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Reaction of 3-[(alkylsulfanyl)methyl]pentane-2,4-diones with nicotinic hydrazide

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Chemistry of Heterocyclic Compounds Aims and scope

The reaction of 3-[(alkylsulfanyl)methyl]pentane-2,4-diones with nicotinic hydrazide in ethanol as solvent produces 4-[(alkylsulfanyl)- methyl]-substituted 1-(pyridin-3-yl)carbonyl-1H-pyrazoles, whereas 1-acyl-1H-pyrazoles are formed in acetic, propanoic, or pentanoic acid solution. The reaction in methanol in the presence of ZnCl2 is accompanied by elimination of nicotinic acid and the formation of (alkylsulfanyl)methyl-substituted 1H-pyrazoles.

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The study was carried out on the subject of state assignment (No. AAAA-A19-119011790021-4).

Spectral and analytical results were obtained using the equipment of the Center for Collective Use “Chemistry” of Ufa Institute of Chemistry of the Ufa Federal Research Center of the Russian Academy of Sciences.

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  1. Ufa Institute of Chemistry, Ufa Federal Research Center of the Russian Academy of Sciences, 69 Oktyabrya Ave., Ufa, 450054, Russia

    Larisa A. Baeva, Radik M. Nugumanov, Rail R. Gataullin & Akhnef А. Fatykhov

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  1. Larisa A. Baeva
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  2. Radik M. Nugumanov
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  3. Rail R. Gataullin
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  4. Akhnef А. Fatykhov
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Correspondence to Larisa A. Baeva.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(5), 548–554

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Baeva, L.A., Nugumanov, R.M., Gataullin, R.R. et al. Reaction of 3-[(alkylsulfanyl)methyl]pentane-2,4-diones with nicotinic hydrazide. Chem Heterocycl Comp 56, 548–554 (2020). https://doi.org/10.1007/s10593-020-02698-1

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  • DOI: https://doi.org/10.1007/s10593-020-02698-1

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