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Methamphetamine determination using label-free impedimetric aptasensor based on ceria nanocomposite

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Abstract

Progress of highly sensitive analytical methods for illicit drugs is one of the serious topics in addressing new challenges based on the consumption of these drugs worldwide. Electrochemical aptamer-based sensors have been widely considered as potent analytical tools providing valuable portability, quick response, sensitivity and specificity in addition to lower charge and simplicity. Herein, a novel aptasensor is presented to determine methamphetamine (METH) via electrochemical impedance spectroscopy (EIS). Nanocerium oxide (CeO2NPs) decorated on reduced graphene oxide was fabricated to modify glassy carbon electrode (GCE) for METH determination. EIS using [Fe(CN)6]−3/−4 redox probe was exploited as a precise detection method for METH determination. The proposed label-free aptasensor was able to detect METH from 0.5 to 250 nM (limit of detection of 0.16 nM). The proposed aptasensor exhibits excellent repeatability and selectivity as well as was effectively employed to determine METH in a spiked urine sample.

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Acknowledgements

This work supported by Center of Excellence in Electrochemistry, University of Tehran, and University of Kashan for financial support of this study.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Islamic Republic of Iran

    Laia Anvari & Sayed Mehdi Ghoreishi

  2. Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran

    Laia Anvari, Mohammad Reza Ganjali & Farnoush Faridbod

  3. Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Kamyar Khoshnevisan

  4. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Kamyar Khoshnevisan

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  1. Laia Anvari
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  2. Sayed Mehdi Ghoreishi
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  3. Kamyar Khoshnevisan
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  4. Mohammad Reza Ganjali
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  5. Farnoush Faridbod
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Contributions

LA: Conceptualization, methodology, writing, original draft preparation, and table preparation. SMG: methodology, Supervision, writing, original draft preparation. KK: methodology, writing, original draft preparation, table and figure preparation, and review. MRG: supervision, writing, original draft preparation. FF: methodology, supervision, writing, original draft preparation

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Correspondence to Sayed Mehdi Ghoreishi or Kamyar Khoshnevisan.

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Anvari, L., Ghoreishi, S.M., Khoshnevisan, K. et al. Methamphetamine determination using label-free impedimetric aptasensor based on ceria nanocomposite. J Appl Electrochem 53, 1843–1851 (2023). https://doi.org/10.1007/s10800-023-01880-5

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  • DOI: https://doi.org/10.1007/s10800-023-01880-5

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