014-0506-0

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  • DOI: https://doi.org/10.1007/s10811-014-0506-0

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