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Periodontal Disease Impairs Muscle Recovery by Modulating the Recruitment of Leukocytes

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A Correction to this article was published on 11 September 2020

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Abstract

The purpose of this study is to analyze the impact of periodontal disease (PD) associated with physical exercise on inflammatory mediators and muscle repair. Twenty-four Wistar rats were divided into four groups: control (SH), healthy trained (TH), sedentary with PD (SP), and trained with PD (TP). PD was induced in groups SP and TP while the trained groups performed treadmill exercises for 8 weeks. For the analysis of IL-6, IL-10, TNF-α, and leukocyte count, we collected blood samples. Cryolesions were induced in the tibialis anterior and gastrocnemius, which were analyzed for morphological changes. The presence of PD modified leukocyte counts, while exercise showed an additive role. PD increased levels of IL-6, IL-10, and TNF-α, and physical exercise changed only values of IL-10. The association between physical exercise and PD was responsible for an increased concentration of leukocytes in the region of the inflammation. Serum levels of inflammatory markers were modified by PD and, when combined with exercise, may negatively modulate inflammation. The association between PD and physical exercise showed the most significant changes in the number of inflammatory cells and may negatively influence the process of muscle repair.

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  • 11 September 2020

    The original version of this article contained mistakes, and the authors would like to correct them.

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Authors and Affiliations

  1. Dentistry School, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

    Bárbara Capitanio de Souza, Bibiana Franzen Matte & Marcelo Lazzaron Lamers

  2. Laboratory of Exercise Research (LAPEX), College of Physical Education (ESEF), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

    André Luiz Lopes & Bruno Costa Teixeira

  3. Department of Morphological Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

    Marcelo Lazzaron Lamers

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  1. Bárbara Capitanio de Souza
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Correspondence to Bárbara Capitanio de Souza.

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The original version of this article was revised: The production made a mistake in the article title where the word “Periodontal” was changed to “Periodical”.

Electronic supplementary material

Supplemental Fig. 1

Replacing the thymic parenchyma by adipose tissue. V=Pp/Ptx100% formula was used to calculate the volumetric density of adipose tissue present in the thymic parenchyma, where Pp is the number of points Pt on fat cells and the number of points of the test system (A). SH: control, SP: sedentary with periodontal disease, TH: trained without periodontal disease, TP: trained with periodontal disease. Hematoxylin-eosin staining. 200X magnification (JPG 310 kb)

Supplemental Fig. 2

Test system for analysis of inflammatory intensity. V=Pp/Ptx100% formula was used to calculate the volumetric density of inflammatory cells, where Pp is the number of points on Pt inflammatory cells and the number of points of the test system. Hematoxylin-eosin staining. 400X magnification (JPG 148 kb)

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de Souza, B.C., Matte, B.F., Lopes, A.L. et al. Periodontal Disease Impairs Muscle Recovery by Modulating the Recruitment of Leukocytes . Inflammation 43, 382–391 (2020). https://doi.org/10.1007/s10753-019-01128-5

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