Abstract
The aim of this study was to evaluate the central retinal thickness (CRT), outer nuclear layer thickness (ONLT), photoreceptor layer thickness (PLT), photoreceptor layer integrity, and the correlation between visual acuity and PLT in eyes with branch retinal vein occlusion (BRVO) 2 months after treatment with intravitreal dexamethasone implant (Ozurdex; Allergan, Inc, Irvine, CA). In this prospective study, 32 eyes of 32 patients were enrolled. A single injection of Ozurdex was administered to all the patients. CRT, ONLT, and PLT were measured using spectral-domain optical coherence tomography before and 2 months after the injection. Best-corrected visual acuity (BCVA [logMAR]) and photoreceptor cell integrity were also evaluated. The average CRT, ONLT, PLT, and BCVA values for the sample group before the treatment were as follows: 707 ± 261, 608 ± 288, 70 ± 25, and 0.96 ± 0.22 µm, respectively. The average CRT, ONLT, PLT, and BCVA values for the sample group 2 months after the Ozurdex injection were as follows: 299 ± 149, 211 ± 138, 77 ± 20, and 0.63 ± 0.30 µm, respectively (p < 0.05). Two months after the Ozurdex injection, BCVA correlated with ONLT and PLT (r = 0.365, p = 0.048 and r = −0.488, p = 0.021, respectively), whereas BCVA was not correlated with CRT (r = 0.239, p = 0.189). Photoreceptor layer is associated with the visual function of eyes with macular edema secondary to BRVO. Also, ONLT seems to be more closely related to visual acuity improvement than CRT decrement.
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Yau JW, Lee P, Wong TY, Best J, Jenkins A (2008) Retinal vein occlusion: an approach to diagnosis, systemic risk factors and management. Intern Med J 38:904–910
Rogers S, McIntosh RL, Cheung N, Lim L, Wang JJ, Mitchell P et al (2010) The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia and Australia. Ophthalmology 117:313–319
Haller JA, Bandello F, Belfort R Jr, Blumenkranz MS, Gillies M, Heier J et al (2010) Randomized sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. Opthalmology 117:1134–1146
Funatsu H, Yamashita H, Noma H, Mimura T, Yamashita T, Hori S (2002) Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humor of diabetics with macular edema. Am J Ophthalmol 133:70–77
Patel JI, Tombran-Tink J, Hykin PG, Gregor ZJ, Cree IA (2006) Vitreous and aqueous concentrations of proangiogenic, antiangiogenic factors and other cytokines in diabetic retinopathy patients with macular edema: implications for structural differences in macular profiles. Exp Eye Res 82:798–806
Feltgen N, Pielen A, Hansen L, Bertram B, Agostini H, Jaissle GB et al (2010) Intravitreal drug therapy for retinal vein occlusion pathophysiological mechanisms and routinely used drugs. Klin Monbl Augenheilkd 227:681–693
Koss MJ, Naser H, Sener A, Ackermann H, Al-Sarireh F, Singh P et al (2010) Combination therapy in diabetic macular edema and retinal vein occlusion—past and present. Acta Ophthalmol 90:580–589
Ritch R, Prata TS, de Moraes CG, Vessani RM, Costa VP, Konstas AG et al (2010) Association of exfoliation syndrome and central retinal vein occlusion: an ultra-structural analysis. Acta Ophthalmol 88:91–95
Higashiyama T, Sawada O, Kakinoki M, Sawada T, Kawamura H, Ohji M (2013) Prospective comparisons of intravitreal injections of triamcinolone acetonide and bevacizumab for macular edema due to branch retinal vein occlusion. Acta Ophthalmol 91:318–324
Puche N, Glacet A, Mimoun G, Zourdani A, Coscas G, Soubrane G (2012) Intravitreal ranibizumab for macular edema secondary to retinal vein occlusion: a retrospective study of 34 eyes. Acta Ophthalmol 90:357–361
Chang-Lin JE, Attar M, Acheampong AA, Robinson MR, Whitcup SM, Kuppermann BD et al (2011) Pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone intravitreal implant. Invest Ophthalmol Vis Sci 52:80–86
Health Quality Ontario (2009) Optical coherence tomography for age-related macular degeneration and diabetic macular edema: an evidence-based analysis. Ont Health Technol Assess Ser 9:1–22
Matsumoto H, Sato T, Kishi S (2009) Outer nuclear layer thickness at the fovea determines visual outcomes in resolved central serous chorioretinopathy. Am J Ophthalmol 148:105–110
Haller J, Bandello F, Belfort R Jr, Blumenkranz MS, Gillies M, Heier J et al (2010) OZURDEX GENEVA Study Group: randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. Ophthalmology 117:1134–1146
Haller JA, Bandello F, Belfort R Jr, Blumenkranz MS, Gillies M, Heier J et al (2011) Ozurdex GENEVA Study Group; Li J: dexametha sone intravitreal implant in patients with macular edema related to branch or central retinal vein occlusion twelve-month study results. Ophthalmology 118:2453–2460
Kuppermann BD, Blumenkranz MS, Haller JA, Williams GA, Weinberg DV, Chou C et al (2007) Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema. Arch Ophthalmol 125:309–317
Querques L, Querques G, Lattanzio R, Gigante SR, Del Turco C, Corradetti G et al (2013) Repeated intravitreal dexamethasone implant (Ozurdex) for retinal vein occlusion. Ophthalmologica 229:21–25
Tso MOM (1982) Pathology of cystoid macular edema. Ophthalmology 89:902–915
Akagi-Kurashige Y, Tsujikawa A, Ooto S, Makiyama Y, Muraoka Y, Kumagai K et al (2014) Retinal microstructural changes in eyes with resolved branch retinal vein occlusion: an adaptive optics scanning laser ophthalmoscopy study. Am J Ophthalmol 157:1239–1249
Ota M, Tsujikawa A, Murakami T, Yamaike N, Sakamoto A, Kotera Y et al (2008) Foveal phototoreceptor layer in eyes with persistent cystoid macular edema associated with branch retinal vein occlusion. Am J Ophthalmol 145:273–280
Ota M, Tsujikawa A, Kita M, Miyamoto K, Sakamoto A, Yamaike N et al (2008) Integrity of foveal photoreceptor layer in central retinal vein occlusion. Retina 28:1502–1508
Ota M, Tsujikawa A, Murakami T, Kita M, Miyamoto K, Sakamoto A et al (2007) Association between integrity of foveal photoreceptor layer and visual acuity in branch retinal vein occlusion. Br J Ophthalmol 91:1644–1649
Piccolino FC, de la Longrais RR, Ravera G, Eandi CM, Ventre L, Abdollahi A et al (2005) The foveal photoreceptor layer and visual acuity loss in central serous chorioretinopathy. Am J Ophthalmol 139:87–99
Witkin AJ, Ko TH, Fujimoto JG, Chan A, Drexler W, Schuman JS et al (2006) Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases. Am J Ophthalmol 142:945–952
Ergun E, Hermann B, Wirtitsch M, Unterhuber A, Ko TH, Sattmann H et al (2005) Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultra-high resolution optical coherence tomography. Invest Ophthalmol Vis Sci 46:310–316
Villate N, Lee JE, Venkatraman A, Smiddy WE (2005) Photoreceptor layer features in eyes with closed macular holes: optical coherence tomography findings and correlation with visual outcomes. Am J Ophthalmol 139:280–289
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Altunel, O., Duru, N., Goktas, A. et al. Evaluation of foveal photoreceptor layer in eyes with macular edema associated with branch retinal vein occlusion after ozurdex treatment. Int Ophthalmol 37, 333–339 (2017). https://doi.org/10.1007/s10792-016-0261-0
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DOI: https://doi.org/10.1007/s10792-016-0261-0