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The diagnostic value of 123I-IMP SPECT in ocular adnexal lymphoma

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Abstract

Background

N-isopropyl- (123I) p-iodoamphetamine (123I-IMP) is specifically accumulated in primary central nervous system lymphoma (PCNSL) during single-photon emission tomography (SPECT) and contributes to its diagnostic imaging. However, whether 123I-IMP is accumulated in ocular adnexal lymphoma (OAL), one of the malignant intraorbital tumors, remains unclear. This study aimed to evaluate the diagnostic value of 123I-IMP SPECT in OAL.

Methods

Between August 2005 and June 2020, 26 patients with intraorbital tumors underwent neurosurgery at the tertiary care center. Of these, 15 patients who underwent 123I-IMPSPECT before surgery were retrospectively examined. The region of interest was set in the cerebellum ipsilateral to the intraorbital tumor on 123I-IMP SPECT, and the tumor-to-cerebellum ratio (T/C ratio) was calculated using the following formula: T/C ratio = [accumulation of tumor (count/pixel)]/[accumulation of ipsilateral normal cerebellar hemisphere (count/pixel)].

Results

Six patients were included in the OAL group, who were pathologically diagnosed with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), diffuse large B-cell lymphoma (DLBCL), and plasmacytoma. The T/C ratio in the OAL group was statistically higher than that in the non-OAL group (p < 0.01). The optimal cutoff values for both groups were between 0.76 and < 0.93. The sensitivity and specificity were 1.00, respectively.

Conclusions

123I-IMP SPECT is useful as one of the examinations in the differential diagnoses of OAL, because it showed a significantly higher accumulation in OAL group than in non-OAL group.

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Acknowledgements

The authors thank RT. Koji Sekiguchi, RT. Takuya Kitamura and RT. Kazuhiro Tachiki of The Radiological Center of Toho University omori medical center for excellent technical assistance, and PhD Chiaki Nishimura, Professor Emeritus of Toho University for helping us with the statistical processing.

Funding

The authors received no specific funding for this work.

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Authors and Affiliations

  1. Department of Neurosurgery (Omori), Faculty of Medicine, School of Medicine, Toho University, 6-11-1, Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan

    Naoyuki Harada, Kosuke Kondo, Sayaka Terazono, Kei Uchino, Yutaka Fuchinoue & Nobuo Sugo

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  1. Naoyuki Harada
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  2. Kosuke Kondo
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  3. Sayaka Terazono
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  4. Kei Uchino
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  5. Yutaka Fuchinoue
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  6. Nobuo Sugo
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Contributions

Naoyuki Harada involved in data analysis, data acquisition, statistical analysis, writing the article. Kosuke Kondo (equal contribution) involved in data acquisition, preparation of figures and tables, writing the article. Sayaka Terazono participated in reviewing the article, surgery and treatment management. Kei Uchino involved in reviewing the article, surgery and treatment management. Yutaka Fuchinoue involved in data acquisition, surgery and treatment management. Nobuo Sugo participated in writing the article, data acquisition, supervision.

Corresponding author

Correspondence to Nobuo Sugo.

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Consent to Participate

This study was approved by the ethics committee of the Toho University Omori Medical Center (approval number: M20185). Consent to participate was obtained as an opt-out.

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This study was approved by the ethics committee of Toho University Omori Medical Center (approval number, M20185). Consent to publish was obtained as an opt-out.

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Harada, N., Kondo, K., Terazono, S. et al. The diagnostic value of 123I-IMP SPECT in ocular adnexal lymphoma. Int Ophthalmol 42, 1205–1212 (2022). https://doi.org/10.1007/s10792-021-02105-4

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