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Electrocatalytic oxidation and amperometric determination of sulfasalazine using bimetal oxide nanoparticles–decorated graphene oxide composite modified glassy carbon electrode at neutral pH

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Abstract

Cube-shaped samarium orthovanadate (SmVO4) nanoparticles were interconnected with a graphene oxide sheet (GOS) using a simple and eco-friendly method to generate a SmVO4@GOS nanocomposite. SmVO4 was characterized using various spectroscopic and microscopic techniques, which confirmed the wrapping of GOS around the SmVO4 nanoparticles. SmVO4@GOS was then used to modify a glassy carbon electrode (GCE), which was evaluated for its electrochemical performance toward the assay of sulfasalazine (SSZ), an antibiotic drug. Cyclic voltammetry and amperometry were both used for the assay of SSZ using the SmVO4@GOS-modified GCE at pH 7. The modified amperometric sensor is more sensitive, with a low detection limit (2.16 nM) and wide linear range of 20 nM–667 μM (Ag/AgCl). The electrochemical oxidation of SSZ was tested with blood serum and urine samples at physiological pH with recoveries in the range 96.1–98.6%. It indicates that the modified electrochemical sensor has good sensitivity and practical applicability toward SSZ detection. In the field of non-enzymatic sensors, SmVO4@GOS/GCE provides a highly promising performance. Therefore, the electrochemical sensors have capacity for extensive analytical applications in biomedical devices.

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Acknowledgements

This work was also funded by the Researchers Supporting Project Number (RSP-2021/266) King Saud University, Riyadh, Saudi Arabia. 

Funding

Financial support was from the Ministry of Science and Technology, MOST 110–2221-E-131–009, Taiwan, and Research Center for Intelligent Medical Devices of Ming Chi University of Technology, Taiwan. This work was also funded by the Researchers Supporting Project Number (RSP-2021/266) King Saud University, Riyadh, Saudi Arabia.

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Authors and Affiliations

  1. Department of Materials Engineering, Ming Chi University of Technology, New Taipei City, 243303, Taiwan

    Umamaheswari Rajaji, Chih-Ping Chen & Ting-Yu Liu

  2. Department of Chemistry, New Horizon College of Engineering, Outer Ring Road, Bangalore, 560103, India

    Raghu M.S.

  3. Department of Chemistry, Faculty of Engineering and Technology, Jain University, Bangalore, 562112, India

    Yogesh Kumar K.

  4. Korea University of Technology and Education, Cheonan-si 31253, Chungcheongnam-do, Cheonan-si, Republic of Korea

    Yogesh Kumar K.

  5. Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia

    Abdullah A. Al-Kahtani

  6. Department of Chemical and Materials Engineering, Chang Gung University, 259 Wenhua First Road Guishan, Taoyuan, 33302, Taiwan

    Ruey-Shin Juang

  7. Division of Nephrology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan

    Ruey-Shin Juang

  8. Department of Safety, Health and Environmental Engineering, Ming Chi University of Technology, Taishan, New Taipei City, 243303, Taiwan

    Ruey-Shin Juang

  9. Research Center for Intelligent Medical Devices, Center for Plasma and Thin Film Technologies, Ming Chi University of Technology, New Taipei City, 243303, Taiwan

    Ting-Yu Liu

  10. Department of Chemical Engineering and Materials Science, Yuan Ze University, Taoyuan City, 32003, Taiwan

    Ting-Yu Liu

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Rajaji, U., M.S., R., K., Y.K. et al. Electrocatalytic oxidation and amperometric determination of sulfasalazine using bimetal oxide nanoparticles–decorated graphene oxide composite modified glassy carbon electrode at neutral pH. Microchim Acta 189, 409 (2022). https://doi.org/10.1007/s00604-022-05498-w

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