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Application of Co9S8@MoS2 core–shell/rGO nanocomposite as a novel electrocatalyst in preparation of sensor for the determination of metronidazole

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Abstract

This study is the first report on the application of Co9S8@MoS2 core–shell nanoparticles decorated with reduced graphene oxide in the fabrication of an electrochemical sensor. This sensor exhibited great performance in the determination of metronidazole in blood plasma and tablet samples. These nanoparticles were synthesized via a facile and simple preparation method. First, Graphene oxide was synthesized via the Hummer method, and then Co9S8@MoS2 core–shell nanoparticles were synthesized on the surface and edges of the reduced graphene oxide. In this way, the glassy carbon electrode was modified with Co9S8@MoS2/Reduced graphene oxide nanoparticles. The nanocomposites were characterized by X-ray diffraction, transmission electron microscopy, scanning electron microscopy, energy dispersive X-ray, and Fourier transform infrared spectroscopy. The performance of the prepared sensor was studied by hydrodynamic amperometry and cyclic voltammetry techniques. A significant rise in the peak current and a considerable reduction in the overpotential of metronidazole were identified in the prepared sensor compared to the bare glassy carbon electrode. Under optimized conditions, two linear ranges of 0.5–35.0 μM and 35–180 μM and a limit of detection of 0.38 µM were obtained for metronidazole through the hydrodynamic amperometry technique using the proposed sensor. The Co9S8@MoS2/Reduced graphene oxide sensor demonstrated good reproducibility, fast response, and a large specific area.

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Data availability

The datasets generated during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors wish to thank the financial support from the University of Tabriz, Tabriz, Iran.

Funding

The authors received financial support from the University of Tabriz, Tabriz, Iran.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, 51666-16471, Iran

    Nasrin Lotfi, Mir Reza Majidi & Karim Asadpour-Zeynali

  2. Pharmaceutical Analysis Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 51664, Iran

    Karim Asadpour-Zeynali

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  1. Nasrin Lotfi
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  2. Mir Reza Majidi
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N.L. carried out the experiment, wrote the manuscript M.R.M. supervised the project. K.A.Z. supervised the project

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Correspondence to Karim Asadpour-Zeynali.

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Lotfi, N., Majidi, M.R. & Asadpour-Zeynali, K. Application of Co9S8@MoS2 core–shell/rGO nanocomposite as a novel electrocatalyst in preparation of sensor for the determination of metronidazole. J Appl Electrochem 54, 687–702 (2024). https://doi.org/10.1007/s10800-023-01981-1

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