Abstract
Purpose
To compare anti-vascular endothelial growth factor (anti-VEGF) treatment in pachychoroid neovasculopathy (PNV) and age related macular degeneration (AMD).
Methods
Cases having pro re nata (PRN) anti-VEGF treatment for choroidal neovascularization were reviewed and grouped as PNV and AMD. Groups were compared according to central foveal thickness (CFT), best corrected visual acuity (BCVA), and total injection over 12 months. The correlation of beginning choroidal thickness, CFT, and BCVA with final BCVA was analyzed.
Results
Forty-seven PNV and 65 AMD cases were reviewed. Both the PNV group (p = 0.0001) and the AMD group (p = 0.003) had a significant improvement in BCVA and a significant decrease in CFT (p = 0.0001). However, BCVA was better at the 3-, 6-, and 12-month follow-up in PNV (p = 0.003, 0.002, 0.02). No significant CFT difference was observed between groups. The total number of injections was 5.7 ± 1.7 for PNV and 5.2 ± 1.5 for AMD (p = 0.09). Beginning BCVA was positively correlated with final BCVA in both groups.
Conclusion
The PRN treatment regimen was effective for PNV and AMD in terms of visual and anatomical outcomes. Visual response was better in PNV with PRN treatment with the same number of injections.
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All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by GÜ, DH, NÜ, and ÖC. The first draft of the manuscript was written by GÜ and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript. Conceptualization: GÜ, DH; Methodology: GÜ; Formal analysis and investigation: GÜ; Writing-original draft preparation: GÜ, ÖC, NÜ; Writing-review and editing: GÜ, NÜ; Resources: ÖC; Supervision: NÜ.
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This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the University of Health Sciences, Ankara Training and Research Hospital (Date 11.10.2023, No. E-23-1382).
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Üney, G., Hazırolan, D., Ünlü, N. et al. Pro re nata anti-VEGF treatment in pachychoroid neovasculopathy compared with age-related macular degeneration based on optical coherence tomography. Int Ophthalmol 44, 164 (2024). https://doi.org/10.1007/s10792-024-03094-w
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DOI: https://doi.org/10.1007/s10792-024-03094-w