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Role of Serology, Dietary Assessment, and Fecal Gluten Immunogenic Peptides for Predicting Histologic Recovery in Children with Celiac Disease

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Abstract

Background

A strict lifelong gluten-free diet (GFD) remains the only treatment of celiac disease (CD). Adherence to gluten-free diet is best reflected by mucosal healing. Noninvasive tools capable of predicting mucosal recovery in CD patients need to be identified.

Aims

To compare the ability of various modalities used to assess compliance to GFD, for predicting persistent mucosal damage in children with CD.

Methods

A prospective, single-center, observational study on children with CD on a GFD was conducted between January 2020 and April 2021. Children with CD on GFD were consecutively enrolled and various modalities used to assess adherence to GFD were compared.

Results

One hundred and fifty children (Mean age 12.2 ± 3.6 years, 58% Boys) on GFD (Mean duration 6 ± 3.1 years) were enrolled in the study. Persistent mucosal damage was seen in 88% of the enrolled. Fecal gluten immunogenic peptide (GIP) was positive in 87.8% (129/147). Antibodies to tissue transglutaminase (TGA-IgA) and/or deamidated gliadin peptide (DGP) were positive in 32% (48/150) whereas antibody to synthetic neoepitopes of TGA-IgA was positive in 24.8% (37/149). Non-compliance as assessed by local questionnaire, Biagi score, and dietitian detailed interview were 62.7%, 60%, and 75.3%, respectively. Serology had the highest specificity (83%) and fecal GIP had the highest sensitivity (89%). On logistic regression analysis, only non-compliance by Biagi score predicted poor mucosal recovery.

Conclusion

Fecal GIP may be sensitive to detect only “one-point dietary transgression.” None of the existing modalities used to assess compliance to GFD accurately predict persistent mucosal damage. A subset of patients may develop gluten tolerance.

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Author notes

  1. Keerthivasan Seetharaman and Sadhna Bhasin Lal are joint first authors.

Authors and Affiliations

  1. Division of Pediatric Gastroenterology and Hepatology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India

    Keerthivasan Seetharaman & Sadhna Bhasin Lal

  2. Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

    Kaushal Kishor Prasad

  3. Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

    Yashwant Kumar

  4. Department of Experimental Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India

    Alka Bhatia

  5. Department of Dietetics, Post Graduate Institute of Medical Education and Research, Chandigarh, India

    Sunita Malhotra

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  1. Keerthivasan Seetharaman
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Seetharaman, K., Lal, S.B., Prasad, K.K. et al. Role of Serology, Dietary Assessment, and Fecal Gluten Immunogenic Peptides for Predicting Histologic Recovery in Children with Celiac Disease. Dig Dis Sci 68, 529–540 (2023). https://doi.org/10.1007/s10620-022-07762-8

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