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Umbelliferone Alleviates Myocardial Ischemia: the Role of Inflammation and Apoptosis

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Abstract

The present study was to investigate cardioprotective effects of umbelliferone (Umb) on coronary artery ligation-induced myocardial ischemia. The model of myocardial ischemia (MI) was induced by ligatured the left anterior descending coronary artery of SD rats. ST-segment elevation, lactate dehydrogenase (LDH), creatine kinase (CK), catalase (SOD), malondialdehyde (MDA), inflammatory cytokines, Toll-like receptors (TLRs)/nuclear factor (NF)-κBp65 pathway, and apoptosis were evaluated in rats treated with or without Umb. The results showed that Umb treatment could significantly decrease the elevation of the ST segment of electrocardiograph (ECG), the myocardial infarct size of MI significantly. The levels of LDH, CK, and MDA were suppressed, and the content of SOD was enhanced with Umb. The elevated concentration of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and IL-6 in MI rats was effectively reversed by the Umb administration. Also, TLR/NF-κB and apoptosis-related proteins in MI rats were restored respectively by Umb treatment. The protective effect of Umb against MI injury might be associated with inflammation and apoptosis pathway.

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Authors and Affiliations

  1. Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210000, China

    Jianxiang Gan, Weichun Qian & Song Lin

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  1. Jianxiang Gan
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  2. Weichun Qian
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  3. Song Lin
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Correspondence to Song Lin.

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All animal procedures were performed in strict accordance to the Institutional Animal Research Committee guidelines and approved by the Animal Ethics Committee of Nanjing University of Chinese Medicine.

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The authors declare that they have no conflict of interest.

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Gan, J., Qian, W. & Lin, S. Umbelliferone Alleviates Myocardial Ischemia: the Role of Inflammation and Apoptosis. Inflammation 41, 464–473 (2018). https://doi.org/10.1007/s10753-017-0702-6

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  • DOI: https://doi.org/10.1007/s10753-017-0702-6

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