Abstract
Polyteny is an effective mechanism for accelerating growth and enhancing gene expression in eukaryotes. The purpose of investigation was to study the genetic variability of polyteny degree of giant chromosomes in the salivary glands of Drosophila melanogaster Meig. in relation to the differential fitness of different genotypes. 16 strains, lines and hybrids of fruit flies were studied. This study demonstrates the significant influence of hereditary factors on the level of polytenization of giant chromosomes in Drosophila. This is manifested in the differences between strains and lines, the effect of inbreeding, chromosome isogenization, hybridization, adaptively significant selection, sexual differences, and varying degrees of individual variability of a trait in different strains, lines, and hybrids. The genetic component in the variability of the degree of chromosome polyteny in Drosophila salivary glands was 45.3%, the effect of sex was 9.5%. It has been shown that genetic distances during inbreeding, outbreeding or hybridization, which largely determine the selective value of different genotypes, also affect polyteny patterns. Genetic, humoral, and epigenetic aspects of endocycle regulation, which may underlie the variations in the degree of chromosome polyteny, as well as the biological significance of the phenomenon of endopolyploidy, are discussed.
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Abbreviations
- C V :
-
Coefficient of variation
- ES:
-
Ecdysterone
- HSP:
-
Heat shock proteins
- IIS:
-
Insulin/insulin-like growth factor
- JH:
-
Juvenile hormone
- SSD:
-
Sexual size dimorphism
- EGFR/MAPK:
-
Epidermal growth factor receptor/mitogen-activated protein kinase
- Hpo/Yki:
-
Hippo/Yorkie
- JAK/STAT:
-
Janus kinases/signal transducer and activator of transcription proteins
- JNK:
-
C-Jun N-terminal kinases
- PI3K/TOR:
-
Phosphoinositide-3-kinase/target of rapamycin
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This work was supported by the Ministry of Education and Science of Ukraine (Project State Registration Number: 0117U004836).
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Strashnyuk, V.Y., Shakina, L.A. & Skorobagatko, D.A. Variability of polyteny of giant chromosomes in Drosophila melanogaster salivary glands. Genetica 151, 75–86 (2023). https://doi.org/10.1007/s10709-022-00168-4
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DOI: https://doi.org/10.1007/s10709-022-00168-4