6,7-Difluoroquinoxaline (1) reacted with 1- and 2-methylindoles (2a and 2b) with heating in AcOH to give products from substitution of H in the heterocyclic fragment (3a and 3b) and tris(indol-3-yl)methane derivatives (4a and 4b).
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
G. B. Barlin, in: The Chemistry of Heterocyclic Compounds, G. A. Weissberger and E. C. Taylor (eds.), Wiley/Interscience, Chichester, 1982, p. 41.
G. W. N. Cheeseman and R. F. Cookson, in: The Chemistry of Heterocyclic Compounds, G. A. Weissberger and E. C. Taylor (eds.), Wiley/Interscience, New York, 1979, p. 35.
M. D. Mashkovskii, Drugs [in Russian], Part II, Meditsina, Moscow, 1993, 356 pp.
Yu. A. Azev, M. I. Kodess, M. A. Ezhikova, A. M. Gibor, V. I. Baranov, O. S. Ermakova, and V. A. Bakulev, Pharm. Chem. J., 47 (9), 498 (2013).
V. N. Charushin and O. N. Chupakhin, in: Topics in Heterocyclic Chemistry, V. N. Charushin and O. N. Chupakhin (eds.), Springer, Switzerland, 2014, p. 37.
S. N. Lavrenov, Yu. N. Luzikov, E. E. Bykov, M. I. Reznikova, E. V. Stepanova, V. A. Glazunova, Yu. L. Volodina, V. V. Tatarsky, Jr., A. A. Shtil, and M. N. Preobrazhenskaya, Bioorg. Med. Chem., 18, 6905 (2010).
Yu. A. Azev, T. Duelks, E. Lork, and D. Gabel, Mendeleev Commun., 15, 193 (2005).
V. V. Takhistov, Organic Mass Spectrometry [in Russian], Nauka, Leningrad, 1990, 361 pp.
E. V. Stepanova, A. A. Shtil, S. N. Lavrenov, V. M. Bukhman, A. N. Inshakov, E. P. Mirchink, A. S. Trenin, O. A. Galatenko, E. B. Isakova, V. A. Glazunova, L. G. Dezhenkova, E. Sh. Solomko, E. E. Bykov, and M. N. Preobrazhenskaya, Izv. Akad. Nauk, Ser. Khim., 12, 2203 (2010).
I. D. Konstantinova, O. M. Selezneva, I. V. Fateev, T. A. Balashova, S. K. Kotovskaya, Z. M. Baskakova, V. N. Charushin, A. V. Baranovsky, A. I. Miroshnikov, J. Balzrini, and I. A. Mikhailopulo, Synthesis, 45, 272 (2013).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2017, pp. 441–443.
Rights and permissions
About this article
Cite this article
Azev, Y.A., Ermakova, O.S., Ezhikova, M.A. et al. Transformations of 6,7-difluoroquinoxaline with Indoles: Synthesis of Indole-Substituted 6,7-difluoroquinoxalines and Tris(indol-3-yl)methane Derivatives. Chem Nat Compd 53, 519–522 (2017). https://doi.org/10.1007/s10600-017-2036-x
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10600-017-2036-x