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Histopathological and ophthalmoscopic evaluation of apocynin on experimental proliferative vitreoretinopathy in rabbit eyes

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Abstract

The aim of the current study was to evaluate the effect of apocynin (APO) on the development of proliferative vitreoretinopathy (PVR). New Zealand-type male rabbits were randomly grouped into three as follows: (1) Sham group rabbits which were applied intraperitoneal (i.p.) vehicle without PVR; (2) PVR group rabbits where PVR was created and an i.p. vehicle was administered for 21 successive days; (3) PVR + APO group rabbits where PVR was created and i.p. APO was administered for 21 successive days. Fundus examination was conducted with an indirect ophthalmoscope before starting the experiments and at each visit afterwards. At the end of the work, the rabbits were sacrificed under high-dose anesthesia and then eye tissues were taken for histopathological analyses. In the PVR + APO group, histopathologic and ophthalmoscopic examination revealed significant decrease in PVR formation. As the result, it has been observed that APO at least partially inhibits PVR formation.

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Authors and Affiliations

  1. Department of Ophthalmology, Medical Faculty, Giresun University, Giresun, Turkey

    Murat Atabey Ozer & Serkan Ozen

  2. Department of Ophthalmolohy, Medical Faculty, Inonu University, Malatya, Turkey

    Nihat Polat

  3. Department of Ophthalmolohy, Medical Faculty, Kirikkale University, Kirikkale, Turkey

    Tevfik Ogurel

  4. Department of Pharmacology, Medical Faculty, Inonu University, Malatya, Turkey

    Hakan Parlakpinar

  5. Department of Histology and Embryology, Medical Faculty, Inonu University, Malatya, Turkey

    Nigar Vardi

Authors
  1. Murat Atabey Ozer
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  2. Nihat Polat
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  3. Serkan Ozen
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  4. Tevfik Ogurel
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  5. Hakan Parlakpinar
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  6. Nigar Vardi
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Correspondence to Murat Atabey Ozer.

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Ozer, M.A., Polat, N., Ozen, S. et al. Histopathological and ophthalmoscopic evaluation of apocynin on experimental proliferative vitreoretinopathy in rabbit eyes. Int Ophthalmol 37, 599–605 (2017). https://doi.org/10.1007/s10792-016-0318-0

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  • DOI: https://doi.org/10.1007/s10792-016-0318-0

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