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Polymer-free nanocomposite from zeolite and acetylene carbon black as glassy carbon modifier platform for simultaneous electrochemical quantification of acetaminophen and caffeine

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Abstract

Nanocomposite nanozeolite/acetylene carbon black was prepared by combining a type A zeolite with acetylene carbon black (AcB) and used to modify glassy carbon electrode (GCE) without polymer. The zeolite was prepared by hydrothermal method using natural kaolin. The physicochemical characterization of the composite showed a well-integrated composite in which the cubic crystal of the zeolite A and the graphitic aggregate of the carbon black were maintained. The electrochemical impedance spectroscopy study revealed that the composite film GCE (ZA-AcB/GCE) prepared by drop coating displayed a higher kinetic charge transfer compared to pristine zeolite modified GCE (ZA/GCE) and bare GCE. ZA-AcB/GCE, ZA/GCE and GCE were subsequently used to investigate the electrochemical behaviour of acetaminophen (AC) in acidic, neutral and alkaline pHs. The results demonstrate a good electrocatalytic property toward AC at composite film GCE in all these electrolytes compared to bare GCE and confirm the dependence of the electrochemical reaction mechanism of AC on the electrolyte’s pHs. Under optimal conditions, ZA-AcB/GCE exhibited higher sensitivity and selectivity toward both analytes taken individually or simultaneously within large concentration range: 0.5–89 µM for AC and 5–99 µM for caffeine (CAF) with the respective limit of detection of 0.38 and 0.82 µM. The developed sensors were applied successfully in the quantification of the both analytes in pharmaceutical tablets.

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Acknowledgements

Financial support from the Royal Society ACBI programme (Grant AQ150029) is gratefully acknowledged

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Authors and Affiliations

  1. Laboratory of Nanomaterial for Sensors and Energy, Faculty of Science, University of Yaounde I, B.P. 812, Yaoundé, Cameroon

    Firmin Parfait Tchoumi & Justin Claude Kemmegne-Mbouguen

  2. Laboratoire d’Electrochimie Analytique Et de Génie des Matériaux, Faculté Des Sciences, Université de Yaoundé I, B.P. 812, Yaoundé, Cameroon

    Firmin Parfait Tchoumi & Emmanuel Ngameni

  3. Laboratory for Bioinspired Materials -BMBT, Institute of Microsystems Engineering IMTEK-Sensors, University of Freiburg, 79110, Freiburg, Germany

    Arnaud Kamdem Tamo

  4. Institute of Inorganic Chemistry, Christian-Albrechts-Universität Zu Kiel, Max-Eyth-Straße 2, 24118, Kiel, Germany

    Giscard Doungmo

  5. Otto-Von-Guericke-University Magdeburg, Chemical Institute Industrial Chemistry, Universitätsplatz 2, 39106, Magdeburg, Germany

    Cyrille Ghislain Fotsop

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  1. Firmin Parfait Tchoumi
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Contributions

F. P. T.: Conceptualization, Formal analysis, Methodology, Investigation, Validation, Writing original draft, Writing-review and editing A. K. T.: Investigation, Formal analysis, Writing-review and editing G. D.: Formal analysis, Investigation, Writing-review and editing C. G. F.: Formal analysis, Investigation, Writing-review and editing J.C.K.-M.: Conceptualization, Resources, Visualization, Writing-review and editing, Project administration, Funding acquisition E.N.: Supervision, Resources, Funding acquisition, Writing-review and editing

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Correspondence to Justin Claude Kemmegne-Mbouguen.

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Tchoumi, F.P., Tamo, A.K., Doungmo, G. et al. Polymer-free nanocomposite from zeolite and acetylene carbon black as glassy carbon modifier platform for simultaneous electrochemical quantification of acetaminophen and caffeine. J Appl Electrochem (2024). https://doi.org/10.1007/s10800-024-02076-1

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