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Assessing oxidative stress resulting from environmental exposure to metals (Oids) in a middle Eastern population

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Abstract

Concentrations of metals and metalloids derived mainly from anthropogenic activities have increased considerably in the environment. Metals might be associated with increase reactive oxygen species (ROS) damage, potentially related to several health outcomes. This study has recruited 200 adult participants, including 110 males and 90 females in Shiraz (Iran), to investigate the relationship between chronic exposure to metals and ROS damage by analyzing malondialdehyde (MDA) and 8-Oxo-2'-deoxyguanosine (8-OHdG) concentrations, and has evaluated the associations between chronic metal exposure and ROS damage using regression analysis. Our findings showed participants are chronically exposed to elevate As, Ni, Hg, and Pb levels. The mean urinary concentrations of 8-OHdG and MDA were 3.8 ± 2.35 and 214 ± 134 µg/g creatinine, respectively. This study shows that most heavy metals are correlated with urinary ROS biomarkers (R ranges 0.19 to 0.64). In addition, regression analysis accounting for other confounding factors such as sex, age, smoking status, and teeth filling with amalgam highlights that Al, Cu, Si and Sn are associated with 8-OHdG concentrations, while an association between Cr and MDA and 8-OHdG is suggested. Smoking cigarettes and water-pipe is considered a significant contributory factor for both ROS biomarkers (MDA and 8-OHdG).

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Funding

The present study was financially supported by the Shiraz University of Medical Sciences (grant no.17569). Authors thank all the subjects who took part in this study.

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Authors and Affiliations

  1. Department of Medicine, University of Alberta, Edmonton, AB, Canada

    Ata Rafiee

  2. Perinatal Epidemiology, Environmental Health and Clinical Research, School of Medicine, Universitat Jaume I, Castellon, Spain

    Juana Maria Delgado-Saborit

  3. ISGlobal Barcelona Institute for Global Health, Barcelona Biomedical Research Park, Barcelona, Spain

    Juana Maria Delgado-Saborit

  4. Population Health and Environmental Sciences, Analytical Environmental and Forensic Sciences, King’s College London, London, UK

    Juana Maria Delgado-Saborit

  5. Division of Environmental Health & Risk Management, School of Geography, Earth & Environmental Sciences, University of Birmingham, Birmingham, UK

    Juana Maria Delgado-Saborit

  6. Department of Chemistry, University of Malta, Msida, 2080, MSD, Malta

    Noel J. Aquilina

  7. Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran

    Hoda Amiri

  8. Research Center for Health Sciences, Institute of Health, Department of Environmental Health Engineering, School of Public Health, Shiraz University of Medical Sciences, Razi blvd, Kuye Zahra Street, Shiraz, Iran

    Mohammad Hoseini

Authors
  1. Ata Rafiee
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  2. Juana Maria Delgado-Saborit
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  3. Noel J. Aquilina
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  4. Hoda Amiri
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  5. Mohammad Hoseini
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Contributions

AR: Conceptualization, Methodology development, Formal Analysis, Writing-Original draft preparation, Reviewing and Editing. JMD-S: Writing-Reviewing and Editing. NJA: Writing. HA: Data curation. MH: Funding acquisition and Project administration.

Corresponding author

Correspondence to Mohammad Hoseini.

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Conflict of Interest

Authors declare they do not have any competing financial interests in relation to this study.

Ethics approval

The Ethical Committee approved the present study at the Shiraz University of Medical Sciences (IR.SUMS.REC.1398.320).

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All subjects were informed about study’s objectives and gave written consent to participate in this study.

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Rafiee, A., Delgado-Saborit, J.M., Aquilina, N.J. et al. Assessing oxidative stress resulting from environmental exposure to metals (Oids) in a middle Eastern population. Environ Geochem Health 44, 2649–2668 (2022). https://doi.org/10.1007/s10653-021-01065-z

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  • DOI: https://doi.org/10.1007/s10653-021-01065-z

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