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Dynamin-related protein-1 as potential therapeutic target in various diseases

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Abstract

Mitochondria can interchange morphology due to their dynamic nature. It can exist in either fragmented disconnected arrangement or elongated interconnected mitochondrial networks due to fission and fusion, respectively. The recent studies have revealed the remarkable and unexpected insights into the physiological impact and molecular regulation of mitochondrial morphology. The balance between fission and fusion governs the faith of the cell. The active targeting of DRP 1 to the outer mitochondrial membrane (OMM) is done by non-GTPase receptor proteins such as mitochondrial fission factor, mitochondrial fission protein 1 and mitochondrial elongation factor 1. The active targeting of DRP 1 to OMM leads to the fission of mitochondria. However, the imbalance of DRP 1-dependent mitochondrial fission and modulation of equilibrium of fission and fusion has been documented to be involved in several cardiovascular and neurodegenerative disorders. In this review, we are focusing on the active participation of DRP 1 in various diseases and also the factors responsible for the activation of DRP 1 for its action.

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Abbreviations

DRP 1:

Dynamin-related protein 1

ROS:

Reactive oxygen species

MFF:

Mitochondrial fission factor

FIS1:

Fission protein 1

PINK1:

PTEN-induced putative kinase 1

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  1. Cardiovascular Division, Department of Pharmacology, I.S.F. College of Pharmacy, Moga, 142001, Punjab, India

    Surinder Singh & Saurabh Sharma

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  1. Surinder Singh
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Singh, S., Sharma, S. Dynamin-related protein-1 as potential therapeutic target in various diseases. Inflammopharmacol 25, 383–392 (2017). https://doi.org/10.1007/s10787-017-0347-y

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