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Chemical Constituents of Pittosporum illicioides

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Chemistry of Natural Compounds Aims and scope

3-Oxo-20-demethylisoaleuritolic-14(15)-ene-28,30-dioic acid (1), a novel triterpenoid, has been isolated from the ethanolic extract of Pittosporum illicioides, together with eight known compounds, i.e., stearic acid (2), 6,7-dimethoxycoumarin (3), 7-hydroxy-6-methoxycoumarin (4), 4,4-dimethylheptanedioic acid (5), syringic acid (6), syringaresinol (7), zhebeiresinol (8), and hacquetiasaponin 4 (9). The structures of these compounds were determined by detailed spectroscopic methods including HR-ESI-MS and 1D and 2D NMR. Compounds 4, 5, 8, 9 were isolated from P. illicioides for the first time. Moreover, it was found that compound 1 showed potent antitumor activity against A549 cells.

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Acknowledgment

This work was supported by Beijing Natural Science Foundation (No. 7142125); National Natural Science Foundation of China (No. 21375147); and the Integrated Drug R&D Platform (No. 2012ZX09301003-001-010) for "the significant creation of new drugs" under major projects of National Science and Technology, China.

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  1. Beijing Institute of Radiation Medicine, No. 27 Taiping Road, Haidian District, 100850, Beijing, P. R. China

    Bing-Kun Xiao, Jian-Yun Yang, Yan-Ru Liu, Jun-Xing Dong & Rong-Qing Huang

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  1. Bing-Kun Xiao
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  2. Jian-Yun Yang
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  3. Yan-Ru Liu
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Correspondence to Rong-Qing Huang.

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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2015, pp. 970–972.

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Xiao, BK., Yang, JY., Liu, YR. et al. Chemical Constituents of Pittosporum illicioides . Chem Nat Compd 51, 1126–1129 (2015). https://doi.org/10.1007/s10600-015-1507-1

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