Abstract
Takotsubo syndrome (TTS) in the pediatric population is an infrequent but relevant cause of morbidity and mortality, with limited studies addressing its clinical course and prognosis. We aimed to analyze the clinical features and prognosis of pediatric TTS in a nation-wide multicenter registry and considering the published literature. We included a total of 54 patients from 4 different hospitals in Spain, as well as pediatric TTS patients from the published literature. Comparisons between groups were performed in order to assess for statistically and clinically relevant prognostic differences between pediatric and adult population features. Patients with pediatric TTS are more commonly male and exhibit a higher prevalence of physical triggers. The left ventricular ejection fraction (LVEF) was significantly lower in the pediatric population (30.5 + 10.4 vs 36.9 + 16.9, p < 0.05), resulting in more than fivefold rates of cardiogenic shock on admission compared to the general adult TTS population (Killip IV 74.1% vs 10.5%, p < 0.001) with similar rates of death and recurrence between groups. TTS in the pediatric population presents a distinctive clinical profile, with higher prevalence of atypical symptoms and physical triggers, as well as higher rates of cardiogenic shock on admission and similar mortality and recurrence rates than those of the adult population. This study provides valuable insights into understanding pediatric TTS and underscores the necessity for further research in this age group.
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Change history
16 April 2024
A Correction to this paper has been published: https://doi.org/10.1007/s10741-024-10401-1
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No funding was required for the preparation of this manuscript. The web page from the RETAKO registry has been funded with the help of a non-conditioned grant from FIC (Fundación Investigación Cardiovascular).
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RV and IN created the idea and the original manuscript, MR, AC, and OV contributed with cases, and MA, AU, MC, FA, EB, CL, CF, and MA reviewed the manuscript and revised the literature.
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The study complied with the Declaration of Helsinki and was approved by the Institutional Ethics Committee of the RETAKO coordinator center [19]. All patients provided informed consent.
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Vazirani, R., Rodríguez-González, M., Castellano-Martinez, A. et al. Pediatric takotsubo cardiomyopathy: A review and insights from a National Multicentric Registry. Heart Fail Rev (2024). https://doi.org/10.1007/s10741-024-10394-x
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DOI: https://doi.org/10.1007/s10741-024-10394-x