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The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled study

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Abstract

Through modulating effects on the gut-brain axis, probiotics are an effective adjuvant treatment for Alzheimer’s disease (AD), one of our century’s most important medical care challenges (Agahi et al. Front Neurol 9:662, 2018). This trial aimed to examine the effects of two different single-strain probiotics on oxidative stress and inflammation in patients with mild and moderate AD. This was a 12-week placebo-controlled, double-blind, randomized clinical trial performed on 90 patients with AD. Eligible patients were randomly assigned to two different interventions (Lacticaseibacillus rhamnosus HA-114 (7.5 × 109) or Bifidobacterium longum R0175 (7.5 × 109)) and a placebo group, supplemented twice daily. We used mixed-effect models to examine the probiotic’s independent effects on clinical results. Significant improvements in serum inflammatory and oxidative stress markers were observed at the end of the trial (P < 0.05). Probiotic supplementation for 12 weeks had beneficial effects on oxidative stress, inflammation, quality of life, and physical activity in patients with mild and moderate AD.

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All the data produced or examined during the research are included in this article. For additional information, please contact the corresponding author.

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Acknowledgements

This research was supported by a grant from Tehran University of Medical Science. The authors appreciate all participants and the staff of Ziaeeian, Roozbeh and Shariati Hospital.

Funding

This study did not receive any funding from public, commercial, or not-for-profit entities.

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Authors and Affiliations

  1. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

    Camellia Akhgarjand & Kurosh Djafarian

  2. Cognitive Neurology and Neuropsychiatry Division, Psychiatry Department, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Zahra Vahabi

  3. Geriatric Department, Ziaeeian Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Zahra Vahabi

  4. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

    Sakineh Shab-Bidar

  5. Department of Internal Medicine, School of Medicine, Firoozgar General Hospital, Iran University of Medical Science, Tehran, Iran

    Aliarash Anoushirvani

Authors
  1. Camellia Akhgarjand
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  2. Zahra Vahabi
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  3. Sakineh Shab-Bidar
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  4. Aliarash Anoushirvani
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  5. Kurosh Djafarian
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Contributions

KD takes responsibility for the accuracy and integrity of the research. CA and ZV were responsible for composing the manuscript, while SSB and CA gathered the data. SSB reviewed and revised the manuscript.

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Correspondence to Zahra Vahabi or Kurosh Djafarian.

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Akhgarjand, C., Vahabi, Z., Shab-Bidar, S. et al. The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled study. Inflammopharmacol 32, 1413–1420 (2024). https://doi.org/10.1007/s10787-023-01427-2

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