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Synthesis of 7-arylimidazo[1,2-a]pyrazin-8(7H)-one derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

A suitable approach to the synthesis of 7-arylimidazo[1,2-a]pyrazin-8(7H)-ones starting from esters of oxalic acid monoamides via cyclization of intermediate 3-aminopyrazin-2-ones with α-halocarbonyl compounds has been suggested.

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Authors and Affiliations

  1. National University of Pharmacy, 53 Pushkinska St., Kharkiv, 61002, Ukraine

    Svitlana S. Kovalenko & Oleksandr G. Drushlyak

  2. V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, 61077, Ukraine

    Sergiy M. Kovalenko

  3. I. M. Sechenov First Moscow State Medical University (Sechenovskiy University), 8 Trubeckaya St., Moscow, 119991, Russia

    Natalya D. Bunyatyan

  4. Scientific Centre for Expert Evaluation of Medicinal Products, 8 Build. 2 Petrovsky Blvd., Moscow, 127051, Russia

    Natalya D. Bunyatyan

  5. Chemical Diversity Research Institute, 2a-1 Rabochaya St., Khimki, Moscow Region, 141400, Russia

    Dmitry V. Kravchenko

  6. ChemDiv, Inc., 6605 Nancy Ridge Drive, San Diego, CA, 92121, USA

    Alexandre V. Ivachtchenko

Authors
  1. Svitlana S. Kovalenko
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  2. Oleksandr G. Drushlyak
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  3. Sergiy M. Kovalenko
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  4. Natalya D. Bunyatyan
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  5. Dmitry V. Kravchenko
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  6. Alexandre V. Ivachtchenko
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Corresponding author

Correspondence to Oleksandr G. Drushlyak.

Additional information

Published in Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(4/5), 386–391

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Kovalenko, S.S., Drushlyak, O.G., Kovalenko, S.M. et al. Synthesis of 7-arylimidazo[1,2-a]pyrazin-8(7H)-one derivatives. Chem Heterocycl Comp 55, 386–391 (2019). https://doi.org/10.1007/s10593-019-02469-7

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  • DOI: https://doi.org/10.1007/s10593-019-02469-7

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