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Seco-Abietanoids from Cryptomeria japonica and Their Inhibitory Activity Toward Xanthine Oxidase

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Chemistry of Natural Compounds Aims and scope

A new seco-abietanoid, 12-methoxy-7-oxo-6,7-secoabieta-8,11,13-trien-6-oic acid (1), and a known seco-abietanoid,12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (2), were isolated from the methanol extract of the bark of Cryptomeria japonica. Structure determination of the two compounds was accomplished by spectroscopic analyses including 1D and 2D NMR (1H, 13C, COSY, HMQC, HMBC, and NOESY) and EI-MS. At a concentration of 50 μM, the inhibitory effects of compounds 1 and 2 on xanthine oxidase were 30.4 ± 0.9% and 32.0 ± 1.7%, respectively.

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Acknowledgment

This work was financially supported by the China Medical University grant in Taiwan (10959189 and CMU109-AWARD-02) and the “Chinese Medicine Research Center, China Medical University” from the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan (CMRC-CHM-2-1). The authors are grateful to Ms Shu-Yun Sun for the MS measurements in the Instrumentation Center of the College of Science, National Taiwan University and Prof. Yen-Hsueh Tseng for identification of plant material. We are also grateful to the National Center for high-performance computing for computer time and facilities.

Chi-I Chang and Che-Yi Chao contributed equally to this work.

Author information

Authors and Affiliations

  1. Department of Biological Science and Technology, National Pingtung University of Science and Technology, 91201, Pingtung, Taiwan

    Chi-I Chang

  2. Research Center for Active Natural Products Development, National Pingtung University of Science and Technology, 91201, Pingtung, Taiwan

    Chi-I Chang

  3. Department of Chemistry, National Taiwan University, 10617, Taipei, Taiwan

    Cheng-Chi Chen

  4. Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, 80708, Kaohsiung, Taiwan

    Horng-Huey Ko

  5. Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, 11221, Taipei, Taiwan

    Jih-Jung Chen

  6. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), 300, Hsinchu, Taiwan

    Ming-Jen Cheng

  7. Department of Food Nutrition and Health Biotechnology, Asia University, 41354, Taichung, Taiwan

    Che-Yi Chao

  8. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, 40402, Taichung, Taiwan

    Yueh-Hsiung Kuo

  9. Department of Biotechnology, Asia University, 41354, Taichung, Taiwan

    Yueh-Hsiung Kuo

  10. Chinese Medicine Research Center, China Medical University, 40402, Taichung, Taiwan

    Yueh-Hsiung Kuo

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  1. Chi-I Chang
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  2. Cheng-Chi Chen
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  3. Horng-Huey Ko
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  4. Jih-Jung Chen
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  5. Ming-Jen Cheng
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  6. Che-Yi Chao
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  7. Yueh-Hsiung Kuo
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Correspondence to Chi-I Chang.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2022, pp. 410–412.

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Chang, CI., Chen, CC., Ko, HH. et al. Seco-Abietanoids from Cryptomeria japonica and Their Inhibitory Activity Toward Xanthine Oxidase. Chem Nat Compd 58, 478–481 (2022). https://doi.org/10.1007/s10600-022-03714-w

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  • DOI: https://doi.org/10.1007/s10600-022-03714-w

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