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Synthesis of N-substituted 2-aminomethyl-5-methyl-7-phenyloxazolo[5,4-b]pyridines

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Chemistry of Heterocyclic Compounds Aims and scope

2-(Chloromethyl)-5-methyl-7-phenyloxazolo[5,4-b]pyridine was obtained by intramolecular cyclization based on the previously synthesized 2-chloro-N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)acetamide. The possibility of its use in the synthesis of previously unknown 2-aminomethyloxazolo[5,4-b]pyridine derivatives by nucleophilic substitution with various amines and a cyclic amide has been shown.

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The study was carried out with the financial support of the Russian Foundation for Basic Research within the framework of research project No. 18-33-01143.

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Authors and Affiliations

  1. Institute of Chemistry, University of Tyumen, 15a Perekopskaya St., Tyumen, 625003, Russia

    Irina V. Palamarchuk & Ivan V. Kulakov

  2. F. M. Dostoevsky Omsk State University, 55a Mira Ave., Omsk, 644077, Russia

    Mariya V. Matsukevich & Aleksander S. Fisyuk

  3. Sh. Ualikhanov Kokshetau State University, 76 Abaya St., Kokshetau, Kazakhstan, 020000

    Tulegen М. Seilkhanov

  4. Omsk State Technical University, 11 Mira Ave., Omsk, 644050, Russia

    Aleksander S. Fisyuk

Authors
  1. Irina V. Palamarchuk
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  2. Mariya V. Matsukevich
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  3. Ivan V. Kulakov
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  4. Tulegen М. Seilkhanov
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  5. Aleksander S. Fisyuk
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Corresponding author

Correspondence to Ivan V. Kulakov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(8), 788–791

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Palamarchuk, I.V., Matsukevich, M.V., Kulakov, I.V. et al. Synthesis of N-substituted 2-aminomethyl-5-methyl-7-phenyloxazolo[5,4-b]pyridines. Chem Heterocycl Comp 55, 788–791 (2019). https://doi.org/10.1007/s10593-019-02537-y

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  • DOI: https://doi.org/10.1007/s10593-019-02537-y

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